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DC Field | Value | Language |
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dc.contributor.author | Polkinghorne K.R. | en |
dc.contributor.author | Mulley W.R. | en |
dc.contributor.author | Kanellis J. | en |
dc.contributor.author | Leong K.G. | en |
dc.contributor.author | Dave V. | en |
dc.date.accessioned | 2021-05-14T08:58:19Z | en |
dc.date.available | 2021-05-14T08:58:19Z | en |
dc.date.copyright | 2020 | en |
dc.date.created | 20210324 | en |
dc.date.issued | 2021-03-24 | en |
dc.identifier.citation | Scientific reports. 10 (1) (pp 19379), 2020. Date of Publication: 09 Nov 2020. | en |
dc.identifier.issn | 2045-2322 (electronic) | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/26890 | en |
dc.description.abstract | The evidence supporting an initial mycophenolate mofetil (MMF) dose of 2 g daily in tacrolimus-treated renal transplant recipients is limited. In a non-contemporaneous single-centre cohort study we compared the incidence of leukopaenia, rejection and graft dysfunction in patients initiated on MMF 1.5 g and 2 g daily. Baseline characteristics and tacrolimus trough levels were similar by MMF group. MMF doses became equivalent between groups by 12-months post-transplant, driven by dose reductions in the 2 g group. Leukopaenia occurred in 42.4% of patients by 12-months post-transplant. MMF 2 g was associated with a 1.80-fold increased risk of leukopaenia compared to 1.5 g. Rejection occurred in 44.8% of patients by 12-months post-transplantation. MMF 2 g was associated with half the risk of rejection relative to MMF 1.5 g. Over the first 7-years post-transplantation there was no difference in renal function between groups. Additionally, the development of leukopaenia or rejection did not result in reduced renal function at 7-years post-transplant. Leukopaenia was not associated with an increased incidence of serious infections or rejection. This study demonstrates the initial MMF dose has implications for the incidence of leukopaenia and rejection. Since neither dose produced superior long-term graft function, clinical equipoise remains regarding the optimal initial mycophenolate dose in tacrolimus-treated renal transplant recipients. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | NLM (Medline) | en |
dc.relation.ispartof | Scientific Reports | - |
dc.title | Initial mycophenolate dose in tacrolimus treated renal transplant recipients, a cohort study comparing leukopaenia, rejection and long-term graft function. | en |
dc.type | Article | en |
dc.identifier.affiliation | Nephrology | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url= | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41598-020-76379-6 | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 33168923 [http://www.ncbi.nlm.nih.gov/pubmed/?term=33168923] | en |
dc.identifier.source | 633393801 | en |
dc.identifier.institution | (Dave, Polkinghorne, Leong, Kanellis, Mulley) Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, VIC, 3168, Australia (Polkinghorne, Leong, Kanellis, Mulley) Department of Medicine, Centre for Inflammatory Diseases, Monash University, Clayton, VIC, 3168, Australia (Polkinghorne) Department of Epidemiology and Preventive Medicine, Monash University, VIC, Australia | en |
dc.rights.statement | This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine | en |
dc.identifier.authoremail | Mulley W.R.; bill.mulley@monashhealth.org | en |
dc.identifier.affiliationext | (Polkinghorne, Leong, Kanellis, Mulley) Department of Medicine, Centre for Inflammatory Diseases, Monash University, Clayton, VIC, 3168, Australia | - |
dc.identifier.affiliationext | (Polkinghorne) Department of Epidemiology and Preventive Medicine, Monash University, VIC, Australia | - |
dc.identifier.affiliationmh | (Dave, Polkinghorne, Leong, Kanellis, Mulley) Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, VIC, 3168, Australia | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
crisitem.author.dept | Nephrology | - |
Appears in Collections: | Articles |
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