Identification of aldosterone-producing adenomas using [68Ga]Ga-PentixaFor PET/CT

Abstract

Differentiation between bilateral and unilateral (aldosterone-producing adenoma, APA) causes of primary aldosteronism (PA) relies on CT imaging of the adrenal glands and adrenal vein sampling (AVS), the latter of which is the current gold standard. CT imaging is limited by a high rate of adrenal incidentalomas, which can lead to dilemmas in management and pursuance of extensive investigations. AVS is operator dependent, labour intensive, expensive and invasive, also posing the risk of a failed or inconclusive study. We conduct this pilot prospective study in adults with confirmed PA with the objective of evaluating the efficacy of 68Ga-PentixaFor PET-CT in determining if an adrenal adenoma is the cause for primary aldosteronism, compared to AVS as the gold standard.