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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ma F.Y. | en |
dc.contributor.author | Nikolic-Paterson D.J. | en |
dc.contributor.author | Ikezumi Y. | en |
dc.date.accessioned | 2021-05-14T10:28:28Z | en |
dc.date.available | 2021-05-14T10:28:28Z | en |
dc.date.copyright | 2010 | en |
dc.date.created | 20100705 | en |
dc.date.issued | 2012-10-12 | en |
dc.identifier.citation | Seminars in Nephrology. 30 (3) (pp 334-344), 2010. Date of Publication: May 2010. | en |
dc.identifier.issn | 0270-9295 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/30973 | en |
dc.description.abstract | Monocytes/macrophages are a heterogeneous cell population that play a critical role in host defense and tissue homeostasis. However, macrophage activation during acute and chronic inflammation can result in macrophage-mediated renal injury in a variety of settings, including proliferative glomerulonephritis. Macrophages can be activated via a number of intracellular signaling pathways (eg, c-Jun amino terminal kinase, p38 mitogen-activated protein kinase, FcR/Syk, Janus kinase/signal transducer and activator of transcription) that induce production of mediators of renal injury. Thus, targeting selected macrophage signaling pathways is a potential therapeutic strategy to suppress macrophage-mediated renal injury while leaving intact the desirable macrophage functions of host defense and tissue repair. © 2010 Elsevier Inc. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | W.B. Saunders (Independence Square West, Philadelphia PA 19106-3399, United States) | en |
dc.title | Macrophage signaling pathways: A novel target in renal disease. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.semnephrol.2010.03.008 | en |
dc.publisher.place | United States | en |
dc.identifier.pubmedid | 20620676 [http://www.ncbi.nlm.nih.gov/pubmed/?term=20620676] | en |
dc.identifier.source | 359061178 | en |
dc.identifier.institution | (Ma, Nikolic-Paterson) Department of Nephrology and Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia (Ikezumi) Department of Pediatrics, Niigata University Medical and Dental Hospital, Niigata, Japan | en |
dc.description.address | D.J. Nikolic-Paterson, Department of Nephrology, Monash Medical Centre, Clayton Rd, Clayton, VIC 3168, Australia. E-mail: david.nikolic-paterson@med.monash.edu.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2012 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | C-fms JNK NFkB P38 MAPK | en |
dc.identifier.authoremail | Nikolic-Paterson D.J.; david.nikolic-paterson@med.monash.edu.au | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Nephrology | - |
Appears in Collections: | Articles |
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