Reversible corona radiata diffusion restriction in hypoglycemic coma

Abstract

Thirty-four hours after last being seen well, a 45-year-old diabetic woman was discovered in profound hypoglycemic coma. Magnetic resonance imaging (MRI) revealed bilateral symmetrical corona radiata signal abnormality with diffusion restriction (Figure 1A-C). Electroencephalogram revealed diffuse slowing. Overall, a poor clinical outcome was predicted. However, with rapid establishment of euglycemia and supportive care, the patient slowly recovered over the next 4 weeks. Repeat MRI showed reversal of all neuroimaging findings (Figure 1D-F). By 3 months, she was discharged home with a modified Rankin scale score of 1.