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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Satsangi J. | en |
dc.contributor.author | Kalla R. | en |
dc.contributor.author | Borg-Bartolo S.P. | en |
dc.contributor.author | Boyapati R.K. | en |
dc.date.accessioned | 2021-05-14T09:43:47Z | en |
dc.date.available | 2021-05-14T09:43:47Z | en |
dc.date.copyright | 2020 | en |
dc.date.created | 20200617 | en |
dc.date.issued | 2020-06-17 | en |
dc.identifier.citation | F1000Research. 9 (no pagination), 2020. Article Number: 54. Date of Publication: 2020. | en |
dc.identifier.issn | 2046-1402 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/28871 | en |
dc.description.abstract | Crohn's disease and ulcerative colitis are increasingly prevalent, relapsing and remitting inflammatory bowel diseases (IBDs) with variable disease courses and complications. Their aetiology remains unclear but current evidence shows an increasingly complex pathophysiology broadly centring on the genome, exposome, microbiome and immunome. Our increased understanding of disease pathogenesis is providing an ever-expanding arsenal of therapeutic options, but these can be expensive and patients can lose response or never respond to certain therapies. Therefore, there is now a growing need to personalise therapies on the basis of the underlying disease biology and a desire to shift our approach from 'reactive' management driven by disease complications to 'proactive' care with an aim to prevent disease sequelae. Precision medicine is the tailoring of medical treatment to the individual patient, encompassing a multitude of data-driven (and multi-omic) approaches to foster accurate clinical decision-making. In IBD, precision medicine would have significant benefits, enabling timely therapy that is both effective and appropriate for the individual. In this review, we summarise some of the key areas of progress towards precision medicine, including predicting disease susceptibility and its course, personalising therapies in IBD and monitoring response to therapy. We also highlight some of the challenges to be overcome in order to deliver this approach.Copyright © 2020 Borg-Bartolo SP et al. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | F1000 Research Ltd | en |
dc.relation.ispartof | F1000 Research | en |
dc.subject.mesh | patient care | - |
dc.subject.mesh | patient monitoring | - |
dc.subject.mesh | peer | - |
dc.subject.mesh | personalized medicine | - |
dc.subject.mesh | phenotype | - |
dc.subject.mesh | relapse | - |
dc.subject.mesh | remission | - |
dc.subject.mesh | ulcerative colitis | - |
dc.subject.mesh | tumor necrosis factor antibody | - |
dc.subject.mesh | clinical decision making | - |
dc.subject.mesh | conceptual framework | - |
dc.subject.mesh | Crohn disease | - |
dc.subject.mesh | disease marker | - |
dc.subject.mesh | disease predisposition | - |
dc.subject.mesh | dysbiosis | - |
dc.subject.mesh | environmental factor | - |
dc.subject.mesh | genetic risk | - |
dc.subject.mesh | immune response | - |
dc.subject.mesh | inflammatory bowel disease | - |
dc.subject.mesh | pathogenesis | - |
dc.subject.mesh | pathophysiology | - |
dc.title | Precision medicine in inflammatory bowel disease: Concept, progress and challenges. | en |
dc.type | Review | en |
dc.identifier.affiliation | Gastroenterology and Hepatology | - |
dc.type.studyortrial | Review article (e.g. literature review, narrative review) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.12688/f1000research.20928.1 | - |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 32047622 [http://www.ncbi.nlm.nih.gov/pubmed/?term=32047622] | en |
dc.identifier.source | 631886607 | en |
dc.identifier.institution | (Borg-Bartolo) Department of Gastroenterology, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Wythenshawe, Manchester M23 9LT, United Kingdom (Boyapati) Department of Gastroenterology, Monash Health, Clayton, VIC, Australia (Boyapati) Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia (Satsangi) Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (Kalla) Department of Gastroenterology, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, United Kingdom | en |
dc.description.address | R. Kalla, Department of Gastroenterology, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, United Kingdom. E-mail: rahul.kalla@ed.ac.uk | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2020 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Biomarkers Crohn's disease Genomics Inflammatory bowel disease Microbiome Precision medicine Prognosis Therapeutics Ulcerative colitis | en |
dc.identifier.authoremail | Kalla R.; rahul.kalla@ed.ac.uk | en |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | Review | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
Appears in Collections: | Articles |
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