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Title: | Recent trends in early stage response to combination antiretroviral therapy in Australia. | Authors: | Petoumenos K.;McManus H.;Hoy J.F.;Woolley I. ;Boyd M.A.;Kelly M.D.;Mulhall B.;Law M.G.;Roth N.J. | Monash Health Department(s): | Infectious Diseases and Clinical Microbiology | Institution: | (McManus, Boyd, Mulhall, Petoumenos, Law) Kirby Institute, University of New South Wales, Sydney, Australia (Hoy) Alfred Hospital, Melbourne, Australia (Hoy, Woolley) Department of Medicine, Monash University, Melbourne, Australia (Woolley) Department of Infectious Diseases, Monash University, Melbourne, Australia (Woolley) Infectious Diseases, Monash Medical Centre, Melbourne, Australia (Kelly) Brisbane Sexual Health Service, Brisbane, Australia (Mulhall) School of Public Health, University of Sydney, Camperdown, Australia (Roth) Prahran Market Clinic, Prahran, Australia | Issue Date: | 25-Jul-2015 | Copyright year: | 2015 | Publisher: | International Medical Press Ltd (E-mail: imp@intmedpress.com) | Place of publication: | United Kingdom | Publication information: | Antiviral Therapy. 20 (2) (pp 131-139), 2015. Date of Publication: 2015. | Journal: | Antiviral Therapy | Abstract: | Background: There have been improvements in combination antiretroviral therapy (cART) over the past 15 years. The aim of this analysis was to assess whether improvements in ART have resulted in improvements in surrogates of HIV outcome. Method(s): Patients in the Australian HIV Observational Database who initiated treatment using mono/duo therapy prior to 1996, or using cART from 1996 onwards, were included in the analysis. Patients were stratified by era of ART initiation. Median changes in CD4+ T-cell count and the proportion of patients with detectable HIV viral load (>400 copies/ml) were calculated over the first 4 years of treatment. Probabilities of treatment switch were estimated using the Kaplan-Meier method. Result(s): A total of 2,753 patients were included in the analysis: 28% initiated treatment <1996 using mono/duo therapy and 72% initiated treatment >=1996 using cART (30% 1996-1999, 12% 2000-2003, 11% 2004-2007 and 19% >=2008). Overall CD4+ T-cell count response improved by later era of initiation (P<0.001), although 2000-2003 CD4+ T-cell count response was less than that for 1996-1999 (P=0.007). The average proportion with detectable viral load from 2 to 4 years post-treatment commencement by era was: <1996 mono/duo 0.69 (0.67-0.71), 1996-1999 cART 0.29 (0.28-0.30), 2000-2003 cART 0.22 (0.20-0.24), 2004-2007 cART 0.09 (0.07-0.10) and >=2008 cART 0.04 (0.03-0.05). Probability of treatment switch at 4 years after initiation decreased from 53% in 1996-1999 to 29% after 2008 (P<0.001). Conclusion(s): Across the five time-periods examined, there have been incremental improvements for patients initiated on cART, as measured by overall response (viral load and CD4+ T-cell count) and also increased durability of first-line ART regimens.Copyright ©2015 International Medical Press. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.3851/IMP2774 | ISSN: | 1359-6535 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/41139 | Type: | Article | Subjects: | virus load *antiretrovirus agent/dt [Drug Therapy] longitudinal study adult aged article Australia CD4 lymphocyte count female human Human immunodeficiency virus *Human immunodeficiency virus infection/dt [Drug Therapy] Human immunodeficiency virus infection/dt [Drug Therapy] Kaplan Meier method major clinical study male monotherapy observational study priority journal probability therapy treatment duration treatment outcome *treatment response longitudinal study major clinical study male monotherapy observational study priority journal probability therapy treatment duration treatment outcome Australia virus load Article adult aged *treatment response CD4 lymphocyte count female human Human immunodeficiency virus *Human immunodeficiency virus infection / *drug therapy Human immunodeficiency virus infection / drug therapy Kaplan Meier method |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
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