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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/27422
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dc.contributor.authorSobey C.G.en
dc.contributor.authorPhan T.G.en
dc.contributor.authorZhang S.R.en
dc.date.accessioned2021-05-14T09:13:51Zen
dc.date.available2021-05-14T09:13:51Zen
dc.date.copyright2021en
dc.date.created20210205en
dc.date.issued2021-02-05en
dc.identifier.citationTrends in Pharmacological Sciences. 42 (2) (pp 96-105), 2021. Date of Publication: February 2021.en
dc.identifier.issn0165-6147en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/27422en
dc.description.abstractStroke is responsible for almost 6 million deaths and more than 10% of all mortalities each year, and two-thirds of stroke survivors remain disabled. With treatments for ischemic stroke still limited to clot lysis and/or mechanical removal, new therapeutic targets are desperately needed. In this review, we provide an overview of the complex mechanisms of innate and adaptive immune cell-mediated inflammatory injury, that exacerbates infarct development for several days after stroke. We also highlight the features of poststroke systemic immunodepression that commonly leads to infections and some mortalities, and argue that safe and effective therapies will need to balance pro- and anti-inflammatory mechanisms in a time-sensitive manner, to maximize the likelihood of an improved long-term outcome.Copyright © 2020 Elsevier Ltden
dc.languageenen
dc.languageEnglishen
dc.publisherElsevier Ltden
dc.relation.ispartofTrends in Pharmacological Sciencesen
dc.titleTargeting the Immune System for Ischemic Stroke.en
dc.typeReviewen
dc.type.studyortrialReview article (e.g. literature review, narrative review)-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.tips.2020.11.010en
dc.publisher.placeUnited Kingdomen
dc.identifier.pubmedid33341247 [http://www.ncbi.nlm.nih.gov/pubmed/?term=33341247]en
dc.identifier.source2010392514en
dc.identifier.institution(Zhang, Sobey) Department of Physiology, Anatomy, and Microbiology, and Centre for Cardiovascular Biology and Disease Research, School of Life Sciences, La Trobe University, Bundoora, Victoria, Australia (Phan) Clinical Trials, Imaging, and Informatics (CTI) Division, Stroke and Ageing Research (STARC), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australiaen
dc.description.addressC.G. Sobey, Department of Physiology, Anatomy, and Microbiology, and Centre for Cardiovascular Biology and Disease Research, School of Life Sciences, La Trobe University, Bundoora, Victoria, Australia. E-mail: c.sobey@latrobe.edu.auen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2021 Elsevier B.V., All rights reserved.en
dc.subect.keywordsimmune cells immunotherapy infection inflammation penumbra strokeen
dc.identifier.authoremailSobey C.G.; c.sobey@latrobe.edu.auen
dc.description.grantNo: 1079467 Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australia No: 1163282 Organization: (NHMRC) *National Health and Medical Research Council* Organization No: 501100000925 Country: Australiaen
dc.identifier.affiliationext(Zhang, Sobey) Department of Physiology, Anatomy, and Microbiology, and Centre for Cardiovascular Biology and Disease Research, School of Life Sciences, La Trobe University, Bundoora, Victoria, Australia-
dc.identifier.affiliationmh(Phan) Clinical Trials, Imaging, and Informatics (CTI) Division, Stroke and Ageing Research (STARC), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeReview-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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