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https://repository.monashhealth.org/monashhealthjspui/handle/1/32577| Title: | Genetic screening of infertile men. | Authors: | Lynch M.;Salvado C.;McLachlan R.I.;de Krester D.M.;Cram D.;O'Bryan M.K. | Institution: | (Cram, O'Bryan, Salvado, de Krester) Monash Inst. of Reprod./Development, Monash University, 27-31 Wright St., Clayton, Vic., Australia (Cram) Monash IVF, Epworth Hospital, Melbourne, Vic., Australia (Lynch, McLachlan) Prince Henry's Inst. Reprod./Devmt., Department of Obstetrics/Gynaecology, Monash Medical Centre, Melbourne, Vic., Australia | Issue Date: | 18-Oct-2012 | Copyright year: | 2004 | Publisher: | CSIRO (P.O. Box 1139, Collingwood VIC 3066, Australia) | Place of publication: | Australia | Publication information: | Reproduction, Fertility and Development. 16 (5) (pp 573-580), 2004. Date of Publication: 2004. | Abstract: | Male infertility is an extraordinarily common medical condition, affecting 1 in 20 men. According to the World Health Organization, this condition is now considered to be a complex disease involving physical, genetic and environmental factors. With continuing advances in our understanding of male reproductive physiology and endocrinology, together with the availability of the complete sequence of the human genome and powerful functional genomic techniques, the stage is now set to identify the genes that are essential for spermatogenesis. Given that the process of spermatogenesis, from the germ cell to mature sperm, is complex, the challenge for research is to develop the strategies for identifying new genetic causes of idiopathic male infertility and defining genotypes associated with specific defects in semen parameters and testicular pathologies. Such information will form the basis of new genetic tests that will allow the clinician to make an accurate diagnosis of the male partner and a more informed decision about treatment options for the couple. © CSIRO 2004. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1071/RD03097 | PubMed URL: | 15367372 [http://www.ncbi.nlm.nih.gov/pubmed/?term=15367372] | ISSN: | 1031-3613 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/32577 | Type: | Article | Subjects: | *genetic screening genotype germ cell human intracytoplasmic sperm injection male *male infertility/di [Diagnosis] *male infertility/et [Etiology] *male infertility/th [Therapy] medical information outcomes research pathogenesis semen analysis spermatogenesis spermatozoon maturation testis disease treatment planning genomic DNA/ec [Endogenous Compound] membrane protein/ec [Endogenous Compound] messenger RNA/ec [Endogenous Compound] protein Ret/ec [Endogenous Compound] transmembrane conductance regulator/ec [Endogenous Compound] human genome article autosomal recessive inheritance azoospermia/di [Diagnosis] azoospermia/et [Etiology] azoospermia/th [Therapy] chromosome deletion chromosome Yq cystic fibrosis diagnostic accuracy DNA determination environmental factor gene function gene identification gene mutation gene sequence gene technology genetic analysis genetic association gene mutation gene sequence gene technology genetic analysis genetic association *genetic screening genotype germ cell human human genome intracytoplasmic sperm injection male *male infertility / *diagnosis / *etiology / *therapy medical information outcomes research pathogenesis semen analysis spermatogenesis azoospermia / diagnosis / etiology / therapy testis disease treatment planning autosomal recessive inheritance article spermatozoon maturation chromosome deletion chromosome Yq cystic fibrosis diagnostic accuracy DNA determination environmental factor gene function gene identification |
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