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https://repository.monashhealth.org/monashhealthjspui/handle/1/53360| Title: | Association between congenital anomalies and late-onset bacterial infections in neonates admitted to neonatal intensive care units in Australia and New Zealand: a population-based cohort study. | Authors: | Chughtai A.A.;Parmar T.;Schindler T.;Chow S.S.W.;Morris S.;Schmidt P.;Chauhan M.;Korostenski L.;Sharp M.;Resnick S.;Thomas R.;Strunk T.;Stack J.;Birch P.;Oliver T.;Casalaz D.;Holberton J.;Stewart A. ;Hunt R.;Tan K. ;Cooke L.;Downe L.;Davis J.;Stewart M.;Berry A.;Hickey L.;Kgosiemang M.;Paoli T.D.;Spotswood N.;Bolisetty S.;Lui K.;Staub E.;Greenhalgh M.;Koorts P.;Jacobs S.;Keir A.;Collins C.;Numa A.;Carlisle H.;Badawi N.;Popat H.;Alcock G.;Luig M.;Kent A.;Dixon B.;Darlow B.;Fowlie P.;Kelly A.;Bloomfield G.;Buksh M.;Battin M.;Boom J.V.D.;Miller H.;Allermo-Fletcher A.;Jacobs C.;Rajadurai V.S.;Lam S.;Chambers G.;Barker D.;Dhawan A.;Merida N.;Harrison D. | Institution: | (Chughtai) School of Population Health, University of New South Wales, Sydney, NSW, Australia (Spotswood) Women's and Children's Services, Royal Hobart Hospital, Hobart, TAS, Australia (Spotswood) Burnet Institute, University of Melbourne, Melbourne, VIC, Australia (Strunk) Child and Adolescent Health Service, King Edward Memorial Hospital, Perth, WA, Australia (Strunk) Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia (Parmar, Schindler) Royal Hospital for Women, University of New South Wales, Sydney, NSW, Australia (Popat) Grace Centre for Newborn Intensive Care, The Children's Hospital at Westmead, Nhmrc Clinical Trial Centre, The University of Sydney, Sydney, NSW, Australia (Chow) Centre for Big Data Research in Health, University of New South Wales, Sydney, NSW, Australia (Lui) School of Clinical Medicine, Discipline of Paediatrics and Child Health, University of New South Wales, Royal Hospital for Women, Sydney, NSW, Australia (Morris) Flinders Medical Centre, SA, Australia (Schmidt, Kgosiemang) Gold Coast University Hospital, QLD, Australia (Stack, Birch, Davis, Paoli) John Hunter Children's Hospital, NSW, Australia (Spotswood) King Edward Memorial and Perth Children's Hospitals, WA, Australia (Bolisetty) Liverpool Hospital, NSW, Australia (Lui) Mater Mother's Hospital, QLD, Australia (Staub) Mercy Hospital for Women, VIC, Australia (Downe, Greenhalgh) Monash Medical Centre, VIC, Australia (Oliver, Koorts) Neonatal Retrieval Emergency Service Southern Queensland, QLD, Australia (Casalaz, Jacobs) Nepean Hospital, NSW, Australia (Keir) Newborn Emergency Transport Service, WA, Australia (Resnick, Strunk, Collins) Paediatric Infant Perinatal Emergency Retrieval, VIC, Australia (Sharp, Numa) Newborn and Paediatric Emergency Transport Service, NSW, Australia (Korostenski, Carlisle) Royal Children's Hospital, VIC, Australia (Holberton, Badawi) Royal Darwin Hospital, NT, Australia (Hickey, Popat) Royal Hobart Hospital, TAS, Australia (Alcock) Royal Hospital for Women, NSW, Australia (Luig) Royal North Shore Hospital, NSW, Australia (Kent) Royal Prince Alfred Hospital, NSW, Australia (Dixon) Royal Brisbane and Women's Hospital, QLD, Australia (Cooke, Darlow) Royal Women's Hospital, VIC, Australia (Stewart, Fowlie) Saas MedSTAR Kids, SA, Australia (Tan) Sunshine Hospital, VIC, Australia (Thomas, Berry) Sydney Children's Hospital, NSW, Australia (Chauhan) The Canberra Hospital, ACT, Australia (Fowlie) The Children's Hospital at Westmead, NSW, Australia (Kelly) Townsville University Hospital, QLD, Australia (Buksh) Westmead Hospital, NSW, Australia (Bloomfield, Battin) Women's and Children's Hospital, SA, Australia (Boom) Christchurch Women's Hospital, Germany (Miller) Christchurch School of Medicine, Germany (Allermo-Fletcher) Dunedin Hospital, New Zealand (Jacobs) Middlemore Hospital, New Zealand (Rajadurai) Auckland City Hospital, New Zealand (Hunt, Rajadurai) Waikato Hospital, New Zealand (Stewart, Lam) Wellington Women's Hospital;, United Kingdom (Chambers) Kk Women's and Children's Hospital, Singapore, Singapore (Barker) Prince of Wales Hospital, Hong Kong (Dhawan) National Perinatal Epidemiology and Statistics Unit, University of New South Wales, Australia (Merida) Whangarei Hospital, New Zealand (Harrison) Blacktown Hospital, NSW, Australia |
Issue Date: | 5-Mar-2025 | Copyright year: | 2025 | Publisher: | S. Karger AG | Place of publication: | Switzerland | Publication information: | Neonatology. 122(1) (pp 95-105), 2025. Date of Publication: 01 Feb 2025. | Journal: | Neonatology | Abstract: | Introduction: Compromised neonatal intensive care unit neonates are at risk of acquiring late-onset infections (lateonset sepsis [LOS]). Neonates born with congenital anomalies (CAs) could have an additional LOS risk. Method(s): Utilising the population-based Australian and New Zealand Neonatal Network data from 2007 to 2017, bacterial LOS rates were determined in very preterm (VPT, <32 week), moderately preterm (MPT, 32-36 weeks), and term (FT, 37-41 weeks) neonates with or without CA. Stratified by major surgery, the association between CA and bacterial LOS was evaluated. Result(s): Of 102,808 neonates, 37.7%, 32.8%, and 29.6% were born VPT, MPT, and FT, respectively. Among these, 3.4% VPT, 7.5% MPT, and 16.2% FT neonates had CA. VPT neonates had the highest LOS rate (11.1%), compared to MPT (1.8%) and FT (1.8%) neonates. LOS rates were higher in CA neonates than those without (8.2% versus 5.1% adjusted relative risk [aRR] 1.67, 95% confidence interval [CI]: 1.45-1.92). Neonates with surgery had a higher LOS rate (14.2%) than neonates without surgery (4.4%, p < 0.001). Among the neonates without surgery, CA neonates had consistently higher LOS rates than those without CA (VPT 14.3% vs. 9.6% [aRR 1.32, 95% CI: 1.11-1.57]; MPT 4% vs. 0.9% [aRR 4.45, 95% CI: 3.23-6.14]; and FT 2% vs. 0.7% [aRR 2.87, 95% CI: 1.97-4.18]). For the neonates with surgery, CAs were not associated with additional LOS risks. Conclusion(s): Overall we reported higher rates of LOS in neonates with CA compared to those without CA. Regardless of gestation, CA was associated with an increased LOS risk among nonsurgical neonates. Optimisation of infection prevention strategies for CA neonates should be explored. Future studies are needed to evaluate if the infection risk is caused by CA or associated complications.Copyright © 2025 S. Karger AG. All rights reserved. | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1159/000540276 | PubMed URL: | 39299217 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/53360 | Type: | Article | Subjects: | bacterial infection congenital malformation neonatal intensive care unit newborn |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional, or survey) |
| Appears in Collections: | Articles |
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