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Title: Social Activities and Risk of Dementia in Community-Dwelling Older People: Gender-Specific Findings From a Prospective Cohort Study.
Authors: Htun H.L.;Teshale A.B.;Owen A.J.;Ryan J. ;Woods R.L.;Orchard S.G.;Hajek A.;Lysen T.;Shah R.C.;Chong T.T.-J.;Sheets K.M.;Joyce J.;Murray A.M.;Freak-Poli R.
Monash Health Department(s): Monash University - School of Clinical Sciences at Monash Health
Institution: (Htun, Teshale, Owen, Ryan, Woods, Orchard, Freak-Poli) School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia
(Hajek) Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
(Lysen) Independent Researcher, Utrecht, Netherlands
(Shah) Department of Family and Preventive Medicine and the Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States
(Chong) Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia
(Sheets) Department of Medicine, University of Minnesota, Minneapolis, MN, United States
(Sheets, Murray) Division of Geriatric Medicine, Department of Medicine, Hennepin Healthcare, Minneapolis, MN, United States
(Joyce) Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia
(Murray) Berman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Minneapolis, MN, United States
(Freak-Poli) School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia
Issue Date: 24-Apr-2024
Copyright year: 2024
Place of publication: United States
Publication information: The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences. 79(5) (no pagination), 2024. Date of Publication: 01 May 2024.
Journal: The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Abstract: OBJECTIVES: This study examines the gender-specific associations between a wide range of social activities and dementia risk. METHOD(S): A prospective cohort study was conducted involving community-dwelling older Australians (>=70 years) without significant cognitive impairment at enrolment. During the first year of enrolment, we assessed 25 self-reported social activities covering various aspects, including support from relatives and friends, community participation, social interactions with surroundings, and loneliness. Dementia diagnosis followed DSM-IV criteria, adjudicated by an international expert panel. To estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between social activities and dementia, we performed Cox proportional hazards models, adjusting for age, educational attainment, baseline global cognition, and depressive symptoms. RESULT(S): Among 9,936 participants who completed all social activity questionnaires (median [IQR] age: 73.4 [71.6-77.1] years; 47.4% men), dementia was diagnosed in 3.8% of men (n = 181/4,705) and 2.6% of women (n = 138/5,231) over a median 6.4 years (IQR: 5.3-7.6, range: 0.2-10.1) follow-up. Gender-specific relationships emerged: caregiving for a person with illness/disability in women (HR: 0.65, 95% CI: 0.42-0.99), and having >=9 relatives feeling close to call for help in men (HR: 0.56, 95% CI: 0.33-0.96; reference <9 relatives) were associated with reduced dementia risk. Unexpectedly, in women, having >=5 friends with whom they felt comfortable discussing private matters were associated with a greater dementia risk (HR: 1.69, 95% CI: 1.10-2.59; reference <=2 friends). Imputed models further identified that babysitting/childminding was associated with lower dementia risk in men (HR: 0.75, 95% CI: 0.56-0.99). No other social activities showed significant associations with dementia. DISCUSSION: This study provides evidence of social activities influencing dementia risk. Further investigations are required to uncover the mechanisms driving these observed relationships.Copyright © The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America.
PubMed URL: 38567686 []
Type: Article
Subjects: cognitive defect
Type of Clinical Study or Trial: Observational study (cohort, case-control, cross sectional, or survey)
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