Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/35577
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mirzaee S. | en |
dc.contributor.author | Brown A.J. | en |
dc.contributor.author | West N.E.J. | en |
dc.contributor.author | Cameron J.D. | en |
dc.contributor.author | Soon K. | en |
dc.contributor.author | Nogic J. | en |
dc.contributor.author | Thein P. | en |
dc.contributor.author | Comella A. | en |
dc.date.accessioned | 2021-05-14T12:01:30Z | en |
dc.date.available | 2021-05-14T12:01:30Z | en |
dc.date.copyright | 2019 | en |
dc.date.created | 20191120 | en |
dc.date.issued | 2019-11-20 | en |
dc.identifier.citation | Cardiovascular Revascularization Medicine. 20 (10) (pp 865-870), 2019. Date of Publication: October 2019. | en |
dc.identifier.issn | 1553-8389 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/35577 | en |
dc.description.abstract | Background/purpose: Biodegradable-polymer (BP) and polymer-free (PF) drug eluting stents (DES) were developed to reduce the risk of delayed arterial healing observed with durable-polymer (DP) platforms. Although trials demonstrate BP-DES and PF-DES are non-inferior to DP-DES, there is limited data directly comparing these technologies. We performed a meta-analysis to assess the efficacy and safety of BP-DES versus PF-DES for the treatment of coronary artery disease. Methods/materials: Electronic searches were performed identifying randomized trials comparing BP-DES with PF-DES. Co-primary efficacy endpoints were target vessel revascularization (TVR), target lesion revascularization (TLR) and angiographic in-stent late lumen loss (LLL). Co-secondary safety endpoints were all-cause death, myocardial infarction (MI) and stent thrombosis (ST). Result(s): Of 208 studies, 5 met inclusion criteria including 1975 patients. At mean follow-up (14 +/- 5 months), BP-DES were associated with significantly reduced rates of TVR (OR 0.58, 95%CI 0.37-0.92, p = 0.02), TLR (4.7% vs 9.5%) (OR 0.48, 95%CI 0.31-0.75, p = 0.001) and in-stent LLL (pooled mean difference -0.20 mm, 95%CI -0.24 to -0.16, p < 0.001). There was no difference in safety, including all-cause death (OR 1.24, 95%CI 0.68-2.28, p = 0.48), MI (OR 0.92, 95%CI 0.54-1.56, p = 0.75) or ST (OR 1.58, 95%CI 0.67-3.73, p = 0.30). Conclusion(s): These data suggests that BP-DES are more efficacious when compared with PF-DES for the treatment of CAD.Copyright © 2018 Elsevier Inc. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Elsevier Inc. (E-mail: usjcs@elsevier.com) | en |
dc.relation.ispartof | Cardiovascular Revascularization Medicine | en |
dc.title | Biodegradable-Polymer Versus Polymer-Free Drug-Eluting Stents for the Treatment of Coronary Artery Disease. | en |
dc.type | Article | en |
dc.type.studyortrial | Systematic review and/or meta-analysis | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.carrev.2018.12.010 | en |
dc.publisher.place | United States | en |
dc.identifier.pubmedid | 30578169 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30578169] | en |
dc.identifier.source | 2001385940 | en |
dc.identifier.institution | (Nogic, Thein, Mirzaee, Comella, Cameron, Brown) Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Melbourne, Victoria, Australia (Soon) Department of Cardiology, Eastern Health, Melbourne, Victoria, Australia (West) Department of Interventional Cardiology, Royal Papworth Hospital, Cambridge, United Kingdom | en |
dc.description.address | A.J. Brown, Monash Cardiovascular Research Centre and MonashHeart, Monash Health, 246 Clayton Road, Clayton, Melbourne, Victoria, Australia. E-mail: ajdbrown@me.com | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2019 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Biodegradable-polymer stent Coronary artery disease Drug-eluting stent Percutaneous coronary intervention Polymer-free stent | en |
dc.identifier.authoremail | Brown A.J.; ajdbrown@me.com | en |
dc.description.grant | Organization: (MU) *Monash University* Organization No: 501100001779 Country: Australia | en |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Cardiology (MonashHeart & Victorian Heart Institute) | - |
Appears in Collections: | Articles |
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.