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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/27376
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dc.contributor.authorMonette S.en
dc.contributor.authorHolmes E.C.en
dc.contributor.authorJolly C.J.en
dc.contributor.authorWeninger W.en
dc.contributor.authorRoediger B.en
dc.contributor.authorLee Q.en
dc.contributor.authorTikoo S.en
dc.contributor.authorCobbin J.C.A.en
dc.contributor.authorHenderson J.M.en
dc.contributor.authorJormakka M.en
dc.contributor.authorO'Rourke M.B.en
dc.contributor.authorPadula M.P.en
dc.contributor.authorPinello N.en
dc.contributor.authorHenry M.en
dc.contributor.authorWynne M.en
dc.contributor.authorSantagostino S.F.en
dc.contributor.authorBrayton C.F.en
dc.contributor.authorRasmussen L.en
dc.contributor.authorLisowski L.en
dc.contributor.authorTay S.S.en
dc.contributor.authorHarris D.C.en
dc.contributor.authorBertram J.F.en
dc.contributor.authorDowling J.P.en
dc.contributor.authorBertolino P.en
dc.contributor.authorLai J.H.en
dc.contributor.authorWu W.en
dc.contributor.authorBachovchin W.W.en
dc.contributor.authorWong J.J.-L.en
dc.contributor.authorGorrell M.D.en
dc.contributor.authorShaban B.en
dc.date.accessioned2021-05-14T09:10:52Zen
dc.date.available2021-05-14T09:10:52Zen
dc.date.copyright2018en
dc.date.created20181120en
dc.date.issued2018-11-20en
dc.identifier.citationCell. 175 (2) (pp 530-543.e24), 2018. Date of Publication: 4 October 2018.en
dc.identifier.issn0092-8674en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/27376en
dc.description.abstractThe occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans. A kidney parvovirus found in multiple laboratory mouse colonies causes spontaneous nephropathy and represents a new tool for studying chronic kidney disease.Copyright © 2018 Elsevier Inc.en
dc.languageEnglishen
dc.languageenen
dc.publisherCell Press (E-mail: subs@cell.com)en
dc.publisherCell Pressen
dc.relation.ispartofCellen
dc.titleAn Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis.en
dc.typeArticleen
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.cell.2018.08.013en
dc.publisher.placeUnited Statesen
dc.identifier.pubmedid30220458 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30220458]en
dc.identifier.source2001262512en
dc.identifier.institution(Roediger, Lee, Tikoo, Henderson, Jormakka, Pinello, Henry, Wynne, Tay, Bertolino, Wong, Gorrell, Jolly, Weninger) Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia (Cobbin, Holmes) Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia (O'Rourke) Mass Spectrometry Core Facility, University of Sydney, Sydney, NSW 2006, Australia (O'Rourke, Padula) Proteomics Core Facility, University of Technology Sydney, Ultimo, NSW 2007, Australia (Henry, Wynne) Laboratory Animal Services, University of Sydney, Sydney, NSW 2006, Australia (Santagostino, Monette) Laboratory of Comparative Pathology, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY 10065, United States (Brayton) Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States (Rasmussen) Cerberus Sciences, Thebarton, SA 5031, Australia (Lisowski) Children's Medical Research Institute, University of Sydney, Sydney, NSW 2006, Australia (Lisowski) Military Institute of Hygiene and Epidemiology, Biological Threats Identification and Countermeasure Centre, Pulawy 24-100, Poland (Harris) Centre for Transplantation and Renal Research, Westmead Institute for Medical Research, University of Sydney, NSW 2006, Australia (Bertram) Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia (Dowling) Department of Anatomical Pathology, Monash Medical Centre, Clayton, VIC 3168, Australia (Lai, Wu, Bachovchin) Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, United States (Shaban) Australian Genomics Research Facility, Parkville, VIC 3000, Australia (Shaban) Melbourne Integrative Genomics, University of Melbourne, Parkville, VIC 3010, Australia (Weninger) Discipline of Dermatology, Faculty of Medicine and Health, University of Sydney, NSW 2006, Australia (Weninger) Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia (Weninger) Department of Dermatology, Medical University of Vienna, Vienna 1090, Austriaen
dc.description.addressB. Roediger, Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia. E-mail: b.roediger@centenary.org.auen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2021 Elsevier B.V., All rights reserved.en
dc.rights.statementCopyright 2018 Elsevier B.V., All rights reserved.en
dc.subect.keywordschronic kidney disease fibrosis inclusion body nephropathy Parvoviridae parvovirus tubulointerstitial fibrosis viral metagenomicsen
dc.identifier.authoremailRoediger B.; b.roediger@centenary.org.au Weninger W.; w.weninger@centenary.org.auen
dc.description.grantNo: FL170100022 Organization: (ARC) *Australian Research Council* Organization No: 501100000923 Country: Australia Organization: *Cancer Institute NSW* Organization No: 501100001171 Country: Australia Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia No: R01 DK107309 Organization: (NIDDK) *National Institute of Diabetes and Digestive and Kidney Diseases* Organization No: 100000062 Country: United Statesen
dc.description.grantOrganization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia Organization: *Cancer Institute NSW* Organization No: 501100001171 Country: Australia No: FL170100022 Organization: (ARC) *Australian Research Council* Organization No: 501100000923 Country: Australia No: R01 DK107309 Organization: (NIDDK) *National Institute of Diabetes and Digestive and Kidney Diseases* Organization No: 100000062 Country: United Statesen
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeArticle-
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