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Title: | An update of venetoclax and obinutuzumab in chronic lymphocytic leukemia. | Authors: | Salvaris R.;Opat S. | Monash Health Department(s): | Haematology | Institution: | (Salvaris, Opat) Department of Haematology, Monash Health, 246 Clayton Rd, Clayton, VIC 3168, Australia (Salvaris) School of Clinical Sciences at Monash Health, Monash University, Wellington Rd, Clayton, VIC 3800, Australia | Issue Date: | 20-Feb-2021 | Copyright year: | 2021 | Publisher: | Future Medicine Ltd. | Place of publication: | United Kingdom | Publication information: | Future Oncology. 17 (4) (pp 371-387), 2021. Date of Publication: February 2021. | Journal: | Future Oncology | Abstract: | In the last decade, the treatment of chronic lymphocytic leukemia (CLL) has shifted away from chemoimmunotherapy toward targeted novel agents such as small molecule inhibitors and antibodies. Here, we give an overview of the pharmacology of venetoclax and obinutuzumab and the evidence from early phase to Phase III trials that have shaped how they are used in the treatment of CLL. Venetoclax, an oral anti-apoptotic BCL-2 inhibitor, in combination with a CD20 antibody has shown superiority to chemoimmunotherapy in treatment-naive and relapsed/refractory CLL. Obinutuzumab is a novel anti-CD20 monoclonal antibody that has been safely combined with novel agents including venetoclax and Bruton tyrosine kinase inhibitors and has shown superiority over rituximab when combined with chlorambucil.Copyright © 2020 Future Medicine Ltd. | DOI: | http://monash.idm.oclc.org/login?url= http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.2217/fon-2020-0640 |
PubMed URL: | 33064021 [http://www.ncbi.nlm.nih.gov/pubmed/?term=33064021] | ISSN: | 1479-6694 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/27245 | Type: | Article |
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