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DC Field | Value | Language |
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dc.contributor.author | Fuller P.J. | en |
dc.contributor.author | Yang J. | en |
dc.contributor.author | Solanki P. | en |
dc.contributor.author | Gwini S.M. | en |
dc.contributor.author | Doery J.C.G. | en |
dc.contributor.author | Choy K.W. | en |
dc.contributor.author | Shen J. | en |
dc.contributor.author | Young M.J. | en |
dc.date.accessioned | 2021-05-14T09:51:34Z | en |
dc.date.available | 2021-05-14T09:51:34Z | en |
dc.date.copyright | 2020 | en |
dc.date.created | 20200827 | en |
dc.date.issued | 2020-08-27 | en |
dc.identifier.citation | Clinical Endocrinology. 93 (3) (pp 221-228), 2020. Date of Publication: 01 Sep 2020. | en |
dc.identifier.issn | 0300-0664 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/29203 | en |
dc.description.abstract | Objective: Current Endocrine Society Clinical Practice Guidelines use a specific aldosterone/renin ratio (ARR) threshold to screen for primary aldosteronism (a treatable disease causing up to 15% of hypertension in primary care) in all patients. We sought to characterize demographic variations in the ARR, hypothesizing a need for age- and sex-specific reference ranges to improve the accuracy of the test. Design(s): Retrospective cross-sectional analysis of ARR measurements at a single tertiary hospital from December 2016 to June 2018. Patient(s): A total of 442 patients with clinically indicated ARR were included, after excluding those who were on spironolactone or the oral contraceptive pill, were pregnant or had an existing adrenal condition. Measurements: Aldosterone, renin and the ARR. Result(s): Among those aged 20-39 years (n = 74), females had significantly higher median aldosterone (369 vs 244 pmol/L, P =.028), lower median renin (17.0 vs 27.6 mIU/L, P =.034) and higher median ARR (20.7 vs 10.3 (pmol/L)/(mIU/L), P =.001) than males, despite having lower systolic (135 vs 145 mmHg, P =.021) and diastolic (89 vs 96.5 mmHg, P =.007) blood pressure. The >= 60-year age group (n = 157) also had significant sex differences in the ARR. With increasing age (20-39 vs >= 60 years), there was a significant fall in plasma aldosterone in females (369 pmol/L vs 264 pmol/L, P =.005), with no change observed in males. Conclusion(s): For those 20-39 years old, aldosterone and the ARR are significantly higher in females despite a lower systolic and diastolic BP, highlighting the potential for false-positive results. Our findings indicate the need for prospective studies with a control population to define age- and sex-specific ARR reference ranges.Copyright © 2020 John Wiley & Sons Ltd | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Blackwell Publishing Ltd | en |
dc.relation.ispartof | Clinical Endocrinology | en |
dc.subject.mesh | alpha 1 adrenergic receptor blocking agent | - |
dc.subject.mesh | angiotensin receptor antagonist | - |
dc.subject.mesh | antihypertensive agent | - |
dc.subject.mesh | beta adrenergic receptor blocking agent | - |
dc.subject.mesh | calcium channel blocking agent | - |
dc.subject.mesh | dihydropyridine | - |
dc.subject.mesh | dipeptidyl carboxypeptidase inhibitor | - |
dc.subject.mesh | diuretic agent | - |
dc.subject.mesh | nitrate | - |
dc.subject.mesh | renin | - |
dc.subject.mesh | aldosterone renin ratio | - |
dc.subject.mesh | aldosterone blood level | - |
dc.subject.mesh | concentration ratio | - |
dc.subject.mesh | diastolic blood pressure | - |
dc.subject.mesh | false positive result | - |
dc.subject.mesh | hypertension | - |
dc.subject.mesh | reference value | - |
dc.subject.mesh | sex difference | - |
dc.subject.mesh | sex ratio | - |
dc.subject.mesh | systolic blood pressure | - |
dc.subject.mesh | tertiary care center | - |
dc.subject.mesh | aldosterone | - |
dc.title | Age- and sex-specific reference ranges are needed for the aldosterone/renin ratio. | en |
dc.type | Article | en |
dc.identifier.affiliation | Endocrinology | - |
dc.type.studyortrial | Observational study (cohort, case-control, cross sectional or survey) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/cen.14199 | - |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 32306417 [http://www.ncbi.nlm.nih.gov/pubmed/?term=32306417] | en |
dc.identifier.source | 2004813909 | en |
dc.identifier.institution | (Solanki, Choy, Shen, Fuller, Yang) Department of Endocrinology, Monash Health, Clayton, Vic., Australia (Solanki, Doery, Yang) Department of Medicine, Monash University, Clayton, Vic., Australia (Gwini) Barwon Health, University Hospital Geelong, Geelong, Vic., Australia (Gwini) School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia (Shen, Young, Fuller, Yang) Hudson Institute of Medical Research, Clayton, Vic., Australia | en |
dc.description.address | P. Solanki, Department of Endocrinology, Monash Health, Clayton, Vic., Australia. E-mail: pravik.solanki@gmail.com P. Solanki, Department of Medicine, Monash University, Clayton, Vic., Australia. E-mail: pravik.solanki@gmail.com | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2020 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | age aldosterone diagnostic techniques endocrine hyperaldosteronism hypertension renin sex | en |
dc.identifier.authoremail | Solanki P.; pravik.solanki@gmail.com | en |
dc.description.grant | Organization: (ESA) *Endocrine Society of Australia* Organization No: 501100001114 Country: Australia Organization: (HBPRCA) *High Blood Pressure Research Council of Australia* Organization No: 501100001201 Country: Australia Organization: *Hudson Institute* Organization No: 100005890 Country: United States No: 101863 Organization: *National Heart Foundation of Australia* Organization No: 501100001030 Country: Australia No: 7967 Organization: *Cass Foundation* Organization No: 501100001043 Country: Australia | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Endocrinology | - |
crisitem.author.dept | Pathology | - |
Appears in Collections: | Articles |
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