Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/26827
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dc.contributor.authorFriedlander M.en
dc.contributor.authorRussell P.en
dc.contributor.authorLinks M.en
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dc.contributor.authorHill J.en
dc.contributor.authorByth K.en
dc.contributor.authorJaworski R.en
dc.contributor.authorHarnett P.en
dc.contributor.authorWain G.en
dc.contributor.authorWard B.en
dc.contributor.authorPapadimos D.en
dc.contributor.authorCrandon A.en
dc.contributor.authorCummings M.en
dc.contributor.authorHorwood K.en
dc.contributor.authorObermair A.en
dc.contributor.authorPerrin L.en
dc.contributor.authorWyld D.en
dc.contributor.authorNicklin J.en
dc.contributor.authorDavy M.en
dc.contributor.authorOehler M.K.en
dc.contributor.authorHall C.en
dc.contributor.authorDodd T.en
dc.contributor.authorHealy T.en
dc.contributor.authorPittman K.en
dc.contributor.authorHenderson D.en
dc.contributor.authorMiller J.en
dc.contributor.authorPierdes J.en
dc.contributor.authorBlomfield P.en
dc.contributor.authorChallis D.en
dc.contributor.authorMcIntosh R.en
dc.contributor.authorParker A.en
dc.contributor.authorBrown B.en
dc.contributor.authorRome R.en
dc.contributor.authorAllen D.en
dc.contributor.authorGrant P.en
dc.contributor.authorHyde S.en
dc.contributor.authorLaurie R.en
dc.contributor.authorRobbie M.en
dc.contributor.authorHealy D.en
dc.contributor.authorJobling T.en
dc.contributor.authorManolitsas T.en
dc.contributor.authorMcNealage J.en
dc.contributor.authorRogers P.en
dc.contributor.authorSusil B.en
dc.contributor.authorSumithran E.en
dc.contributor.authorSimpson I.en
dc.contributor.authorPhillips K.en
dc.contributor.authorRischin D.en
dc.contributor.authorFox S.en
dc.contributor.authorJohnson D.en
dc.contributor.authorLade S.en
dc.contributor.authorLoughrey M.en
dc.contributor.authorO'Callaghan N.en
dc.contributor.authorMurray W.en
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dc.contributor.authorLeung Y.en
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dc.contributor.authorPurdie D.en
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dc.contributor.authorCampbell I.en
dc.contributor.authorCheasley D.en
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dc.contributor.authorAllan P.E.en
dc.contributor.authorAlsop K.en
dc.contributor.authorAnanda S.en
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dc.contributor.authorHendley J.en
dc.contributor.authorHo G.-Y.en
dc.contributor.authorHuntsman D.G.en
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dc.contributor.authorJobling T.W.en
dc.contributor.authorKalli K.R.en
dc.contributor.authorKaufmann S.H.en
dc.contributor.authorKennedy C.J.en
dc.contributor.authorKobel M.en
dc.contributor.authorLe Page C.en
dc.contributor.authorMcNally O.M.en
dc.contributor.authorMcAlpine J.N.en
dc.contributor.authorMileshkin L.en
dc.contributor.authorJan Pymanen
dc.contributor.authorRahimi K.en
dc.contributor.authorSamimi G.en
dc.contributor.authorSharma R.en
dc.contributor.authorStephens A.N.en
dc.contributor.authorTraficante N.en
dc.contributor.authorAntill Y.C.en
dc.contributor.authorScott C.L.en
dc.contributor.authorCampbell I.G.en
dc.contributor.authorGorringe K.L.en
dc.contributor.authorKang E.Y.en
dc.contributor.authorLePage C.en
dc.contributor.authorda Cunha Torres M.en
dc.contributor.authorRowley S.en
dc.contributor.authorSalazar C.en
dc.contributor.authorXing Z.en
dc.contributor.authorAllan P.en
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dc.contributor.authorKelemen L.E.en
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dc.contributor.authorGoodman M.T.en
dc.contributor.authorGoode E.L.en
dc.contributor.authorDeen S.en
dc.contributor.authorPharoah P.D.P.en
dc.contributor.authorBrenton J.D.en
dc.contributor.authorSieh W.en
dc.contributor.authorMateoiu C.en
dc.contributor.authorSundfeldt K.en
dc.contributor.authorCook L.S.en
dc.contributor.authorLe N.D.en
dc.contributor.authorBowtell D.en
dc.contributor.authorGreen A.en
dc.contributor.authorWebb P.en
dc.contributor.authorGertig D.en
dc.contributor.authorMoore S.en
dc.contributor.authorHung J.en
dc.contributor.authorHarrap K.en
dc.contributor.authorSadkowsky T.en
dc.contributor.authorPandeya N.en
dc.contributor.authorMalt M.en
dc.contributor.authorMellon A.en
dc.contributor.authorRobertson R.en
dc.contributor.authorBergh T.V.en
dc.contributor.authorJones M.en
dc.contributor.authorMackenzie P.en
dc.contributor.authorMaidens J.en
dc.contributor.authorNattress K.en
dc.contributor.authorChiew Y.E.en
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dc.contributor.authorAlexander B.en
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dc.contributor.authorBrown S.en
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dc.contributor.authorGreen L.en
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dc.contributor.authorFerguson K.en
dc.contributor.authorMartin K.en
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dc.contributor.authorRanieri B.en
dc.contributor.authorWhite J.en
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dc.contributor.authorMamers P.en
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dc.contributor.authorGiles D.en
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dc.contributor.authorBrooks J.en
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dc.contributor.authorKirsten F.en
dc.contributor.authorRutovitz J.en
dc.contributor.authorClingan P.en
dc.contributor.authorGlasgow A.en
dc.contributor.authorProietto A.en
dc.contributor.authorBraye S.en
dc.contributor.authorOtton G.en
dc.contributor.authorShannon J.en
dc.contributor.authorBonaventura T.en
dc.contributor.authorStewart J.en
dc.contributor.authorBegbie S.en
dc.contributor.authorBell D.en
dc.contributor.authorBaron-Hay S.en
dc.contributor.authorFerrier A.en
dc.contributor.authorGard G.en
dc.contributor.authorNevell D.en
dc.contributor.authorPavlakis N.en
dc.contributor.authorValmadre S.en
dc.contributor.authorYoung B.en
dc.contributor.authorCamaris C.en
dc.contributor.authorCrouch R.en
dc.contributor.authorEdwards L.en
dc.contributor.authorHacker N.en
dc.contributor.authorMarsden D.en
dc.contributor.authorRobertson G.en
dc.contributor.authorBeale P.en
dc.contributor.authorBeith J.en
dc.contributor.authorCarter J.en
dc.contributor.authorDalrymple C.en
dc.contributor.authorHoughton R.en
dc.date.accessioned2021-05-14T08:56:48Zen
dc.date.available2021-05-14T08:56:48Zen
dc.date.copyright2021en
dc.date.created20210224en
dc.date.issued2021-02-24en
dc.identifier.citationModern Pathology. 34 (1) (pp 194-206), 2021. Date of Publication: January 2021.en
dc.identifier.issn0893-3952en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/26827en
dc.description.abstractTP53 mutations are implicated in the progression of mucinous borderline tumors (MBOT) to mucinous ovarian carcinomas (MOC). Optimized immunohistochemistry (IHC) for TP53 has been established as a proxy for the TP53 mutation status in other ovarian tumor types. We aimed to confirm the ability of TP53 IHC to predict TP53 mutation status in ovarian mucinous tumors and to evaluate the association of TP53 mutation status with survival among patients with MBOT and MOC. Tumor tissue from an initial cohort of 113 women with MBOT/MOC was stained with optimized IHC for TP53 using tissue microarrays (75.2%) or full sections (24.8%) and interpreted using established criteria as normal or abnormal (overexpression, complete absence, or cytoplasmic). Cases were considered concordant if abnormal IHC staining predicted deleterious TP53 mutations. Discordant tissue microarray cases were re-evaluated on full sections and interpretational criteria were refined. The initial cohort was expanded to a total of 165 MBOT and 424 MOC for the examination of the association of survival with TP53 mutation status, assessed either by TP53 IHC and/or sequencing. Initially, 82/113 (72.6%) cases were concordant using the established criteria. Refined criteria for overexpression to account for intratumoral heterogeneity and terminal differentiation improved concordance to 93.8% (106/113). In the expanded cohort, 19.4% (32/165) of MBOT showed evidence for TP53 mutation and this was associated with a higher risk of recurrence, disease-specific death, and all-cause mortality (overall survival: HR = 4.6, 95% CI 1.5-14.3, p = 0.0087). Within MOC, 61.1% (259/424) harbored a TP53 mutation, but this was not associated with survival (overall survival, p = 0.77). TP53 IHC is an accurate proxy for TP53 mutation status with refined interpretation criteria accounting for intratumoral heterogeneity and terminal differentiation in ovarian mucinous tumors. TP53 mutation status is an important biomarker to identify MBOT with a higher risk of mortality.Copyright © 2020, The Author(s), under exclusive licence to United States & Canadian Academy of Pathology.en
dc.languageEnglishen
dc.languageenen
dc.publisherSpringer Natureen
dc.relation.ispartofModern Pathologyen
dc.titleRefined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses.en
dc.typeArticleen
dc.type.studyortrialObservational study (cohort, case-control, cross sectional or survey)-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41379-020-0618-9en
dc.publisher.placeUnited Statesen
dc.identifier.pubmedid32724153 [http://www.ncbi.nlm.nih.gov/pubmed/?term=32724153]en
dc.identifier.source2005691938en
dc.identifier.institution(Kang, Kobel, Kobel) Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada (LePage, Mes-Masson, Mes-Masson, Provencher, Provencher, Rahimi) Centre de recherche du Centre hospitalier de l'Universite de Montreal, Montreal, QC, Canada (LePage, Mes-Masson, Mes-Masson, Provencher, Provencher, Rahimi) Centre hospitalier de l'Universite de Montreal, Montreal, QC, Canada (Wakefield, Scott, Wakefield) Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia (Kelemen) Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States (Fasching) Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany (Doherty) Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT, United States (Goodman) Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, CA, United States (Goode) Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States (Deen) Department of Histopathology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom (Pharoah) Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom (Brenton) Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom (Sieh) Department of Genetics and Genomic Sciences, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mateoiu) Department of Pathology and Cytology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Sundfeldt) Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (Sundfeldt) Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden (Cook) University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM, United States (Le, Gilks, Huntsman, Gilks, Huntsman) Cancer Control Research, BC Cancer Research Centre, Vancouver, BC, Canada (Anglesio, Anglesio) Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada (Gilks, Huntsman, Gilks, Huntsman) British Columbia's Ovarian Cancer Research (OVCARE) Program, Vancouver General Hospital, Vancouver, BC, Canada (Gilks, Huntsman, Gilks, Huntsman) Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada (Kennedy, DeFazio, DeFazio) Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia (Kaufmann) Division of Oncology Research, Mayo Clinic, Rochester, MN, United States (Churchman, Gourley, Churchman) Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Edinburgh Centre, MRC IGMM, University of Edinburgh, Edinburgh, United Kingdom (Stephens) Hudson Institute of Medical Research, Clayton, VIC, Australia (Meagher, Ramus) School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, NSW, Australia (Meagher, Ramus) Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, NSW, Australia (Antill, Antill) Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia (Antill, Antill) Cabrini Health, Malvern, VIC, Australia (Antill, Antill) Frankston Hospital, Frankston, VIC, Australia (Scott) The Royal Women's Hospital, Parkville, VIC, Australia (Bowtell, Traficante, Fereday, Bowes, Galletta, Giles, Hendley, Alsop, Phillips, Rischin, Fox, Johnson, Lade, Loughrey, O'Callaghan, Murray) Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia (Bowtell, Waring) Department of Pathology, University of Melbourne, Parkville, VIC 3052, Australia (Bowtell) Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia (Bowtell) Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3052, Australia (Bowtell) Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0HS, United Kingdom (Chenevix-Trench, Green, Webb, Moore, Harrap, Sadkowsky, Pandeya, Malt, Alexander, Ashover, Brown, Corrish, Green, Jackman, Ferguson, Martin, Martyn, Ranieri, Purdie, Whiteman) QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia (DeFazio, Hung, Chiew) Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia (DeFazio, Brand, Harnett, Sharma) The University of Sydney, Sydney, NSW 2006, Australia (DeFazio, Stenlake, Sullivan) Department of Gynaecological Oncology, Westmead Hospital, Sydney, NSW 2145, Australia (Gertig) Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC 3052, Australia (Mellon, Robertson, Proietto, Braye, Otton) John Hunter Hospital, Lookout Road, New Lambton, NSW 2305, Australia (Bergh, Jones, Mackenzie, Camaris, Crouch, Edwards, Hacker, Marsden, Robertson) Royal Hospital for Women, Barker Street, Randwick, NSW 2031, Australia (Maidens, Bell, Baron-Hay, Ferrier, Gard, Nevell, Pavlakis, Valmadre, Young) Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, Australia (Nattress, Beale, Beith, Carter, Dalrymple, Houghton, Russell) Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia (White, Davy, Oehler, Hall, Dodd) Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia (Jayde, Blomfield, Challis, McIntosh, Parker) Royal Hobart Hospital, 48 Liverpool St, Hobart, TAS 7000, Australia (Mamers, Healy, Jobling, Manolitsas, McNealage, Rogers, Susil, Sumithran, Simpson) Monash Medical Centre, 246 Clayton Rd, Clayton, VIC 3168, Australia (Schmidt, Shirley, Viduka, Tran, Bilic, Glavinas, Zeps) Western Australian Research Tissue Network (WARTN), St John of God Pathology, 23 Walters Drive, Osborne Park, WA 6017, Australia (Ball, Young, Hammond, Leung, McCartney) Women and Infant's Research Foundation, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, WA 6008, Australia (Brooks) St John of God Hospital, 12 Salvado Rd, Subiaco, WA 6008, Australia (Stuart-Harris) Canberra Hospital, Garran, ACT 2605, Australia (Kirsten) Bankstown Cancer Centre, Bankstown Hospital, 70 Eldridge Road, Bankstown, NSW 2200, Australia (Rutovitz) Northern Haematology & Oncology Group, Integrated Cancer Centre, 185 Fox Valley Road, Wahroonga, NSW 2076, Australia (Clingan, Glasgow) Illawarra Shoalhaven Local Health District, Wollongong Hospital, Level 4 Lawson House, Wollongong, NSW 2500, Australia (Shannon) Nepean Hospital, Derby Street, Kingswood, NSW 2747, Australia (Bonaventura, Stewart) Newcastle Mater Misericordiae Hospital, Edith Street, Waratah, NSW 2298, Australia (Begbie) Port Macquarie Base Hospital, Wrights Road, Port Macquarie, NSW 2444, Australia (Friedlander) Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2031, Australia (Links) St George Hospital, Gray Street, Kogarah, NSW 2217, Australia (Grygiel) St Vincent's Hospital, 390 Victoria Street, Darlinghurst, NSW 2010, Australia (Hill) Wagga Wagga Base Hospital, Wagga Wagga, NSW 2650, Australia (Brand, Byth, Harnett, Wain) Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, Sydney, NSW 2145, Australia (Jaworski, Sharma) Department of Pathology, Westmead Clinical School, Westmead Hospital, The University of Sydney, Sydney, NSW 2006, Australia (Ward, Papadimos) Mater Misericordiae Hospital, Raymond Terrace, South Brisbane, QLD 4101, Australia (Crandon, Cummings, Horwood, Obermair, Perrin, Wyld, Nicklin) The Royal Brisbane and Women's Hospital, Butterfield Street, Herston, QLD 4006, Australia (Nicklin) Wesley Hospital, 451 Coronation Drive, Auchenflower, QLD 4066, Australia (Healy, Pittman, Henderson) Burnside Hospital, 120 Kensington Road, Toorak Gardens, SA 5065, Australia (Henderson) Flinders Medical Centre, Flinders Drive, Bedford Park, SA 5042, Australia (Miller, Pierdes) Queen Elizabeth Hospital, 28 Woodville Road, Woodville South, SA 5011, Australia (Brown, Rome) Freemasons Hospital, 20 Victoria Parade, East Melbourne, VIC 3002, Australia (Allen, Grant, Hyde, Laurie, Robbie) Mercy Hospital for Women, 163 Studley Road, Heidelberg, VIC 3084, Australia (Billson, Pyman, Neesham, Quinn) The Royal Women's Hospital, Parkville, VIC 3052, Australia (Underhill) Border Medical Oncology, Wodonga, VIC 3690, Australia (Bell) Andrew Love Cancer Centre, 70 Swanston Street, Geelong, VIC 3220, Australia (Ng) Ballarat Base Hospital, Drummond Street North, Ballarat, VIC 3350, Australia (Blum) Bendigo Health Care Group, 62 Lucan Street, Bendigo, VIC 3550, Australia (Ganju) Peninsula Health, 2 Hastings Road, Frankston, VIC 3199, Australia (Buck) Mount Hospital, 150 Mounts Bay Road, Perth, WA 6000, Australia (Haviv) Faculty of Medicine, Bar-Ilan University, 8 Henrietta Szold St, Safed, Israel (Cheasley, Ryland, Allan, Alsop, Ananda, Au-Yeung, Bowtell, Fereday, Fox, Hendley, Hunter, Mileshkin, Traficante, Scott, Campbell, Gorringe) Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (Wakefield, Ho, Scott) Walter and Eliza Hall Institute, Parkville, VIC, Australia (Wakefield, Au-Yeung, Bowtell, Christie, Fox, McNally, Scott, Campbell, Gorringe) The University of Melbourne, Melbourne, VIC, Australia (Ananda) Western Health, St. Albans, VIC, Australia (Anglesio, Gilks, Huntsman) University of British Columbia, Vancouver, BC, Canada (Bohm, Samimi) Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, NSW, Australia (Brand, Chiew, DeFazio, Kennedy, Sharma) Westmead Hospital, University of Sydney, Sydney, NSW, Australia (Chenevix-Trench) Queensland Institute of Medical Research, Brisbane, QLD, Australia (Christie, Scott) Royal Melbourne Hospital, Parkville, VIC, Australia (Churchman, Gourley) Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Edinburgh Centre, University of Edinburgh, Edinburgh, United Kingdom (Dudley, Fairweather, McAlpine, Stephens) Hudson Institute of Medical Research, Clayton, VIC, Australia (Hacker) The University of New South Wales, Sydney, NSW, Australia (Hadley) Royal Brisbane and Womens Hospital, Brisbane, QLD, Australia (Jobling) Monash Medical Centre, Clayton, VIC, Australia (Kalli, Kaufmann) Mayo Clinic, Rochester, MN, United States (Kobel) The University of Calgary, Calgary, AB, Canada (Mes-Masson, Provencher, Le Page, Rahimi) CRCHUM, Montreal, QC, Canada (McNally, Jan Pyman) Royal Womens Hospital, Parkville, VIC, Australia (Mes-Masson) University of Montreal, Montreal, QC, Canada (Provencher, Rahimi) Centre Hospitalier de L'Universite de Montreal, Montreal, QC, Canada (Jan Pyman) Royal Children's Hospital, Flemington, VIC, Australia (Sharma) NSW Health Pathology, Sydney, NSW, Australia (Antill) Cabrini Health, Malvern, VIC, Australia (Antill) Frankston Hospital, Frankston, VIC, Australia (Cheasley, da Cunha Torres, Rowley, Salazar, Xing, Allan, Bowtell, Traficante, Campbell, Gorringe, Cheasley, Bowtell, Gorringe) Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (Cheasley, da Cunha Torres, Salazar, Xing, Bowtell, Traficante, Campbell, Gorringe, Cheasley, Bowtell, Gorringe) Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australiaen
dc.description.addressM. Kobel, Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada. E-mail: mkoebel@ucalgary.caen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2021 Elsevier B.V., All rights reserved.en
dc.identifier.authoremailKobel M.; mkoebel@ucalgary.caen
dc.identifier.affiliationext(Kang, Kobel, Kobel) Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada-
dc.identifier.affiliationext(LePage, Mes-Masson, Mes-Masson, Provencher, Provencher, Rahimi) Centre de recherche du Centre hospitalier de l'Universite de Montreal, Montreal, QC, Canada-
dc.identifier.affiliationext(LePage, Mes-Masson, Mes-Masson, Provencher, Provencher, Rahimi) Centre hospitalier de l'Universite de Montreal, Montreal, QC, Canada-
dc.identifier.affiliationext(Wakefield, Scott, Wakefield) Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia-
dc.identifier.affiliationext(Kelemen) Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States-
dc.identifier.affiliationext(Fasching) Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany-
dc.identifier.affiliationext(Doherty) Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT, United States-
dc.identifier.affiliationext(Goodman) Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, CA, United States-
dc.identifier.affiliationext(Goode) Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States-
dc.identifier.affiliationext(Deen) Department of Histopathology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom-
dc.identifier.affiliationext(Pharoah) Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom-
dc.identifier.affiliationext(Brenton) Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom-
dc.identifier.affiliationext(Sieh) Department of Genetics and Genomic Sciences, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States-
dc.identifier.affiliationext(Mateoiu) Department of Pathology and Cytology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden-
dc.identifier.affiliationext(Sundfeldt) Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden-
dc.identifier.affiliationext(Sundfeldt) Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden-
dc.identifier.affiliationext(Cook) University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM, United States-
dc.identifier.affiliationext(Le, Gilks, Huntsman, Gilks, Huntsman) Cancer Control Research, BC Cancer Research Centre, Vancouver, BC, Canada-
dc.identifier.affiliationext(Anglesio, Anglesio) Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada-
dc.identifier.affiliationext(Gilks, Huntsman, Gilks, Huntsman) British Columbia's Ovarian Cancer Research (OVCARE) Program, Vancouver General Hospital, Vancouver, BC, Canada-
dc.identifier.affiliationext(Gilks, Huntsman, Gilks, Huntsman) Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada-
dc.identifier.affiliationext(Kennedy, DeFazio, DeFazio) Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia-
dc.identifier.affiliationext(Kaufmann) Division of Oncology Research, Mayo Clinic, Rochester, MN, United States-
dc.identifier.affiliationext(Churchman, Gourley, Churchman) Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Edinburgh Centre, MRC IGMM, University of Edinburgh, Edinburgh, United Kingdom-
dc.identifier.affiliationext(Stephens) Hudson Institute of Medical Research, Clayton, VIC, Australia-
dc.identifier.affiliationext(Meagher, Ramus) School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, NSW, Australia-
dc.identifier.affiliationext(Meagher, Ramus) Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, NSW, Australia-
dc.identifier.affiliationext(Antill, Antill) Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia-
dc.identifier.affiliationext(Antill, Antill) Cabrini Health, Malvern, VIC, Australia-
dc.identifier.affiliationext(Antill, Antill) Frankston Hospital, Frankston, VIC, Australia-
dc.identifier.affiliationext(Scott) The Royal Women's Hospital, Parkville, VIC, Australia-
dc.identifier.affiliationext(Bowtell, Traficante, Fereday, Bowes, Galletta, Giles, Hendley, Alsop, Phillips, Rischin, Fox, Johnson, Lade, Loughrey, O'Callaghan, Murray) Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia-
dc.identifier.affiliationext(Bowtell, Waring) Department of Pathology, University of Melbourne, Parkville, VIC 3052, Australia-
dc.identifier.affiliationext(Bowtell) Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia-
dc.identifier.affiliationext(Bowtell) Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3052, Australia-
dc.identifier.affiliationext(Bowtell) Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0HS, United Kingdom-
dc.identifier.affiliationext(Chenevix-Trench, Green, Webb, Moore, Harrap, Sadkowsky, Pandeya, Malt, Alexander, Ashover, Brown, Corrish, Green, Jackman, Ferguson, Martin, Martyn, Ranieri, Purdie, Whiteman) QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia-
dc.identifier.affiliationext(DeFazio, Hung, Chiew) Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia-
dc.identifier.affiliationext(DeFazio, Brand, Harnett, Sharma) The University of Sydney, Sydney, NSW 2006, Australia-
dc.identifier.affiliationext(DeFazio, Stenlake, Sullivan) Department of Gynaecological Oncology, Westmead Hospital, Sydney, NSW 2145, Australia-
dc.identifier.affiliationext(Gertig) Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC 3052, Australia-
dc.identifier.affiliationext(Mellon, Robertson, Proietto, Braye, Otton) John Hunter Hospital, Lookout Road, New Lambton, NSW 2305, Australia-
dc.identifier.affiliationext(Bergh, Jones, Mackenzie, Camaris, Crouch, Edwards, Hacker, Marsden, Robertson) Royal Hospital for Women, Barker Street, Randwick, NSW 2031, Australia-
dc.identifier.affiliationext(Maidens, Bell, Baron-Hay, Ferrier, Gard, Nevell, Pavlakis, Valmadre, Young) Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, Australia-
dc.identifier.affiliationext(Nattress, Beale, Beith, Carter, Dalrymple, Houghton, Russell) Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia-
dc.identifier.affiliationext(White, Davy, Oehler, Hall, Dodd) Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia-
dc.identifier.affiliationext(Jayde, Blomfield, Challis, McIntosh, Parker) Royal Hobart Hospital, 48 Liverpool St, Hobart, TAS 7000, Australia-
dc.identifier.affiliationext(Schmidt, Shirley, Viduka, Tran, Bilic, Glavinas, Zeps) Western Australian Research Tissue Network (WARTN), St John of God Pathology, 23 Walters Drive, Osborne Park, WA 6017, Australia-
dc.identifier.affiliationext(Ball, Young, Hammond, Leung, McCartney) Women and Infant's Research Foundation, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, WA 6008, Australia-
dc.identifier.affiliationext(Brooks) St John of God Hospital, 12 Salvado Rd, Subiaco, WA 6008, Australia-
dc.identifier.affiliationext(Stuart-Harris) Canberra Hospital, Garran, ACT 2605, Australia-
dc.identifier.affiliationext(Kirsten) Bankstown Cancer Centre, Bankstown Hospital, 70 Eldridge Road, Bankstown, NSW 2200, Australia-
dc.identifier.affiliationext(Rutovitz) Northern Haematology & Oncology Group, Integrated Cancer Centre, 185 Fox Valley Road, Wahroonga, NSW 2076, Australia-
dc.identifier.affiliationext(Clingan, Glasgow) Illawarra Shoalhaven Local Health District, Wollongong Hospital, Level 4 Lawson House, Wollongong, NSW 2500, Australia-
dc.identifier.affiliationext(Shannon) Nepean Hospital, Derby Street, Kingswood, NSW 2747, Australia-
dc.identifier.affiliationext(Bonaventura, Stewart) Newcastle Mater Misericordiae Hospital, Edith Street, Waratah, NSW 2298, Australia-
dc.identifier.affiliationext(Begbie) Port Macquarie Base Hospital, Wrights Road, Port Macquarie, NSW 2444, Australia-
dc.identifier.affiliationext(Friedlander) Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2031, Australia-
dc.identifier.affiliationext(Links) St George Hospital, Gray Street, Kogarah, NSW 2217, Australia-
dc.identifier.affiliationext(Grygiel) St Vincent's Hospital, 390 Victoria Street, Darlinghurst, NSW 2010, Australia-
dc.identifier.affiliationext(Hill) Wagga Wagga Base Hospital, Wagga Wagga, NSW 2650, Australia-
dc.identifier.affiliationext(Brand, Byth, Harnett, Wain) Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, Sydney, NSW 2145, Australia-
dc.identifier.affiliationext(Jaworski, Sharma) Department of Pathology, Westmead Clinical School, Westmead Hospital, The University of Sydney, Sydney, NSW 2006, Australia-
dc.identifier.affiliationext(Ward, Papadimos) Mater Misericordiae Hospital, Raymond Terrace, South Brisbane, QLD 4101, Australia-
dc.identifier.affiliationext(Crandon, Cummings, Horwood, Obermair, Perrin, Wyld, Nicklin) The Royal Brisbane and Women's Hospital, Butterfield Street, Herston, QLD 4006, Australia-
dc.identifier.affiliationext(Nicklin) Wesley Hospital, 451 Coronation Drive, Auchenflower, QLD 4066, Australia-
dc.identifier.affiliationext(Healy, Pittman, Henderson) Burnside Hospital, 120 Kensington Road, Toorak Gardens, SA 5065, Australia-
dc.identifier.affiliationext(Henderson) Flinders Medical Centre, Flinders Drive, Bedford Park, SA 5042, Australia-
dc.identifier.affiliationext(Miller, Pierdes) Queen Elizabeth Hospital, 28 Woodville Road, Woodville South, SA 5011, Australia-
dc.identifier.affiliationext(Brown, Rome) Freemasons Hospital, 20 Victoria Parade, East Melbourne, VIC 3002, Australia-
dc.identifier.affiliationext(Allen, Grant, Hyde, Laurie, Robbie) Mercy Hospital for Women, 163 Studley Road, Heidelberg, VIC 3084, Australia-
dc.identifier.affiliationext(Billson, Pyman, Neesham, Quinn) The Royal Women's Hospital, Parkville, VIC 3052, Australia-
dc.identifier.affiliationext(Underhill) Border Medical Oncology, Wodonga, VIC 3690, Australia-
dc.identifier.affiliationext(Bell) Andrew Love Cancer Centre, 70 Swanston Street, Geelong, VIC 3220, Australia-
dc.identifier.affiliationext(Ng) Ballarat Base Hospital, Drummond Street North, Ballarat, VIC 3350, Australia-
dc.identifier.affiliationext(Blum) Bendigo Health Care Group, 62 Lucan Street, Bendigo, VIC 3550, Australia-
dc.identifier.affiliationext(Ganju) Peninsula Health, 2 Hastings Road, Frankston, VIC 3199, Australia-
dc.identifier.affiliationext(Buck) Mount Hospital, 150 Mounts Bay Road, Perth, WA 6000, Australia-
dc.identifier.affiliationext(Haviv) Faculty of Medicine, Bar-Ilan University, 8 Henrietta Szold St, Safed, Israel-
dc.identifier.affiliationext(Cheasley, Ryland, Allan, Alsop, Ananda, Au-Yeung, Bowtell, Fereday, Fox, Hendley, Hunter, Mileshkin, Traficante, Scott, Campbell, Gorringe) Peter MacCallum Cancer Centre, Melbourne, VIC, Australia-
dc.identifier.affiliationext(Wakefield, Ho, Scott) Walter and Eliza Hall Institute, Parkville, VIC, Australia-
dc.identifier.affiliationext(Wakefield, Au-Yeung, Bowtell, Christie, Fox, McNally, Scott, Campbell, Gorringe) The University of Melbourne, Melbourne, VIC, Australia-
dc.identifier.affiliationext(Ananda) Western Health, St. Albans, VIC, Australia-
dc.identifier.affiliationext(Anglesio, Gilks, Huntsman) University of British Columbia, Vancouver, BC, Canada-
dc.identifier.affiliationext(Bohm, Samimi) Kinghorn Cancer Centre and Garvan Institute of Medical Research, Darlinghurst, NSW, Australia-
dc.identifier.affiliationext(Brand, Chiew, DeFazio, Kennedy, Sharma) Westmead Hospital, University of Sydney, Sydney, NSW, Australia-
dc.identifier.affiliationext(Chenevix-Trench) Queensland Institute of Medical Research, Brisbane, QLD, Australia-
dc.identifier.affiliationext(Christie, Scott) Royal Melbourne Hospital, Parkville, VIC, Australia-
dc.identifier.affiliationext(Churchman, Gourley) Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Edinburgh Centre, University of Edinburgh, Edinburgh, United Kingdom-
dc.identifier.affiliationext(Dudley, Fairweather, McAlpine, Stephens) Hudson Institute of Medical Research, Clayton, VIC, Australia-
dc.identifier.affiliationext(Hacker) The University of New South Wales, Sydney, NSW, Australia-
dc.identifier.affiliationext(Hadley) Royal Brisbane and Womens Hospital, Brisbane, QLD, Australia-
dc.identifier.affiliationext(Jobling) Monash Medical Centre, Clayton, VIC, Australia-
dc.identifier.affiliationext(Kalli, Kaufmann) Mayo Clinic, Rochester, MN, United States-
dc.identifier.affiliationext(Kobel) The University of Calgary, Calgary, AB, Canada-
dc.identifier.affiliationext(Mes-Masson, Provencher, Le Page, Rahimi) CRCHUM, Montreal, QC, Canada-
dc.identifier.affiliationext(McNally, Jan Pyman) Royal Womens Hospital, Parkville, VIC, Australia-
dc.identifier.affiliationext(Mes-Masson) University of Montreal, Montreal, QC, Canada-
dc.identifier.affiliationext(Provencher, Rahimi) Centre Hospitalier de L'Universite de Montreal, Montreal, QC, Canada-
dc.identifier.affiliationext(Jan Pyman) Royal Children's Hospital, Flemington, VIC, Australia-
dc.identifier.affiliationext(Sharma) NSW Health Pathology, Sydney, NSW, Australia-
dc.identifier.affiliationext(Antill) Cabrini Health, Malvern, VIC, Australia-
dc.identifier.affiliationext(Antill) Frankston Hospital, Frankston, VIC, Australia-
dc.identifier.affiliationext(Cheasley, da Cunha Torres, Rowley, Salazar, Xing, Allan, Bowtell, Traficante, Campbell, Gorringe, Cheasley, Bowtell, Gorringe) Peter MacCallum Cancer Centre, Melbourne, VIC, Australia-
dc.identifier.affiliationext(Cheasley, da Cunha Torres, Salazar, Xing, Bowtell, Traficante, Campbell, Gorringe, Cheasley, Bowtell, Gorringe) Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia-
dc.identifier.affiliationmh(Mamers, Healy, Jobling, Manolitsas, McNealage, Rogers, Susil, Sumithran, Simpson) Monash Medical Centre, 246 Clayton Rd, Clayton, VIC 3168, Australia-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptObstetrics and Gynaecology (Monash Women's)-
crisitem.author.deptVascular and Transplantation Surgery-
crisitem.author.deptOncology-
crisitem.author.deptObstetrics and Gynaecology (Monash Women's)-
crisitem.author.deptHaematology-
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