Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/26714| Title: | Genome-wide association study identifies novel breast cancer susceptibility loci. | Authors: | Cox A.;Farshid G.;Fawcett S.;Field M.;Firgaira F.;Fleming J.;Forbes J.;Friedlander M.;Gaff C.;Gardner M.;Gattas M.;George P.;Gill G.;Goldblatt J.;Greening S.;Haan E.;Hart S.;Humphrey E.;Jenkins M.;Kefford R.;Kirk J.;Kollias J.;Kovalenko S.;Lakhani S.;Leary J.;Lim J.;Lindeman G.;Lipton L.;Lobb L.;Maclurcan M.;Marsh D.;McKay M.;Anne McLachlan S.;Mitchell G.;Newman B.;O'Loughlin I.;Osborne R.;Peters L.;Price M.;Reeve J.;Reeve T.;Richards R.;Rinehart G.;Robinson B.;Rudzki B.;Salisbury E.;Saunders C.;Scott E.;Seshadri R.;Shelling A.;Suthers G.;Taylor D.;Tennant C.;Townshend S.;Tyler J.;Venter D.;Visvader J.;Walpole I.;Ward R.;Warner B.;Warren G.;Watson E.;Williams R.;Winship I.;Bowtell D.;Green A.;DeFazio A.;Gertig D.;Webb P.;Milne R.;Young M.A.;Harris M. ;Wilson J. ;Easton D.F.;Pooley K.A.;Dunning A.M.;Pharoah P.D.P.;Thompson D.;Ballinger D.G.;Struewing J.P.;Morrison J.;Field H.;Luben R.;Wareham N.;Ahmed S.;Healey C.S.;Bowman R.;Meyer K.B.;Haiman C.A.;Kolonel L.K.;Henderson B.E.;Le Marchand L.;Brennan P.;Sangrajrang S.;Gaborieau V.;Odefrey F.;Shen C.-Y.;Wu P.-E.;Wang H.-C.;Eccles D.;Evans D.G.;Peto J.;Fletcher O.;Johnson N.;Seal S.;Stratton M.R.;Rahman N.;Chenevix-Trench G.;Bojesen S.E.;Nordestgaard B.G.;Axelsson C.K.;Garcia-Closas M.;Brinton L.;Chanock S.;Lissowska J.;Peplonska B.;Nevanlinna H.;Fagerholm R.;Eerola H.;Kang D.;Yoo K.-Y.;Noh D.-Y.;Ahn S.-H.;Hunter D.J.;Hankinson S.E.;Cox D.G.;Hall P.;Wedren S.;Liu J.;Low Y.-L.;Bogdanova N.;Schurmann P.;Dork T.;Tollenaar R.A.E.M.;Jacobi C.E.;Devilee P.;Klijn J.G.M.;Sigurdson A.J.;Doody M.M.;Alexander B.H.;Zhang J.;Brock I.W.;MacPherson G.;Reed M.W.R.;Couch F.J.;Goode E.L.;Olson J.E.;Meijers-Heijboer H.;Van Den Ouweland A.;Uitterlinden A.;Rivadeneira F.;Milne R.L.;Ribas G.;Gonzalez-Neira A.;Benitez J.;Hopper J.;McCredie M.;Southey M.;Giles G.;Schroen C.;Justenhoven C.;Brauch H.;Hamann U.;Ko Y.-D.;Spurdle A.B.;Beesley J.;Chen X.;Mannermaa A.;Kosma V.-M.;Kataja V.;Hartikainen J.;Day N.E.;Cox D.R.;Ponder B.A.J.;Luccarini C.;Conroy D.;Shah M.;Munday H.;Jordan C.;Perkins B.;West J.;Redman K.;Driver K.;Aghmesheh M.;Amor D.;Andrews L.;Antill Y.;Armes J.;Armitage S.;Arnold L.;Balleine R.;Begley G.;Beilby J.;Bennett I.;Bennett B.;Berry G.;Blackburn A.;Brennan M.;Brown M.;Buckley M.;Burke J.;Butow P.;Byron K.;Callen D.;Campbell I.;Clarke C.;Colley A.;Cotton D.;Cui J.;Culling B.;Cummings M.;Dawson S.-J.;Dixon J.;Dobrovic A.;Dudding T.;Edkins T.;Eisenbruch M. | Institution: | (Easton, Thompson) CR-UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
(Pooley, Dunning, Pharoah, Morrison, Field, Ahmed, Healey, Ponder, Luccarini, Conroy, Shah, Munday, Jordan, Perkins, West, Redman, Driver) Department of Oncology, University of Cambridge, Cambridge CB1 8RN, United Kingdom
(Ballinger, Cox) Perlegen Sciences, Inc., 2021 Stierlin Court, Mountain View, CA 94043, United States
(Struewing, Zhang) Laboratory of Population Genetics, US National Cancer Institute, Bethesda, MD 20892, United States
(Luben, Wareham, Day) EPIC, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom
(Bowman) MRC Dunn Clinical Nutrition Centre, Cambridge CB2 0XY, United Kingdom
(Meyer, Ponder) Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, United Kingdom
(Haiman, Henderson) Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States
(Kolonel, Le Marchand) Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, United States
(Brennan, Gaborieau, Odefrey) International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon 69008, France
(Sangrajrang) National Cancer Institute, Bangkok 10400, Thailand
(Shen, Wu, Wang) Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan (Republic of China)
(Eccles) Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton SO16 5YA, United Kingdom
(Evans) Regional Genetic Service, St. Mary's Hospital, Manchester M13 0JH, United Kingdom
(Peto) London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
(Fletcher, Johnson) Breakthrough Breast Cancer Research Centre, London SW3 6JB, United Kingdom
(Seal, Stratton, Rahman) Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
(Stratton) Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
(Chenevix-Trench, Spurdle, Beesley, Chen, Bowtell, Green, DeFazio, Gertig, Webb) Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia
(Bojesen, Nordestgaard) Department of Clinical Biochemistry, Herlev and Bispebjerg University Hospitals, University of Copenhagen, DK-2730 Herlev, Denmark
(Axelsson) Department of Breast Surgery, Herlev and Bispebjerg University Hospitals, University of Copenhagen, DK-2730 Herlev, Denmark
(Garcia-Closas, Brinton) Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, United States
(Chanock) Advanced Technology Center, National Cancer Institute, Gaithersburg, MD 20877, United States
(Lissowska) Cancer Center, M. Sklodowska-Curie Institute of Oncology, Warsaw 02781, Poland
(Peplonska) Nofer Institute of Occupational Medicine, Lodz 90950, Poland
(Nevanlinna, Fagerholm, Eerola) Departments of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki 00029, Finland
(Eerola) Department of Oncology, Helsinki University Central Hospital, Helsinki 00029, Finland
(Kang, Yoo, Noh) Seoul National University, College of Medicine, Seoul 151-742, South Korea
(Yoo) National Cancer Center, Goyang 411-769, South Korea
(Ahn) Ulsan University, College of Medicine, Ulsan 680-749, South Korea
(Hunter, Cox) Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Ave., Boston, MA 02115, United States
(Hunter, Hankinson) Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Ave., Boston, MA 02115, United States
(Hall, Wedren) Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-171 77, Sweden
(Liu, Low) Population Genetics, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore
(Bogdanova) Department of Radiation Oncology, Hannover Medical School, D-30625 Hannover, Germany
(Bogdanova, Schurmann, Dork) Department of Gynecology and Obstetrics, Hannover Medical School, D-30625 Hannover, Germany
(Tollenaar) Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, Netherlands
(Jacobi) Department of Medical Decision Making, Leiden University Medical Center, 2333 ZA Leiden, Netherlands
(Devilee) Departments of Human Genetics and Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands
(Klijn) Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel Den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, Netherlands
(Sigurdson, Doody) Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, United States
(Alexander) Environmental Health Sciences, University of Minnesota, Minneapolis, MN 55455, United States
(Cox, Brock, MacPherson) Institute for Cancer Studies, Sheffield University Medical School, Sheffield S10 2RX, United Kingdom
(Reed) Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield S10 2RX, United Kingdom
(Couch, Goode, Olson) Mayo Clinic, College of Medicine, Rochester, MN 55905, United States
(Meijers-Heijboer) VU University Medical Center, 1007 MB Amsterdam, Netherlands
(Meijers-Heijboer, Van Den Ouweland) Department of Clinical Genetics, Erasmus University, Rotterdam NL-3015-GE, Netherlands
(Uitterlinden, Rivadeneira) Department of Internal Medicine, Erasmus University, Rotterdam NL-3015-GE, Netherlands
(Milne, Ribas, Gonzalez-Neira, Benitez) Spanish National Cancer Centre (CNIO), Madrid E-28029, Spain
(Hopper, Southey) Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Carlton, Vic. 3053, Australia
(McCredie) Department of Preventive and Social Medicine, University of Otago, Dunedin 9001, New Zealand
(Giles) Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Vic. 3053, Australia
(Schroen) Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Vic. 3052, Australia
(Justenhoven, Brauch) Dr. Margarete Fischer-Bosch-Institute of Clinical Pharamcology, 70376 Stuttgart, Germany
(Hamann) Deutsches Krebsforschungszentrum, Heidelberg 69120, Germany
(Ko) Evangelische Kliniken Bonn gGmbH Johanniter Krankenhaus, 53113 Bonn, Germany
(Chenevix-Trench, Milne, Hopper, McCredie, Southey, Giles, Aghmesheh, Amor, Andrews, Antill, Armes, Armitage, Arnold, Balleine, Begley, Beilby, Bennett, Bennett, Berry, Blackburn, Brennan, Brown, Buckley, Burke, Butow, Byron, Callen, Campbell, Clarke, Colley, Cotton, Cui, Culling, Cummings, Dawson, Dixon, Dobrovic, Dudding, Edkins, Eisenbruch, Farshid, Fawcett, Field, Firgaira, Fleming, Forbes, Friedlander, Gaff, Gardner, Gattas, George, Gill, Goldblatt, Greening, Grist, Haan, Harris, Hart, Hayward, Humphrey, Jenkins, Jones, Kefford, Kirk, Kollias, Kovalenko, Lakhani, Leary, Lim, Lindeman, Lipton, Lobb, Maclurcan, Mann, Marsh, McKay, Anne McLachlan, Meiser, Mitchell, Newman, O'Loughlin, Osborne, Peters, Phillips, Price, Reeve, Reeve, Richards, Rinehart, Robinson, Rudzki, Salisbury, Sambrook, Saunders, Scott, Scott, Scott, Seshadri, Shelling, Spurdle, Suthers, Taylor, Tennant, Thorne, Townshend, Tucker, Tyler, Venter, Visvader, Walpole, Ward, Waring, Warner, Warren, Watson, Williams, Wilson, Winship, Young, Bowtell, Green, DeFazio, Gertig, Webb) Peter MacCallum Cancer Centre, Melbourne, Vic. 3002, Australia
(Mannermaa, Kosma, Kataja, Hartikainen) Insitute of Clinical Medicine, Pathology and Forensic Medicine, University of Kuopio, Kuopio FIN-70210, Finland
(Mannermaa, Kosma, Hartikainen) Departments of Oncology and Pathology, University Hospital of Kuopio, Kuopio FIN-70211, Finland
(Kataja) Department of Oncology, Vaasa Central Hospital, Vaasa 65130, Finland
(Aghmesheh) Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW 2031, Australia
(Amor) Genetic Health Services Victoria, Royal Children's Hospital, Melbourne, Vic. 3050, Australia
(Andrews, Bennett, Meiser, Tucker, Tyler) Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, NSW 2031, Australia
(Antill, Dawson, Phillips, Scott) Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Vic. 3002, Australia
(Armes) Anatomical Pathology, Royal Women's Hospital, Carlton, Vic. 3053, Australia
(Armitage, Arnold, Jones) Molecular Genetics Laboratory, Royal Brisbane and Women's Hospital, Herston, QLD 4029, Australia
(Balleine) Departments of Translational and Medical Oncology, Westmead Hospital, Westmead, NSW 2145, Australia
(Begley) Cancer Biology Laboratory, TVW Institute for Child Health Research, Subiaco, WA 6008, Australia
(Beilby) Pathology Centre, Queen Elizabeth Medical Centre, Nedlands, WA 6009, Australia
(Bennett) Silverton Place, 101 Wickham Terrace, Brisbane, QLD 4000, Australia
(Berry) Department of Public Health and Community Medicine, University of Sydney, Sydney, NSW 2006, Australia
(Blackburn) John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
(Brennan) NSW Breast Cancer Institute, PO Box 143, Westmead, NSW 2145, Australia
(Brown) Department of Biochemistry, University of Queensland, St. Lucia, QLD 4072, Australia
(Buckley) Molecular and Cytogenetics Unit, Prince of Wales Hospital, Randwick, NSW 2031, Australia
(Burke, Humphrey) Royal Hobart Hospital, GPO Box 1061L, Hobart, Tasmania 7001, Australia
(Butow) Medical Psychology Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2204, Australia
(Byron) Australian Genome Research Facility, Walter and Eliza Hall Medical Research Institute, Royal Melbourne Hospital, Parkville, Vic. 3050, Australia
(Callen) Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide/Hanson Institute, Rundle Mall, PO Box 14, SA 5000, Australia
(Campbell, Thorne) Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Vic. 3002, Australia
(Chenevix-Trench, Hayward, Spurdle, Green, Webb) Queensland Institute of Medical Research, Herston, QLD 4006, Australia
(Clarke, Mann) Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia
(Colley) Department of Clinical Genetics, Liverpool Health Service, PO Box 103, Liverpool, NSW 2170, Australia
(Cotton) Mutation Research Centre, St. Vincent's Hospital, Victoria Parade, Fitzroy, Vic. 3065, Australia
(Milne, Southey, Cui) Centre for Genetic Epidemiology, University of Melbourne, 723 Swanston Street, Carlton, Vic. 3053, Australia
(Culling) Molecular and Clinical Genetics, Building 65, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
(Cummings) Department of Pathology, University of Queensland Medical School, Herston, NSW 4006, Australia
(Dixon) Central Regional Genetic Services, Wellington Hospital, Private bag 7902, Wellington South 6039, New Zealand
(Dobrovic, Waring) Molecular Department of Pathology, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, Vic. 3002, Australia
(Dudding, Scott) Hunter Genetics, Hunter Area Health Service, Waratah, NSW 2310, Australia
(Edkins) Clinical Chemistry, Princess Margret Hospital for Children, Box D184, Perth, WA 6001, Australia
(Eisenbruch) Department of Multicultural Health, University of Sydney, NSW 2052, Australia
(Farshid) Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
(Fawcett) Family Cancer Clinic, Monash Medical Centre, Clayton, Vic. 3168, Australia
(Field) Faculty of Medicine, Royal North Shore Hospital, Vindin House, St Leonards, NSW 2065, Australia
(Firgaira, Grist, Seshadri) Department of Haematology, Flinders Medical Centre, Bedford Park, SA 5042, Australia
(Fleming) Eskitis Institute of Cell and Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University, Nathan, QLD 4111, Australia
(Forbes) Surgical Oncology, University of Newcastle, Newcastle Mater Hospital, Waratah, NSW 2298, Australia
(Friedlander) Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW 2031, Australia
(Gaff, Gardner) Victorian Clinical Genetics Service, Royal Melbourne Hospital, Parkville, Vic. 3052, Australia
(Gattas) Queensland Clinical Genetic Service, Royal Children's Hospital, Bramston Terrace, Herston, QLD 4020, Australia
(George) Clinical Biochemistry Unit, Canterbury Health Labs., PO Box 151, Christchurch 8140, New Zealand
(Gill) Department of Surgery, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
(Goldblatt, Townshend, Walpole) Genetic Services of WA, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, WA 6008, Australia
(Greening) Wollongong Hereditary Cancer Clinic, Wollongong Public Hospital, Private Mail Bag 8808, South Coast Mail Centre, NSW 2521, Australia
(Haan, Suthers) Department of Medical Genetics, Women's and Children's Hospital, North Adelaide, SA 5006, Australia
(Harris, McKay, Mitchell, Young) Familial Cancer Clinic, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Vic. 3002, Australia
(Hart) Breast and Ovarian Cancer Genetics, Monash Medical Centre, 871 Centre Road, Bentleigh East, Vic. 3165, Australia
(Hopper, Osborne, Gertig) Centre for Molecular Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Vic. 3010, Australia
(Jenkins) School of Population Health, University of Melbourne, 723 Swanston Street, Carlton, Vic. 3053, Australia
(Kefford) Medical Oncology, Westmead Hospital, Westmead, NSW 2145, Australia
(Kirk, Leary) Familial Cancer Service, Department of Medicine, Westmead Hospital, Westmead, NSW 2145, Australia
(Kollias) Breast Endocrine and Surgical Unit, Royal Adelaide Hospital, North Terrace, SA 5000, Australia
(Kovalenko) Molecular Pathology Department, Southern Cross Pathology, Monash Medical Centre, Clayton, Vic. 3168, Australia
(Lakhani) Molecular and Cellular Pathology, University of Queensland, Herston, QLD 4006, Australia
(Lim, Tennant) Department of Psychological Medicine, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
(Lindeman) Breast Cancer Laboratory, Walter and Eliza Hall Institute, PO Royal Melbourne Hospital, Parkville, Vic. 3050, Australia
(Lipton) Medical Oncology and Clinical Haematology Unit, Western Hospital, Footscray, Vic. 3011, Australia
(Lobb) WA Centre for Cancer, Edith Cowan University, Churchlands, WA 6018, Australia
(Maclurcan, Price) Department of Psychological Medicine, University of Sydney, NSW 2006, Australia
(Marsh) Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
(McCredie) Cancer Epidemiology Research Unit, NSW Cancer Council, 153 Dowling Street, Woolloomooloo, NSW 2011, Australia
(Anne McLachlan) Department of Oncology, St. Vincent's Hospital, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia
(Newman) School of Public Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
(O'Loughlin, Warren, Watson) St. Vincent's Breast Clinic, PO Box 4751, Toowoomba, QLD 4350, Australia
(Peters) Radiation Oncology, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, Vic. 3002, Australia
(Reeve, Winship) Genetic Services, Auckland Hospital, Private Bag 92024, Auckland 1142, New Zealand
(Reeve) Cancer Genetics Laboratory, University of Otago, PO Box 56, Dunedin 9054, New Zealand
(Richards) Department of Cytogenetics and Molecular Genetics, Women and Children's Hospital, Adelaide, SA 5006, Australia
(Rinehart) Hancock Family Breast Cancer Foundation, PO Locked Bag 2, West Perth, WA 6005, Australia
(Robinson) Oncology Service, Christchurch Hospital, Private Bag 4710, Christchurch 8140, New Zealand
(Rudzki) Molecular Pathology Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia
(Salisbury) Section of Cytology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW 2145, Australia
(Saunders) School of Surgery and Pathology, QE11 Medical Centre, M block, Nedlands, WA 6907, Australia
(Scott) South View Clinic, South Street, Kogarah, NSW 2217, Australia
(Shelling) Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
(Taylor) Department of Radiology, Royal Perth Hospital, Box X2213, Perth, WA 6011, Australia
(Venter) Murdoch Institute, Royal Children's Hospital, Parkville, Vic. 3050, Australia
(Visvader) Molecular Genetics of Cancer Division, Walter and Eliza Hall Medical Research Institute, Royal Melbourne Hospital, Parkville, Vic. 3050, Australia
(Ward) Department of Medical Oncology, St. Vincents Hospital, Darlinghurst, NSW 2010, Australia
(Warner) Cabrini Hospital, 183 Wattletree Road, Malvern, Vic. 3144, Australia
(Williams) Family Cancer Clinic, St. Vincent's Hospital, Darlinghurst, NSW 2010, Australia
(Wilson) Medical Psychology Research Unit, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
(Bowtell) Cancer Genomics and Biochemistry Laboratory, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Vic. 3002, Australia
(DeFazio) Obstetrics and Gynaecology, Westmead Hospital, University of Sydney, NSW 2006, Australia
(Peto) Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
(Justenhoven, Brauch) University of Tuebingen, 72074 Tuebingen, Germany (Easton, Thompson) CR-UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom (Pooley, Dunning, Pharoah, Morrison, Field, Ahmed, Healey, Ponder, Luccarini, Conroy, Shah, Munday, Jordan, Perkins, West, Redman, Driver) Department of Oncology, University of Cambridge, Cambridge CB1 8RN, United Kingdom (Ballinger, Cox) Perlegen Sciences, Inc., 2021 Stierlin Court, Mountain View, CA 94043, United States (Struewing, Zhang) Laboratory of Population Genetics, US National Cancer Institute, Bethesda, MD 20892, United States (Luben, Wareham, Day) EPIC, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom (Bowman) MRC Dunn Clinical Nutrition Centre, Cambridge CB2 0XY, United Kingdom (Meyer, Ponder) Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, United Kingdom (Haiman, Henderson) Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States (Kolonel, Le Marchand) Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, United States (Brennan, Gaborieau, Odefrey) International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon 69008, France (Sangrajrang) National Cancer Institute, Bangkok 10400, Thailand (Shen, Wu, Wang) Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan (Republic of China) (Eccles) Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton SO16 5YA, United Kingdom (Evans) Regional Genetic Service, St. Mary's Hospital, Manchester M13 0JH, United Kingdom (Peto) London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom (Fletcher, Johnson) Breakthrough Breast Cancer Research Centre, London SW3 6JB, United Kingdom (Seal, Stratton, Rahman) Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom (Stratton) Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom (Chenevix-Trench, Spurdle, Beesley, Chen, Bowtell, Green, DeFazio, Gertig, Webb) Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia (Bojesen, Nordestgaard) Department of Clinical Biochemistry, Herlev and Bispebjerg University Hospitals, University of Copenhagen, DK-2730 Herlev, Denmark (Axelsson) Department of Breast Surgery, Herlev and Bispebjerg University Hospitals, University of Copenhagen, DK-2730 Herlev, Denmark (Garcia-Closas, Brinton) Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, United States (Chanock) Advanced Technology Center, National Cancer Institute, Gaithersburg, MD 20877, United States (Lissowska) Cancer Center, M. Sklodowska-Curie Institute of Oncology, Warsaw 02781, Poland (Peplonska) Nofer Institute of Occupational Medicine, Lodz 90950, Poland (Nevanlinna, Fagerholm, Eerola) Departments of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki 00029, Finland (Eerola) Department of Oncology, Helsinki University Central Hospital, Helsinki 00029, Finland (Kang, Yoo, Noh) Seoul National University, College of Medicine, Seoul 151-742, South Korea (Yoo) National Cancer Center, Goyang 411-769, South Korea (Ahn) Ulsan University, College of Medicine, Ulsan 680-749, South Korea (Hunter, Cox) Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Ave., Boston, MA 02115, United States (Hunter, Hankinson) Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Ave., Boston, MA 02115, United States (Hall, Wedren) Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-171 77, Sweden (Liu, Low) Population Genetics, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore (Bogdanova) Department of Radiation Oncology, Hannover Medical School, D-30625 Hannover, Germany (Bogdanova, Schurmann, Dork) Department of Gynecology and Obstetrics, Hannover Medical School, D-30625 Hannover, Germany (Tollenaar) Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, Netherlands (Jacobi) Department of Medical Decision Making, Leiden University Medical Center, 2333 ZA Leiden, Netherlands (Devilee) Departments of Human Genetics and Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands (Klijn) Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel Den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, Netherlands (Sigurdson, Doody) Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, United States (Alexander) Environmental Health Sciences, University of Minnesota, Minneapolis, MN 55455, United States (Cox, Brock, MacPherson) Institute for Cancer Studies, Sheffield University Medical School, Sheffield S10 2RX, United Kingdom (Reed) Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield S10 2RX, United Kingdom (Couch, Goode, Olson) Mayo Clinic, College of Medicine, Rochester, MN 55905, United States (Meijers-Heijboer) VU University Medical Center, 1007 MB Amsterdam, Netherlands (Meijers-Heijboer, Van Den Ouweland) Department of Clinical Genetics, Erasmus University, Rotterdam NL-3015-GE, Netherlands (Uitterlinden, Rivadeneira) Department of Internal Medicine, Erasmus University, Rotterdam NL-3015-GE, Netherlands (Milne, Ribas, Gonzalez-Neira, Benitez) Spanish National Cancer Centre (CNIO), Madrid E-28029, Spain (Hopper, Southey) Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Carlton, Vic. 3053, Australia (McCredie) Department of Preventive and Social Medicine, University of Otago, Dunedin 9001, New Zealand (Giles) Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Vic. 3053, Australia (Schroen) Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Vic. 3052, Australia (Justenhoven, Brauch) Dr. Margarete Fischer-Bosch-Institute of Clinical Pharamcology, 70376 Stuttgart, Germany (Hamann) Deutsches Krebsforschungszentrum, Heidelberg 69120, Germany (Ko) Evangelische Kliniken Bonn gGmbH Johanniter Krankenhaus, 53113 Bonn, Germany (Chenevix-Trench, Hopper, McCredie, Southey, Giles, Aghmesheh, Amor, Andrews, Antill, Armes, Armitage, Arnold, Balleine, Begley, Beilby, Bennett, Bennett, Berry, Blackburn, Brennan, Brown, Buckley, Burke, Butow, Byron, Callen, Campbell, Clarke, Colley, Cotton, Cui, Culling, Cummings, Dawson, Dixon, Dobrovic, Dudding, Edkins, Eisenbruch, Farshid, Fawcett, Field, Firgaira, Fleming, Forbes, Friedlander, Gaff, Gardner, Gattas, George, Gill, Goldblatt, Greening, Grist, Haan, Harris, Hart, Hayward, Humphrey, Jenkins, Jones, Kefford, Kirk, Kollias, Kovalenko, Lakhani, Leary, Lim, Lindeman, Lipton, Lobb, Maclurcan, Mann, Marsh, McKay, Anne McLachlan, Meiser, Milne, Mitchell, Newman, O'Loughlin, Osborne, Peters, Phillips, Price, Reeve, Reeve, Richards, Rinehart, Robinson, Rudzki, Salisbury, Sambrook, Saunders, Scott, Scott, Scott, Seshadri, Shelling, Spurdle, Suthers, Taylor, Tennant, Thorne, Townshend, Tucker, Tyler, Venter, Visvader, Walpole, Ward, Waring, Warner, Warren, Watson, Williams, Wilson, Winship, Young, Bowtell, Green, DeFazio, Gertig, Webb) Peter MacCallum Cancer Centre, Melbourne, Vic. 3002, Australia (Mannermaa, Kosma, Kataja, Hartikainen) Insitute of Clinical Medicine, Pathology and Forensic Medicine, University of Kuopio, Kuopio FIN-70210, Finland (Mannermaa, Kosma, Hartikainen) Departments of Oncology and Pathology, University Hospital of Kuopio, Kuopio FIN-70211, Finland (Kataja) Department of Oncology, Vaasa Central Hospital, Vaasa 65130, Finland (Aghmesheh) Oncology Research Centre, Prince of Wales Hospital, Randwick, NSW 2031, Australia (Amor) Genetic Health Services Victoria, Royal Children's Hospital, Melbourne, Vic. 3050, Australia (Andrews, Bennett, Meiser, Tucker, Tyler) Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, NSW 2031, Australia (Antill, Dawson, Phillips, Scott) Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Vic. 3002, Australia (Armes) Anatomical Pathology, Royal Women's Hospital, Carlton, Vic. 3053, Australia (Armitage, Arnold, Jones) Molecular Genetics Laboratory, Royal Brisbane and Women's Hospital, Herston, QLD 4029, Australia (Balleine) Departments of Translational and Medical Oncology, Westmead Hospital, Westmead, NSW 2145, Australia (Begley) Cancer Biology Laboratory, TVW Institute for Child Health Research, Subiaco, WA 6008, Australia (Beilby) Pathology Centre, Queen Elizabeth Medical Centre, Nedlands, WA 6009, Australia (Bennett) Silverton Place, 101 Wickham Terrace, Brisbane, QLD 4000, Australia (Berry) Department of Public Health and Community Medicine, University of Sydney, Sydney, NSW 2006, Australia (Blackburn) John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia (Brennan) NSW Breast Cancer Institute, PO Box 143, Westmead, NSW 2145, Australia (Brown) Department of Biochemistry, University of Queensland, St. Lucia, QLD 4072, Australia (Buckley) Molecular and Cytogenetics Unit, Prince of Wales Hospital, Randwick, NSW 2031, Australia (Burke, Humphrey) Royal Hobart Hospital, GPO Box 1061L, Hobart, Tasmania 7001, Australia (Butow) Medical Psychology Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2204, Australia (Byron) Australian Genome Research Facility, Walter and Eliza Hall Medical Research Institute, Royal Melbourne Hospital, Parkville, Vic. 3050, Australia (Callen) Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide/Hanson Institute, Rundle Mall, PO Box 14, SA 5000, Australia (Campbell, Thorne) Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Vic. 3002, Australia (Chenevix-Trench, Hayward, Spurdle, Green, Webb) Queensland Institute of Medical Research, Herston, QLD 4006, Australia (Clarke, Mann) Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia (Colley) Department of Clinical Genetics, Liverpool Health Service, PO Box 103, Liverpool, NSW 2170, Australia (Cotton) Mutation Research Centre, St. Vincent's Hospital, Victoria Parade, Fitzroy, Vic. 3065, Australia (Southey, Cui, Milne) Centre for Genetic Epidemiology, University of Melbourne, 723 Swanston Street, Carlton, Vic. 3053, Australia (Culling) Molecular and Clinical Genetics, Building 65, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia (Cummings) Department of Pathology, University of Queensland Medical School, Herston, NSW 4006, Australia (Dixon) Central Regional Genetic Services, Wellington Hospital, Private bag 7902, Wellington South 6039, New Zealand (Dobrovic, Waring) Molecular Department of Pathology, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, Vic. 3002, Australia (Dudding, Scott) Hunter Genetics, Hunter Area Health Service, Waratah, NSW 2310, Australia (Edkins) Clinical Chemistry, Princess Margret Hospital for Children, Box D184, Perth, WA 6001, Australia (Eisenbruch) Department of Multicultural Health, University of Sydney, NSW 2052, Australia (Farshid) Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia (Fawcett) Family Cancer Clinic, Monash Medical Centre, Clayton, Vic. 3168, Australia (Field) Faculty of Medicine, Royal North Shore Hospital, Vindin House, St Leonards, NSW 2065, Australia (Firgaira, Grist, Seshadri) Department of Haematology, Flinders Medical Centre, Bedford Park, SA 5042, Australia (Fleming) Eskitis Institute of Cell and Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University, Nathan, QLD 4111, Australia (Forbes) Surgical Oncology, University of Newcastle, Newcastle Mater Hospital, Waratah, NSW 2298, Australia (Friedlander) Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW 2031, Australia (Gaff, Gardner) Victorian Clinical Genetics Service, Royal Melbourne Hospital, Parkville, Vic. 3052, Australia (Gattas) Queensland Clinical Genetic Service, Royal Children's Hospital, Bramston Terrace, Herston, QLD 4020, Australia (George) Clinical Biochemistry Unit, Canterbury Health Labs., PO Box 151, Christchurch 8140, New Zealand (Gill) Department of Surgery, Royal Adelaide Hospital, Adelaide, SA 5000, Australia (Goldblatt, Townshend, Walpole) Genetic Services of WA, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, WA 6008, Australia (Greening) Wollongong Hereditary Cancer Clinic, Wollongong Public Hospital, Private Mail Bag 8808, South Coast Mail Centre, NSW 2521, Australia (Haan, Suthers) Department of Medical Genetics, Women's and Children's Hospital, North Adelaide, SA 5006, Australia (Harris, McKay, Mitchell, Young) Familial Cancer Clinic, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Vic. 3002, Australia (Hart) Breast and Ovarian Cancer Genetics, Monash Medical Centre, 871 Centre Road, Bentleigh East, Vic. 3165, Australia (Hopper, Osborne, Gertig) Centre for Molecular Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Vic. 3010, Australia (Jenkins) School of Population Health, University of Melbourne, 723 Swanston Street, Carlton, Vic. 3053, Australia (Kefford) Medical Oncology, Westmead Hospital, Westmead, NSW 2145, Australia (Kirk, Leary) Familial Cancer Service, Department of Medicine, Westmead Hospital, Westmead, NSW 2145, Australia (Kollias) Breast Endocrine and Surgical Unit, Royal Adelaide Hospital, North Terrace, SA 5000, Australia (Kovalenko) Molecular Pathology Department, Southern Cross Pathology, Monash Medical Centre, Clayton, Vic. 3168, Australia (Lakhani) Molecular and Cellular Pathology, University of Queensland, Herston, QLD 4006, Australia (Lim, Tennant) Department of Psychological Medicine, Royal North Shore Hospital, St Leonards, NSW 2065, Australia (Lindeman) Breast Cancer Laboratory, Walter and Eliza Hall Institute, PO Royal Melbourne Hospital, Parkville, Vic. 3050, Australia (Lipton) Medical Oncology and Clinical Haematology Unit, Western Hospital, Footscray, Vic. 3011, Australia (Lobb) WA Centre for Cancer, Edith Cowan University, Churchlands, WA 6018, Australia (Maclurcan, Price) Department of Psychological Medicine, University of Sydney, NSW 2006, Australia (Marsh) Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW 2065, Australia (McCredie) Cancer Epidemiology Research Unit, NSW Cancer Council, 153 Dowling Street, Woolloomooloo, NSW 2011, Australia (Anne McLachlan) Department of Oncology, St. Vincent's Hospital, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia (Newman) School of Public Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia (O'Loughlin, Warren, Watson) St. Vincent's Breast Clinic, PO Box 4751, Toowoomba, QLD 4350, Australia (Peters) Radiation Oncology, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, Vic. 3002, Australia (Reeve, Winship) Genetic Services, Auckland Hospital, Private Bag 92024, Auckland 1142, New Zealand (Reeve) Cancer Genetics Laboratory, University of Otago, PO Box 56, Dunedin 9054, New Zealand (Richards) Department of Cytogenetics and Molecular Genetics, Women and Children's Hospital, Adelaide, SA 5006, Australia (Rinehart) Hancock Family Breast Cancer Foundation, PO Locked Bag 2, West Perth, WA 6005, Australia (Robinson) Oncology Service, Christchurch Hospital, Private Bag 4710, Christchurch 8140, New Zealand (Rudzki) Molecular Pathology Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia (Salisbury) Section of Cytology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW 2145, Australia (Saunders) School of Surgery and Pathology, QE11 Medical Centre, M block, Nedlands, WA 6907, Australia (Scott) South View Clinic, South Street, Kogarah, NSW 2217, Australia (Shelling) Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand (Taylor) Department of Radiology, Royal Perth Hospital, Box X2213, Perth, WA 6011, Australia (Venter) Murdoch Institute, Royal Children's Hospital, Parkville, Vic. 3050, Australia (Visvader) Molecular Genetics of Cancer Division, Walter and Eliza Hall Medical Research Institute, Royal Melbourne Hospital, Parkville, Vic. 3050, Australia (Ward) Department of Medical Oncology, St. Vincents Hospital, Darlinghurst, NSW 2010, Australia (Warner) Cabrini Hospital, 183 Wattletree Road, Malvern, Vic. 3144, Australia (Williams) Family Cancer Clinic, St. Vincent's Hospital, Darlinghurst, NSW 2010, Australia (Wilson) Medical Psychology Research Unit, Royal North Shore Hospital, St Leonards, NSW 2065, Australia (Bowtell) Cancer Genomics and Biochemistry Laboratory, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Vic. 3002, Australia (DeFazio) Obstetrics and Gynaecology, Westmead Hospital, University of Sydney, NSW 2006, Australia (Peto) Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom (Justenhoven, Brauch) University of Tuebingen, 72074 Tuebingen, Germany |
Issue Date: | 17-Jul-2007 | Copyright year: | 2007 | Publisher: | Nature Publishing Group | Place of publication: | United Kingdom | Publication information: | Nature. 447 (7148) (pp 1087-1093), 2007. Date of Publication: 28 Jun 2007. | Journal: | Nature | Abstract: | Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r2> 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach. ©2007 Nature Publishing Group. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/nature05887 | PubMed URL: | 17529967 [http://www.ncbi.nlm.nih.gov/pubmed/?term=17529967] | ISSN: | 0028-0836 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/26714 | Type: | Article |
| Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.