Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/38345
Title: | Feasibility of Real-Time Angiographic Perfusion Imaging in the Treatment of Cerebral Vasospasm. | Authors: | Lai L.T. ;Donaldson C.;O'Neill A.H.;Slater L.-A.;Chong W.;Chandra R.V. | Institution: | (Donaldson, Lai) Department of Neurosurgery, Monash Medical Centre, Monash Health, 246 Clayton Road Clayton, Melbourne, VIC 3168, Australia (O'Neill, Slater, Chong, Chandra) Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia (Slater, Chong, Chandra) Diagnostic and Interventional Neuroradiology, Monash Imaging, Monash Health, Australia (Lai) Department of Surgery, School of Clinical Sciences, Monash University, Melbourne, VIC, Australia | Issue Date: | 17-Oct-2017 | Copyright year: | 2017 | Publisher: | S. Karger AG | Place of publication: | Switzerland | Publication information: | Interventional Neurology. 6 (3-4) (pp 163-169), 2017. Date of Publication: 01 Oct 2017. | Journal: | Interventional Neurology | Abstract: | Background: Objective assessment and quantification of the severity of cerebral vasospasm following aneurysmal subarachnoid hemorrhage is not routinely utilized. We investigated the feasibility of angiographic perfusion imaging derived from digital subtraction angiography (DSA) following endovascular vasospasm treatment procedures. Methodology: Real-time blood flow analysis was performed using parametric color coding on pre- and postintervention DSA. Semiquantitative parenchymal perfusion parameters (arrival time [AT] of contrast, time to peak [TTP] opacification, and mean transit time [MTT] of contrast) were calculated across 3 vascular territories (anterior cerebral artery [ACA], middle cerebral artery [MCA], and lenticulostriate arteries) using standard 2-D angiographic perfusion software. The pre- and postintervention arterial vessel diameters were compared. Result(s): Twelve endovascular vasospasm treatments in 6 patients were performed. All patients received intra-arterial vasodilator therapy with either nimodipine, milrinone, or both. Following intra-arterial intervention, parenchymal flow analysis showed improvement in TTP and MTT across all vascular territories (p < 0.002) and improvement in AT in the ACA and MCA territories (p < 0.03). Improvement in parenchymal perfusion parameters was associated with improvement in vessel diameters in all territories following treatment (p < 0.05). Conclusion(s): Real-time parenchymal perfusion imaging during endovascular vasospasm treatment procedures is feasible and provides reliable semiquantitative measurement of angiographic treatment response.Copyright © 2017 S. Karger AG, Basel. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1159/000468157 | Link to associated publication: | Click here for full text options | ISSN: | 1664-9737 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/38345 | Type: | Article | Subjects: | artery diameter article *brain angiography brain artery aneurysm brain blood flow brain perfusion *brain vasospasm/di [Diagnosis] *brain vasospasm/su [Surgery] clinical article comparative study *digital subtraction angiography endovascular surgery *feasibility study female flow measurement human image analysis intervention study middle cerebral artery priority journal quantitative analysis retrospective study *scintigraphy subarachnoid hemorrhage treatment outcome vasodilatation milrinone nimodipine arrival time of contrast mean transit time of contrast time to peak opacification male analytical parameters adult aged aneurysm rupture anterior cerebral artery *digital subtraction angiography endovascular surgery *feasibility study female flow measurement human image analysis intervention study male middle cerebral artery priority journal quantitative analysis retrospective study *scintigraphy subarachnoid hemorrhage treatment outcome vasodilatation brain blood flow brain artery aneurysm *brain angiography Article artery diameter anterior cerebral artery aneurysm rupture adult *brain vasospasm / *diagnosis / *surgery clinical article comparative study analytical parameters aged brain perfusion |
Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.