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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Biggs B.-A. | en |
dc.contributor.author | Pasricha S.-R. | en |
dc.contributor.author | Low M. | en |
dc.contributor.author | Farrell A. | en |
dc.date.accessioned | 2021-05-14T09:17:53Z | en |
dc.date.available | 2021-05-14T09:17:53Z | en |
dc.date.copyright | 2013 | en |
dc.date.created | 20131224 | en |
dc.date.issued | 2013-12-24 | en |
dc.identifier.citation | CMAJ. 185 (17) (pp E791-E802), 2013. Date of Publication: 19 Nov 2013. | en |
dc.identifier.issn | 0820-3946 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/27612 | en |
dc.description.abstract | Background: Anemia is an important public health and clinical problem. Observational studies have linked iron deficiency and anemia in children with many poor outcomes, including impaired cognitive development; however, iron supplementation, a widely used prevent - ive and therapeutic strategy, is associated with adverse effects. Primary-school-aged children are at a critical stage in intellectual development, and optimization of their cognitive performance could have long-lasting individual and population benefits. In this study, we summarize the evidence for the benefits and safety of daily iron supplementation in primary-school-aged children. Method(s): We searched electronic databases (including MEDLINE and Embase) and other sources (July 2013) for randomized and quasirandomized controlled trials involving daily iron supplementation in children aged 5-12 years. We combined the data using random effects meta-analysis. Result(s): We identified 16 501 studies; of these, we evaluated 76 full-text papers and included 32 studies including 7089 children. Of the included studies, 31 were conducted in low- or middleincome settings. Iron supplementation improved global cognitive scores (standardized mean difference 0.50, 95% confidence interval [CI] 0.11 to 0. 90, p = 0.01), intelligence quotient among anemic children (mean difference 4.55, 95% CI 0.16 to 8.94, p = 0.04) and measures of attention and concentration. Iron supplementation also improved age-adjusted height among all children and age-adjusted weight among anemic children. Iron supplementation reduced the risk of anemia by 50% and the risk of iron deficiency by 79%. Adherence in the trial settings was generally high. Safety data were limited. Interpretation(s): Our analysis suggests that iron supplementation safely improves hematologic and nonhematologic outcomes among primary-school-aged children in low- or middleincome settings and is well-tolerated. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Canadian Medical Association (1867 Alta Vista Drive, Ottawa KIG5W8, Canada) | en |
dc.title | Effects of daily iron supplementation in primary-school-aged children: Systematic review and meta-analysis of randomized controlled trials. | en |
dc.type | Article | en |
dc.type.studyortrial | Systematic review and/or meta-analysis | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1503/cmaj.130628 | en |
dc.publisher.place | Canada | en |
dc.identifier.pubmedid | 24130243 [http://www.ncbi.nlm.nih.gov/pubmed/?term=24130243] | en |
dc.identifier.source | 370338140 | en |
dc.identifier.institution | (Low) Department of Clinical Haematology, Alfred Hospital, Prahran, Australia (Farrell, Pasricha) Thalassaemia Service, Southern Health, Clayton, United States (Biggs, Pasricha) Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Carlton, Australia (Pasricha) Nossal Institute for Global Health, Faculty of Medicine, University of Melbourne, Carlton, VIC, Australia | en |
dc.description.address | S.-R. Pasricha, Thalassaemia Service, Southern Health, Clayton, United States. E-mail: sant-rayn.pasricha@unimelb.edu.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2013 Elsevier B.V., All rights reserved. | en |
dc.identifier.authoremail | Pasricha S.-R.; sant-rayn.pasricha@unimelb.edu.au | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairetype | Article | - |
crisitem.author.dept | Haematology | - |
Appears in Collections: | Articles |
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