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https://repository.monashhealth.org/monashhealthjspui/handle/1/38674| Title: | Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth. | Authors: | Saif Z.;Lu N.Z.;Kumar S.;Chong S.;Clifton V.L.;Cuffe J.;Moritz K.M.;Cole T.J.;Fuller P.J. | Institution: | (Clifton, Kumar, Chong, Saif) Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia (Cuffe) School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia (Moritz) School of Biomedical Sciences and Centre for Child Health Research, The University of Queensland, Brisbane, Australia (Cole) Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia (Fuller) Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Monash Medical Centre, Melbourne, Australia (Lu) Division of Allergy-Immunology, Department of Medicine, Northwestern University, Chicago, IL, United States | Issue Date: | 1-Jun-2017 | Copyright year: | 2017 | Publisher: | W.B. Saunders Ltd | Place of publication: | United Kingdom | Publication information: | Placenta. 54 (pp 24-29), 2017. Date of Publication: June 2017. | Journal: | Placenta | Abstract: | The physiological mechanisms that confer different outcomes in morbidity and mortality of the fetus exposed to stressful environments may be driven by significant differences in the expression and function of the placental glucocorticoid receptor (GR). The recent discovery that the placenta contains at least 8 different isoforms of the GR raises questions about the regulation and physiological relevance of the many GR variants expressed in the placenta. The current data also highlights that individual differences in glucocorticoid sensitivity, variations in the effect of different complications of pregnancy on birth outcomes and sex differences in the response to stress, may all be dependent on a specific GR isoform expression profile. This review will investigate the current state of knowledge of GR isoforms in the placenta and discuss the potential role of these multiple isoforms in regulating glucocorticoid sensitivity.Copyright © 2016 Elsevier Ltd | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.placenta.2016.12.017 | ORCID: | Clifton V.L.; ORCID: http://orcid.org/0000-0002-4892-6748 Chong S.; ORCID: http://orcid.org/0000-0001-8062-7281 | PubMed URL: | 28017357 [http://www.ncbi.nlm.nih.gov/pubmed/?term=28017357] | ISSN: | 0143-4004 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/38674 | Type: | Review | Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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