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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mulley W. | en |
dc.contributor.author | Ford S. | en |
dc.contributor.author | Summers S. | en |
dc.contributor.author | Cantwell L. | en |
dc.date.accessioned | 2021-05-14T09:30:01Z | en |
dc.date.available | 2021-05-14T09:30:01Z | en |
dc.date.copyright | 2012 | en |
dc.date.created | 20120426 | en |
dc.date.issued | 2012-04-26 | en |
dc.identifier.citation | Nephrology. 17 (SUPPL. 1) (pp 9-11), 2012. Date of Publication: April 2012. | en |
dc.identifier.issn | 1320-5358 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/28209 | en |
dc.description.abstract | Highly sensitised patients are at increased risk for antibody mediated rejection (AMR) and reduced graft survival. Highly sensitive assays for detecting recipient preformed anti-HLA antibodies have been developed and identify high immunological risk donors. A 62yo male with end stage renal failure secondary to glomerulonephritis received a T-cell crossmatch negative, deceased donor, renal transplant mismatched at 3 of 6 HLA loci. A donor specific antibody (DSAb) to DR17 (MFI 2073) was present. Given his advancing age, multiple medical comorbidities and broad HLA sensitisation the transplant was accepted, however, shortly before transplantation two atypical results were made available. Firstly a B-cell crossmatch was performed and found to be negative in current serum but strongly positive in peak serum, secondly a further potential DSAb was predicted based on linkage disequilibrium with known donor HLA typing. The donor HLA typing would not be clarified until after the transplant. Despite the increased risk of AMR the transplant proceeded with pre-emptive plasma exchange. The patient developed severe AMR requiring extensive therapy. Incomplete prospective donor HLA typing can generate uncertainty in the interpretation of the virtual crossmatch performed for deceased donor transplants. This may result in clinically relevant sequelae. Advances in antibody detection techniques need to be matched by timely donor HLA typing for its full benefit to be realised. © 2012 The Authors Nephrology © 2012 Asian Pacific Society of Nephrology. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Blackwell Publishing (550 Swanston Street, Carlton South VIC 3053, Australia) | en |
dc.title | Hidden perils in a highly sensitized kidney transplant recipient. | en |
dc.type | Article | en |
dc.type.studyortrial | Case series or case report | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/j.1440-1797.2012.01584.x | en |
dc.publisher.place | Australia | en |
dc.identifier.pubmedid | 22497647 [http://www.ncbi.nlm.nih.gov/pubmed/?term=22497647] | en |
dc.identifier.source | 364635667 | en |
dc.identifier.institution | (Ford, Summers, Mulley) Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia (Summers, Mulley) Department of Medicine, Monash University, Clayton, VIC, Australia (Cantwell) Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, South Melbourne, VIC, Australia | en |
dc.description.address | S. Ford, Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia. E-mail: sharon.ford@southernhealth.org.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2012 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Antibody mediated rejection Crossmatch Donor specific antibodies Human leukocyte antigen typing | en |
dc.identifier.authoremail | Ford S.; sharon.ford@southernhealth.org.au | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Nephrology | - |
Appears in Collections: | Articles |
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