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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Holdsworth S.R. | en |
dc.contributor.author | Summers S.A. | en |
dc.contributor.author | Steinmetz O.M. | en |
dc.contributor.author | Li M. | en |
dc.contributor.author | Kausman J.Y. | en |
dc.contributor.author | Semple T. | en |
dc.contributor.author | Edgtton K.L. | en |
dc.contributor.author | Borza D.-B. | en |
dc.contributor.author | Braley H. | en |
dc.contributor.author | Kitching A.R. | en |
dc.date.accessioned | 2021-05-14T10:33:41Z | en |
dc.date.available | 2021-05-14T10:33:41Z | en |
dc.date.copyright | 2009 | en |
dc.date.created | 20100108 | en |
dc.date.issued | 2012-10-15 | en |
dc.identifier.citation | Journal of the American Society of Nephrology. 20 (12) (pp 2518-2524), 2009. Date of Publication: 01 Dec 2009. | en |
dc.identifier.issn | 1046-6673 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/31222 | en |
dc.description.abstract | Th1 effector CD4+ cells contribute to the pathogenesis of proliferative and crescentic glomerulonephritis, but whether effector Th17 cells also contribute is unknown. We compared the involvement of Th1 and Th17 cells in a mouse model of antigen-specific glomerulonephritis in which effector CD4+ cells are the only components of adaptive immunity that induce injury. We planted the antigen ovalbumin on the glomerular basement membrane of Rag1-/- mice using an ovalbumin-conjugated non-nephritogenic IgG1 monoclonal antibody against alpha3(IV) collagen. Subsequent injection of either Th1- or Th17-polarized ovalbumin-specific CD4+ effector cells induced proliferative glomerulonephritis. Mice injected with Th1 cells developed progressive albuminuria over 21 d, histologic injury including 5.5 +/- 0.9% crescent formation/segmental necrosis, elevated urinary nitrate, and increased renal NOS2, CCL2, and CCL5 mRNA. Mice injected with Th17 cells developed albuminuria by 3 d; compared with Th1-injected mice, their glomeruli contained more neutrophils and greater expression of renal CXCL1 mRNA. In conclusion, Th1 and Th17 effector cells can induce glomerular injury. Understanding how these two subsets mediate proliferative forms of glomerulonephritis may lead to targeted therapies. Copyright © 2009 by the American Society of Nephrology. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | American Society of Nephrology (1725 I Street NW, Suite 510, Washington DC 20006, United States) | en |
dc.title | Th1 and Th17 cells induce proliferative glomerulonephritis. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1681/ASN.2009030337 | en |
dc.publisher.place | United States | en |
dc.identifier.pubmedid | 19820122 [http://www.ncbi.nlm.nih.gov/pubmed/?term=19820122] | en |
dc.identifier.source | 355791404 | en |
dc.identifier.institution | (Summers, Steinmetz, Li, Kausman, Semple, Edgtton, Holdsworth, Kitching) Centre for Inflammatory Diseases, Monash University, Department of Medicine, 246 Clayton Road, Clayton, VIC 3168, Australia (Borza) Departments of Medicine and Pathology, Vanderbilt University School of Medicine, Nashville, TN, United States (Braley) CSL Limited, Parkville, VIC, Australia (Holdsworth, Kitching) Department of Nephrology, Monash Medical Centre, VIC, Australia | en |
dc.description.address | A. R. Kitching, Centre for Inflammatory Diseases, Monash University, Department of Medicine, 246 Clayton Road, Clayton, VIC 3168, Australia. E-mail: richard.kitching@med.monash.edu.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2012 Elsevier B.V., All rights reserved. | en |
dc.identifier.authoremail | Kitching A.R.; richard.kitching@med.monash.edu.au | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Immunology and Allergy | - |
crisitem.author.dept | Nephrology | - |
Appears in Collections: | Articles |
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