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DC Field | Value | Language |
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dc.contributor.author | Crawford N.W. | en |
dc.contributor.author | Kirkwood C.D. | en |
dc.contributor.author | Bishop R.F. | en |
dc.contributor.author | Lyon M. | en |
dc.contributor.author | Buttery J.P. | en |
dc.contributor.author | Donato C.M. | en |
dc.contributor.author | Ch'Ng L.S. | en |
dc.contributor.author | Boniface K.F. | en |
dc.date.accessioned | 2021-05-14T09:29:32Z | en |
dc.date.available | 2021-05-14T09:29:32Z | en |
dc.date.copyright | 2012 | en |
dc.date.created | 20120809 | en |
dc.date.issued | 2012-08-09 | en |
dc.identifier.citation | Journal of Infectious Diseases. 206 (3) (pp 377-383), 2012. Date of Publication: 01 Aug 2012. | en |
dc.identifier.issn | 0022-1899 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/28187 | en |
dc.description.abstract | Background. RotaTeq vaccine was introduced into the Australian National Immunisation Program in 2007. This study identified and characterised rotavirus strains excreted by infants who presented with symptoms of gastroenteritis following recent RotaTeq vaccination. Methods. Fecal samples (N = 61) from children who developed gastroenteritis following recent RotaTeq vaccination were forwarded to the Australian Rotavirus Surveillance Program (ARSP). RotaTeq-positive samples were genotyped and regions of the VP3, VP4, VP6, and VP7 genes were sequenced. Also, 460 rotavirus-positive ARSP routine surveillance samples were analyzed by dot-blot Northern hybridization to detect RotaTeq vaccine-derived strains circulating in the community. Results. Thirteen of the 61 samples collected from infants developing gastroenteritis after RotaTeq vaccination contained vaccine-derived (vd) rotavirus strains. Of these, 4 contained a vdG1P[8] strain derived by reassortment between the G1P[5] and G6P[8] parental vaccine strains. Northern hybridization analysis of 460 surveillance samples identified 3 samples that contained RotaTeq vaccine-derived strains, including 2 vdG1P[8] reassortant vaccine strains. Conclusions. During replication and excretion of RotaTeq vaccine, reassortment of parental strains can occur. Shedding of RotaTeq vaccine strains in 7 of 13 infants was associated with underlying medical conditions that may have altered their immune function. The benefits of vaccination outweigh any small risk of vaccine-associated gastroenteritis. © 2012 The Author. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Oxford University Press (Great Clarendon Street, Oxford OX2 6DP, United Kingdom) | en |
dc.title | Identification of strains of rotateq rotavirus vaccine in infants with gastroenteritis following routine vaccination. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1093/infdis/jis361 | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 22615314 [http://www.ncbi.nlm.nih.gov/pubmed/?term=22615314] | en |
dc.identifier.source | 365259684 | en |
dc.identifier.institution | (Donato, Ch'Ng, Boniface, Bishop, Kirkwood) Enteric Virus Group, Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia (Donato, Kirkwood) Department of Microbiology, La Trobe University, Bundoora, Australia (Ch'Ng, Crawford, Bishop) Department of Paediatrics, University of Melbourne, Australia (Crawford, Buttery) Department of General Medicine, Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia (Buttery) Department of Paediatrics, Monash Children's Hospital, Monash University, Melbourne, Australia (Lyon) Public Health Virology Laboratory, Forensic and Scientific Services, Queensland Health, Flemington Road, Parkville, VIC 3052, Australia | en |
dc.description.address | C.M. Donato, Enteric Virus Group, Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia. E-mail: cmdonato@students.latrobe.edu.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2013 Elsevier B.V., All rights reserved. | en |
dc.identifier.authoremail | Donato C.M.; cmdonato@students.latrobe.edu.au | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairetype | Article | - |
Appears in Collections: | Articles |
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