Study on How Nerve Signalling is Affected by a High-Fibre Supplement in Untreated Hypertensive Individuals.

Abstract

We propose a novel hypothesis that short-chain fatty acids (SCFAs) influence BP through the ‘gut-brain axis’. The two key systems involved in this process are the 'fight or flight' (sympathetic nervous system, SNS) and the 'rest and digest' (parasympathetic nervous system, PNS), both part of the autonomic nervous system (ANS). Our primary aim is to quantify if SCFAs modulate SNS and PNS activity associated with BP regulation. Understanding the influence of SCFAs on the gut-brain axis could pave the way for new treatments for hypertension and other conditions linked to this axis, such as irritable bowel syndrome and neuropsychiatric disorders like depression and anxiety. This research could lead to advances in managing these debilitating conditions.