Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/28977
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shehabi Y. | en |
dc.contributor.author | Ely E.W. | en |
dc.contributor.author | Slooter A.J.C. | en |
dc.contributor.author | MacLullich A.M.J. | en |
dc.contributor.author | Cunningham C. | en |
dc.contributor.author | Girard T.D. | en |
dc.contributor.author | Wilson J.E. | en |
dc.contributor.author | Mart M.F. | en |
dc.date.accessioned | 2021-05-14T09:46:18Z | en |
dc.date.available | 2021-05-14T09:46:18Z | en |
dc.date.copyright | 2020 | en |
dc.date.created | 20201224 | en |
dc.date.issued | 2020-12-24 | en |
dc.identifier.citation | Nature Reviews Disease Primers. 6 (1) (no pagination), 2020. Article Number: 90. Date of Publication: December 2020. | en |
dc.identifier.issn | 2056-676X (electronic) | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/28977 | en |
dc.description.abstract | Delirium, a syndrome characterized by an acute change in attention, awareness and cognition, is caused by a medical condition that cannot be better explained by a pre-existing neurocognitive disorder. Multiple predisposing factors (for example, pre-existing cognitive impairment) and precipitating factors (for example, urinary tract infection) for delirium have been described, with most patients having both types. Because multiple factors are implicated in the aetiology of delirium, there are likely several neurobiological processes that contribute to delirium pathogenesis, including neuroinflammation, brain vascular dysfunction, altered brain metabolism, neurotransmitter imbalance and impaired neuronal network connectivity. The Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) is the most commonly used diagnostic system upon which a reference standard diagnosis is made, although many other delirium screening tools have been developed given the impracticality of using the DSM-5 in many settings. Pharmacological treatments for delirium (such as antipsychotic drugs) are not effective, reflecting substantial gaps in our understanding of its pathophysiology. Currently, the best management strategies are multidomain interventions that focus on treating precipitating conditions, medication review, managing distress, mitigating complications and maintaining engagement to environmental issues. The effective implementation of delirium detection, treatment and prevention strategies remains a major challenge for health-care organizations globally.Copyright © 2020, Springer Nature Limited. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Nature Research | en |
dc.relation.ispartof | Nature Reviews Disease Primers | - |
dc.title | Delirium. | en |
dc.type | Review | en |
dc.type.studyortrial | Review article (e.g. literature review, narrative review) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41572-020-00223-4 | - |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 33184265 [http://www.ncbi.nlm.nih.gov/pubmed/?term=33184265] | en |
dc.identifier.source | 2007254320 | en |
dc.identifier.institution | (Wilson, Mart, Girard, Ely) Center for Critical Illness, Brain Dysfunction, and Survivorship (CIBS), Vanderbilt University Medical Center, Nashville, TN, United States (Wilson) Department of Psychiatry and Behavioral Sciences, Division of General Psychiatry, Vanderbilt University Medical Center, Nashville, TN, United States (Mart, Ely) Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States (Cunningham) School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland (Shehabi) Monash Health School of Clinical Sciences, Monash University, Melbourne, VIC, Australia (Shehabi) Prince of Wales Clinical School of Medicine, University of New South Wales, Sydney, NSW, Australia (Girard) Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States (MacLullich) Edinburgh Delirium Research Group, Geriatric Medicine, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom (Slooter) Department of Intensive Care Medicine and UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (Ely) Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, United States (Ely) Veteran's Affairs TN Valley, Geriatrics Research, Education and Clinical Center (GRECC), Nashville, TN, United States | en |
dc.description.address | J.E. Wilson, Center for Critical Illness, Brain Dysfunction, and Survivorship (CIBS), Vanderbilt University Medical Center, Nashville, TN, United States. E-mail: jo.e.wilson@vumc.org | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2020 Elsevier B.V., All rights reserved. | en |
dc.identifier.authoremail | Wilson J.E.; jo.e.wilson@vumc.org | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Review | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Monash University - School of Clinical Sciences at Monash Health | - |
Appears in Collections: | Articles |
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.