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DC Field | Value | Language |
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dc.contributor.author | Lau L.M.S. | en |
dc.contributor.author | Baber J. | en |
dc.contributor.author | Priestley P. | en |
dc.contributor.author | Dolman M.E.M. | en |
dc.contributor.author | Fleuren E.D.G. | en |
dc.contributor.author | Gauthier M.-E. | en |
dc.contributor.author | Mould E.V.A. | en |
dc.contributor.author | Gayevskiy V. | en |
dc.contributor.author | Gifford A.J. | en |
dc.contributor.author | Grebert-Wade D. | en |
dc.contributor.author | Mayoh C. | en |
dc.contributor.author | Bolanos N.A. | en |
dc.contributor.author | Khuong-Quang D.-A. | en |
dc.contributor.author | Pinese M. | en |
dc.contributor.author | Kumar A. | en |
dc.contributor.author | Barahona P. | en |
dc.contributor.author | Wilkie E.E. | en |
dc.contributor.author | Sullivan P. | en |
dc.contributor.author | Bowen-James R. | en |
dc.contributor.author | Syed M. | en |
dc.contributor.author | Martincorena I. | en |
dc.contributor.author | Abascal F. | en |
dc.contributor.author | Sherstyuk A. | en |
dc.contributor.author | Strong P.A. | en |
dc.contributor.author | Manouvrier E. | en |
dc.contributor.author | Warby M. | en |
dc.contributor.author | Thomas D.M. | en |
dc.contributor.author | Kirk J. | en |
dc.contributor.author | Tucker K. | en |
dc.contributor.author | O'Brien T. | en |
dc.contributor.author | Alvaro F. | en |
dc.contributor.author | McCowage G.B. | en |
dc.contributor.author | Dalla-Pozza L. | en |
dc.contributor.author | Gottardo N.G. | en |
dc.contributor.author | Tapp H. | en |
dc.contributor.author | Wood P. | en |
dc.contributor.author | Khaw S.-L. | en |
dc.contributor.author | Hansford J.R. | en |
dc.contributor.author | Moore A.S. | en |
dc.contributor.author | Norris M.D. | en |
dc.contributor.author | Trahair T.N. | en |
dc.contributor.author | Lock R.B. | en |
dc.contributor.author | Tyrrell V. | en |
dc.contributor.author | Haber M. | en |
dc.contributor.author | Marshall G.M. | en |
dc.contributor.author | Ziegler D.S. | en |
dc.contributor.author | Ekert P.G. | en |
dc.contributor.author | Cowley M.J. | en |
dc.contributor.author | Wong M. | en |
dc.date.accessioned | 2021-05-14T08:57:35Z | en |
dc.date.available | 2021-05-14T08:57:35Z | en |
dc.date.copyright | 2020 | en |
dc.date.created | 20210328 | en |
dc.date.issued | 2021-03-28 | en |
dc.identifier.citation | Nature Medicine. 26 (11) (pp 1742-1753), 2020. Date of Publication: November 2020. | en |
dc.identifier.issn | 1078-8956 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/26859 | en |
dc.description.abstract | The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable molecular aberrations (39.9% in WGS and RNAseq, 35.1% in WGS only and 25.0% in RNAseq only). Of these patients, 93.7% had at least one germline or somatic aberration, 71.4% had therapeutic targets and 5.2% had a change in diagnosis. WGS identified pathogenic cancer-predisposing variants in 16.2% of patients. In 76 central nervous system tumors, methylome analysis confirmed diagnosis in 71.1% of patients and contributed to a change of diagnosis in two patients (2.6%). To date, 43 patients have received a recommended therapy, 38 of whom could be evaluated, with 31% showing objective evidence of clinical benefit. Comprehensive molecular profiling resolved the molecular basis of virtually all high-risk cancers, leading to clinical benefit in some patients.Copyright © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Nature Research | en |
dc.relation.ispartof | Nature Medicine | en |
dc.title | Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer. | en |
dc.type | Article | en |
dc.type.studyortrial | Observational study (cohort, case-control, cross sectional or survey) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url= | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41591-020-1072-4 | en |
dc.publisher.place | United States | en |
dc.identifier.pubmedid | 33020650 [http://www.ncbi.nlm.nih.gov/pubmed/?term=33020650] | en |
dc.identifier.source | 2006876553 | en |
dc.identifier.institution | (Wong, Mayoh, Lau, Pinese, Kumar, Barahona, Wilkie, Sullivan, Bowen-James, Syed, Sherstyuk, Bolanos, Dolman, Fleuren, Gauthier, Mould, Gifford, Grebert-Wade, Strong, Manouvrier, Norris, Trahair, Lock, Tyrrell, Haber, Marshall, Ziegler, Ekert, Cowley) Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia (Wong, Mayoh, Lau, Pinese, Wilkie, Bolanos, Fleuren, Gifford, O'Brien, Norris, Trahair, Lock, Haber, Marshall, Ziegler, Ekert, Cowley) School of Women's and Children's Health, UNSW Sydney, Kensington, NSW, Australia (Wong, Pinese, Gayevskiy, Thomas, Cowley) Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia (Lau, Bolanos, O'Brien, Trahair, Marshall, Ziegler) Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia (Khuong-Quang, Khaw, Hansford) Children's Cancer Centre, Royal Children's Hospital, Parkville, VIC, Australia (Khuong-Quang, Khaw, Ekert) Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia (Kumar, Ekert) Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (Martincorena, Abascal) Wellcome Trust Sanger Institute, Hinxton, United Kingdom (Baber, Priestley) Hartwig Medical Foundation, Amsterdam, Netherlands (Baber, Priestley) Hartwig Medical Foundation Australia, Sydney, NSW, Australia (Gifford) Department of Anatomical Pathology, Prince of Wales Hospital, Randwick, NSW, Australia (Warby, McCowage, Dalla-Pozza) Cancer Centre for Children, The Children's Hospital Westmead, Westmead, NSW, Australia (Kirk) Familial Cancer Service, Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW, Australia (Kirk) Sydney Medical School, University of Sydney Centre for Cancer Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia (Tucker) Hereditary Cancer Centre, Prince of Wales Hospital, Randwick, NSW, Australia (Tucker) Prince of Wales Hospital Clinical School, University of New South Wales, Randwick, NSW, Australia (Alvaro) John Hunter Children's Hospital, New Lambton Heights, NSW, Australia (Gottardo) Department of Paediatric and Adolescent Oncology/Haematology, Perth Children's Hospital, Nedlands, WA, Australia (Gottardo) Brain Tumour Research Program, Telethon Kids Institute, Nedlands, WA, Australia (Tapp) Women's and Children's Hospital, Adelaide, SA, Australia (Wood) Monash Children's Hospital, Melbourne, VIC, Australia (Moore) Oncology Service, Oncology Service, Queensland Children's Hospital, Brisbane, QLD, Australia (Moore) Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia (Norris) University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Kensington, NSW, Australia | en |
dc.description.address | D.S. Ziegler, Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia. E-mail: d.ziegler@unsw.edu.au P.G. Ekert, Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia. E-mail: pekert@ccia.org.au M.J. Cowley, Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia. E-mail: mcowley@ccia.org.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2021 Elsevier B.V., All rights reserved. | en |
dc.identifier.authoremail | Cowley M.J.; mcowley@ccia.org.au Ziegler D.S.; d.ziegler@unsw.edu.au Ekert P.G.; pekert@ccia.org.au | en |
dc.description.grant | No: APP1165556 Organization: *Cancer Australia* Organization No: 501100001111 Country: Australia | en |
dc.identifier.affiliationext | (Wong, Mayoh, Lau, Pinese, Kumar, Barahona, Wilkie, Sullivan, Bowen-James, Syed, Sherstyuk, Bolanos, Dolman, Fleuren, Gauthier, Mould, Gifford, Grebert-Wade, Strong, Manouvrier, Norris, Trahair, Lock, Tyrrell, Haber, Marshall, Ziegler, Ekert, Cowley) Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia | - |
dc.identifier.affiliationext | (Wong, Mayoh, Lau, Pinese, Wilkie, Bolanos, Fleuren, Gifford, O'Brien, Norris, Trahair, Lock, Haber, Marshall, Ziegler, Ekert, Cowley) School of Women's and Children's Health, UNSW Sydney, Kensington, NSW, Australia | - |
dc.identifier.affiliationext | (Wong, Pinese, Gayevskiy, Thomas, Cowley) Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia | - |
dc.identifier.affiliationext | (Lau, Bolanos, O'Brien, Trahair, Marshall, Ziegler) Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia | - |
dc.identifier.affiliationext | (Khuong-Quang, Khaw, Hansford) Children's Cancer Centre, Royal Children's Hospital, Parkville, VIC, Australia | - |
dc.identifier.affiliationext | (Khuong-Quang, Khaw, Ekert) Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia | - |
dc.identifier.affiliationext | (Kumar, Ekert) Peter MacCallum Cancer Centre, Melbourne, VIC, Australia | - |
dc.identifier.affiliationext | (Martincorena, Abascal) Wellcome Trust Sanger Institute, Hinxton, United Kingdom | - |
dc.identifier.affiliationext | (Baber, Priestley) Hartwig Medical Foundation, Amsterdam, Netherlands | - |
dc.identifier.affiliationext | (Baber, Priestley) Hartwig Medical Foundation Australia, Sydney, NSW, Australia | - |
dc.identifier.affiliationext | (Gifford) Department of Anatomical Pathology, Prince of Wales Hospital, Randwick, NSW, Australia | - |
dc.identifier.affiliationext | (Warby, McCowage, Dalla-Pozza) Cancer Centre for Children, The Children's Hospital Westmead, Westmead, NSW, Australia | - |
dc.identifier.affiliationext | (Kirk) Familial Cancer Service, Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW, Australia | - |
dc.identifier.affiliationext | (Kirk) Sydney Medical School, University of Sydney Centre for Cancer Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia | - |
dc.identifier.affiliationext | (Tucker) Hereditary Cancer Centre, Prince of Wales Hospital, Randwick, NSW, Australia | - |
dc.identifier.affiliationext | (Tucker) Prince of Wales Hospital Clinical School, University of New South Wales, Randwick, NSW, Australia | - |
dc.identifier.affiliationext | (Alvaro) John Hunter Children's Hospital, New Lambton Heights, NSW, Australia | - |
dc.identifier.affiliationext | (Gottardo) Department of Paediatric and Adolescent Oncology/Haematology, Perth Children's Hospital, Nedlands, WA, Australia | - |
dc.identifier.affiliationext | (Gottardo) Brain Tumour Research Program, Telethon Kids Institute, Nedlands, WA, Australia | - |
dc.identifier.affiliationext | (Tapp) Women's and Children's Hospital, Adelaide, SA, Australia | - |
dc.identifier.affiliationext | (Moore) Oncology Service, Oncology Service, Queensland Children's Hospital, Brisbane, QLD, Australia | - |
dc.identifier.affiliationext | (Moore) Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia | - |
dc.identifier.affiliationext | (Norris) University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Kensington, NSW, Australia | - |
dc.identifier.affiliationmh | (Wood) Monash Children's Hospital, Melbourne, VIC, Australia | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Paediatric - Haematology-Oncology (Children's Cancer Centre) | - |
Appears in Collections: | Articles |
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