Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/26602
Title: | Total body catecholamine kinetics before and after birth in spontaneously hypoxemic fetal lambs. | Authors: | Esler M.D.;Smolich J.J. | Institution: | (Smolich) Centre for Heart and Chest Research, Department of Medicine, Monash University, Clayton, Vic. 3168, Australia (Smolich) Inst. of Repro. and Development, Monash University, Clayton, Vic. 3168, Australia (Esler) Baker Medical Research Institute, Prahran, Vic. 3181, Australia (Smolich) Cardiology Unit, Monash Medical Centre, 246 Clayton Rd., Clayton, Vic. 3168, Australia | Issue Date: | 20-Oct-2012 | Copyright year: | 1999 | Publisher: | American Physiological Society American Physiological Society (9650 Rockville Pike, Bethesda MD 20814-3991, United States) |
Place of publication: | United States | Publication information: | American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 277 (5 46-5) (pp R1313-R1320), 1999. Date of Publication: November 1999. | Journal: | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | Abstract: | To study the effect of fetal hypoxemia on perinatal norepinephrine and epinephrine total body kinetics, 13 near-term fetal lambs were instrumented with vascular catheters under general anesthesia. One week later, norepinephrine and epinephrine kinetics were measured in normoxemic (n = 7) or spontaneously hypoxemic fetuses (n = 6) with isotope dilution methodology. Hypoxemic fetuses had lower body (P < 0.02) and placental (P = 0.01) weights and a threefold elevation in plasma norepinephrine (P < 0.005) and epinephrine (P < 0.025) associated with correspondingly higher total body norepinephrine (P < 0.005) and epinephrine (P < 0.05) spillovers. After birth, total body norepinephrine and epinephrine spillover increased 45% and 3.2-fold, respectively, in normoxemic animals (both P < 0.001). However, in the hypoxemic group, norepinephrine total body spillover was unchanged between fetal and 1-h lambs and then fell in 4-h lambs (P < 0.005). In addition, total body epinephrine release rose postnatally (P < 0.05) but less than in the normoxemic group (P < 0.02). No differences in norepinephrine or epinephrine total body clearance occurred between normoxemic and hypoxemic groups in either fetal or newborn lambs. These findings indicate that in hypoxemic and growth-restricted fetuses 1) elevated circulating norepinephrine and epinephrine levels are related to increased sympathoadrenal activity and 2) birth is associated with an initial maintenance and subsequent decline in global sympathetic activity but a blunting of adrenal medullary activation. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1152/ajpregu.1999.277.5.r1313 | PubMed URL: | 10564202 [http://www.ncbi.nlm.nih.gov/pubmed/?term=10564202] | ISSN: | 0363-6119 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/26602 | Type: | Article |
Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.