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Title: | Drug-mediated and cellular immunotherapy in multiple myeloma. | Authors: | Neeson P.;Ritchie D.S.;Quach H.;Fielding K. | Institution: | (Ritchie, Quach, Fielding, Neeson) Haematology and Immunology Translational Research Laboratory, Cancer Immunology Research Program, Locked Bag 1, ABeckett St, East Melbourne, VIC 8000, Australia (Ritchie) Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Locked Bag 1, ABeckett St, East Melbourne, VIC 8000, Australia (Ritchie) University of Melbourne, Parkville, VIC, Australia (Quach) Monash Medical Centre, Clayton, VIC, Australia | Issue Date: | 27-May-2010 | Copyright year: | 2010 | Publisher: | Future Medicine Ltd. (E-mail: info@futuremedicine.com) | Place of publication: | United Kingdom | Publication information: | Immunotherapy. 2 (2) (pp 243-255), 2010. Date of Publication: March 2010. | Journal: | Immunotherapy | Abstract: | Multiple myeloma is an immunologically relevant disease, which subverts and suppresses immunity, but that may also be amenable to immunological control. Novel drug and cell-based therapies provide an opportunity for the design of antimyeloma immunotherapy. Reversing the immunosuppression associated myeloma remains a substantial challenge. The minimal residual disease setting achieved by autologous stem cell transplant or highly efficacious induction therapy may reverse this immunoparesis and provide a setting for induction of antimyeloma T-cell responses. Adoptive cytotoxic T-lymphocyte/NK therapy and comprehensive treatment with immunomodulatory drug therapy represent means by which antimyeloma immune responses may be promoted. In addition, apoptosis-inducing therapies may prime endogenous antigen presentation via immunogenic cell death, which again may be enhanced by the addition of immunomodulatory drug therapy. © 2010 Future Medicine Ltd. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.2217/imt.10.9 | PubMed URL: | 20635931 [http://www.ncbi.nlm.nih.gov/pubmed/?term=20635931] | ISSN: | 1750-743X | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/30446 | Type: | Review | Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
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