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DC Field | Value | Language |
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dc.contributor.author | Tao J.J. | en |
dc.contributor.author | Scaltriti M. | en |
dc.contributor.author | Markman B. | en |
dc.date.accessioned | 2021-05-14T09:16:08Z | en |
dc.date.available | 2021-05-14T09:16:08Z | en |
dc.date.copyright | 2013 | en |
dc.date.created | 20130507 | en |
dc.date.issued | 2013-05-07 | en |
dc.identifier.citation | Current Pharmaceutical Design. 19 (5) (pp 895-906), 2013. Date of Publication: 2013. | en |
dc.identifier.issn | 1381-6128 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/27530 | en |
dc.description.abstract | The PI3K/Akt/mTOR signaling pathway plays a key role in diverse physiologic processes. It is also central to many aspects of the malignant process. Genetic phenomena that lead to constitutive pathway activation are common in human cancer; the most relevant are mutations affecting the catalytic subunit of PI3K and loss of function of the PTEN tumor suppressor. These factors have made this important cascade attractive as a potential target for cancer therapeutics. A host of inhibitors are now in various stages of development that target key nodes within the PI3K pathway. To date, however, the efficacy of these agents has fallen short of expectation, with at least one possible explanation being the presence of feedback loops and cross-talk that exists within and between PI3K and other signaling pathways. Accordingly, enthusiasm is again high as strategies employing therapeutic combinations are gaining pace, with encouraging results documented in both preclinical studies and emerging clinical trials. Here, we review the agents that have reached evaluation in early phase clinical studies of human subjects with cancer, and discuss the rationale for and use of novel drug combinations. © 2013 Bentham Science Publishers. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Bentham Science Publishers B.V. (P.O. Box 294, Bussum 1400 AG, Netherlands) | en |
dc.title | PI3K pathway inhibitors: Better not left alone. | en |
dc.type | Review | en |
dc.type.studyortrial | Review article (e.g. literature review, narrative review) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.2174/138161213804547213 | en |
dc.publisher.place | Netherlands | en |
dc.identifier.pubmedid | 22973958 [http://www.ncbi.nlm.nih.gov/pubmed/?term=22973958] | en |
dc.identifier.source | 368798487 | en |
dc.identifier.institution | (Markman) Monash Medical Centre, Southern Health, Melbourne, 3165, Australia (Markman) Monash Institute of Medical Research, Monash University, Melbourne, 3168, Australia (Tao, Scaltriti) Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, CNY 149, 13th Street, Charlestown, MA, 02129, United States (Tao, Scaltriti) Harvard Medical School, Boston, MA, United States | en |
dc.description.address | M. Scaltriti, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, CNY 149, 13th Street, Charlestown, MA, 02129, United States. E-mail: mscaltriti@partners.org | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2013 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Akt Clinical trial mTOR PI3K PI3K inhibitor PIK3CA PTEN Therapeutic combination | en |
dc.identifier.authoremail | Scaltriti M.; mscaltriti@partners.org | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Review | - |
Appears in Collections: | Articles |
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