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DC Field | Value | Language |
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dc.contributor.author | Foo S.E. | en |
dc.contributor.author | Polkinghorne K. | en |
dc.contributor.author | Uhe M. | en |
dc.contributor.author | Kerr P.G. | en |
dc.contributor.author | Sin H.K. | en |
dc.contributor.author | Kameshwar K. | en |
dc.contributor.author | Damasiewicz M. | en |
dc.date.accessioned | 2021-05-14T09:38:07Z | en |
dc.date.available | 2021-05-14T09:38:07Z | en |
dc.date.copyright | 2020 | en |
dc.date.created | 20210119 | en |
dc.date.issued | 2021-01-19 | en |
dc.identifier.citation | Nephrology. Conference: 55th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, ANZSN 2020. Virtual. 25 (SUPPL 3) (pp 34), 2020. Date of Publication: December 2020. | en |
dc.identifier.issn | 1440-1797 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/28605 | en |
dc.description.abstract | Aim: To compare properties of a novel asymmetrical cellulose triacetate (ATA) dialyser (Solacia 190-H, Nipro) to a commonly used high-flux polysulfone dialyser (FX-80, Fresenius) in patients undergoing long-hour (>7 hours) haemodialysis (HD). Background(s): The ATA membrane is highly porous and less prone to performance degradation, compared to a conventional high-flux membrane, potentially resulting in enhanced clearance of middle and large-middle molecules, along with protein bound solutes. Method(s): 10 long-hour home HD patients were included in this randomized cross-over trial. Patients were randomized to 4 weeks of either the 190-H or FX-80 dialyser with subsequent cross-over to the other. The removal of small (urea, phosphate and creatinine), middle and large-middle molecules (beta-2 microglobulin [B2M], indoxyl sulfate [IS], albumin) and markers of inflammation (interleukin-6 [IL-6], malondialdehyde-modified low density lipoprotein [MDA-LDL]), were evaluated during the mid-week dialysis session of the fourth week of each dialyser sequence. All results are expressed as mean differences in corresponding reduction ratios (RR) between the FX-80 and 190-H dialysers after 8 hours of dialysis. Result(s): There was no significant difference in reduction in clearance of small molecules, with a RR difference for urea -2.43 (p = 0.19), creatinine -1.82 (p = 0.28) and phosphate -2.61 (p = 0.55). Similarly, there was no difference in clearance of middle and large-middle molecules with a RR difference for B2M 2.63 (p = 0.22), IS 2.48 (p = 0.69) and albumin -0.15 (p = 0.96). There was also no difference in expression of inflammatory markers with RR for IL-6 18.8 (p = 0.44) and MDA-LDL -8.0 (p = 0.3). Conclusion(s): Our study did not demonstrate a difference in clearance of small, middle and large-middle molecules, nor the expression of markers of inflammation between the FX-80 and H-190 dialysers. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Blackwell Publishing | en |
dc.title | The efficiency of a novel asymmetrical cellulose triacetate dialysis membrane compared to a standard high-flux dialysis membrane; a pilot study. | en |
dc.type | Conference Abstract | en |
dc.identifier.affiliation | Nephrology | en |
dc.type.studyortrial | Randomised controlled trial | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url= | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/nep.13798 | en |
local.date.conferencestart | 2020-11-28 | en |
dc.identifier.source | 633927849 | en |
dc.identifier.institution | (Kameshwar, Damasiewicz, Polkinghorne, Foo, Uhe, Sin, Kerr) Department of Nephrology, Monash Health (Damasiewicz, Polkinghorne, Kerr) Department of Medicine, Monash University (Sin) Department of Nephrology, Kwong Was Hospital | en |
dc.description.address | K. Kameshwar, Department of Nephrology, Monash Health | en |
dc.description.publicationstatus | CONFERENCE ABSTRACT | en |
local.date.conferenceend | 2020-12-02 | en |
dc.rights.statement | Copyright 2021 Elsevier B.V., All rights reserved. | en |
dc.identifier.affiliationext | (Damasiewicz, Polkinghorne, Kerr) Department of Medicine, Monash University | - |
dc.identifier.affiliationext | (Sin) Department of Nephrology, Kwong Was Hospital | - |
dc.identifier.affiliationmh | (Kameshwar, Damasiewicz, Polkinghorne, Foo, Uhe, Sin, Kerr) Department of Nephrology, Monash Health | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairetype | Conference Abstract | - |
crisitem.author.dept | Nephrology | - |
crisitem.author.dept | Nephrology | - |
Appears in Collections: | Conferences |
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