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DC Field | Value | Language |
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dc.contributor.author | Sypek M.P. | en |
dc.contributor.author | Cantwell L. | en |
dc.contributor.author | Hiho S. | en |
dc.contributor.author | Clayton P. | en |
dc.contributor.author | Hughes P. | en |
dc.contributor.author | Le Page A.K. | en |
dc.contributor.author | Kausman J. | en |
dc.date.accessioned | 2021-05-14T09:53:17Z | en |
dc.date.available | 2021-05-14T09:53:17Z | en |
dc.date.copyright | 2020 | en |
dc.date.created | 20200604 | en |
dc.date.issued | 2020-06-04 | en |
dc.identifier.citation | Pediatric Transplantation. 24 (4) (no pagination), 2020. Article Number: e13705. Date of Publication: 01 Jun 2020. | en |
dc.identifier.issn | 1397-3142 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/29277 | en |
dc.description.abstract | Background: HLA epitope-based matching offers the potential to improve immunological risk prediction and management in children receiving renal allografts; however, studies demonstrating the association between systems for defining epitope mismatches and clinical end-points are lacking in this population. Method(s): We conducted a pragmatic, retrospective, registry-based study of pediatric recipients of primary renal allografts in Victoria, Australia between 1990 and 2014 to determine the association between HLA EpMM and clinical outcomes including graft failure, re-transplantation and dnDSA formation. Result(s): A total of 196 patients were included in the analysis with a median age of 11 years. Median follow-up period was 15 years during which time 108 (55%) primary grafts failed and 72 patients were re-transplanted. HLA class I but not class II EpMM was a significant predictor of graft failure on univariate analysis but not in adjusted models. EpMM was associated with reduced likelihood of re-transplantation in univariate but not adjusted analysis. Within the limitations of the study, class-specific EpMM was a strong predictor of dnDSA formation. Associations were stronger when considering only the subset of antibody-verified EpMM. Conclusion(s): Associations between HLA EpMM and clinical outcomes in pediatric renal allograft recipients seen on univariate analysis were attenuated following adjustment for confounders. These findings are inconclusive but suggest that HLA EpMM may provide one tool for assessing long-term risk in this population while highlighting the need for further clinical studies.Copyright © 2020 Wiley Periodicals LLC | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Blackwell Publishing Inc. (E-mail: subscrip@blackwellpub.com) | en |
dc.relation.ispartof | Pediatric Transplantation | en |
dc.subject.mesh | Victoria | - |
dc.subject.mesh | epitope | - |
dc.subject.mesh | HLA antigen class 1 | - |
dc.subject.mesh | leukocyte antigen | - |
dc.subject.mesh | kidney allograft | - |
dc.subject.mesh | graft failure/co | - |
dc.subject.mesh | graft survival | - |
dc.subject.mesh | HLA system | - |
dc.subject.mesh | pediatric surgery | - |
dc.subject.mesh | pragmatic trial | - |
dc.subject.mesh | retransplantation | - |
dc.subject.mesh | school child | - |
dc.title | Human leukocyte antigen eplet mismatches and long-term clinical outcomes in pediatric renal transplantation: A pragmatic, registry-based study. | en |
dc.type | Article | en |
dc.identifier.affiliation | Paediatric - Nephrology | - |
dc.type.studyortrial | Observational study (cohort, case-control, cross sectional or survey) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/petr.13705 | - |
dc.publisher.place | United States | en |
dc.identifier.pubmedid | 32319719 [http://www.ncbi.nlm.nih.gov/pubmed/?term=32319719] | en |
dc.identifier.source | 2004724172 | en |
dc.identifier.institution | (Sypek, Hughes) Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, Australia (Sypek, Kausman) Department of Nephrology, Royal Children's Hospital, Melbourne, VIC, Australia (Sypek, Hughes) Department of Nephrology, Royal Melbourne Hospital, Melbourne, VIC, Australia (Sypek, Clayton) Australia and New Zealand Dialysis and Transplant Registry, Adelaide, SA, Australia (Hiho, Cantwell) Australian Red Cross Blood Service, Melbourne, VIC, Australia (Clayton) Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia (Clayton) Central and Northern Renal and Transplant Services, Central Adelaide Local Health Network, Adelaide, SA, Australia (Le Page) Department of Nephrology, Monash Children's Hospital, Melbourne, VIC, Australia (Le Page) Department of Paediatrics, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia (Kausman) Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia (Kausman) Murdoch Children's Research Institute, Melbourne, VIC, Australia | en |
dc.description.address | M.P. Sypek, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, Australia. E-mail: matthew.sypek@rch.org.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2020 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | donor-specific antibodies epitope eplet graft survival human leukocyte antigen re-transplantation renal transplant | en |
dc.identifier.authoremail | Sypek M.P.; matthew.sypek@rch.org.au | en |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | Articles |
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