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dc.contributor.authorBrown J.J.en
dc.contributor.authorZacharin M.R.en
dc.contributor.authorRamalingam L.en
dc.date.accessioned2021-05-14T10:42:09Zen
dc.date.available2021-05-14T10:42:09Zen
dc.date.copyright2008en
dc.date.created20080613en
dc.date.issued2012-10-16en
dc.identifier.citationClinical Endocrinology. 68 (6) (pp 863-867), 2008. Date of Publication: June 2008.en
dc.identifier.issn0300-0664en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/31627en
dc.description.abstractBackground: Bisphosphonate use in adult patients has been linked to osteonecrosis of the jaw (ONJ). This complication has not been systematically assessed in a paediatric population receiving bisphosphonates. Objective(s): To assess our cohort of paediatric patients treated with intravenous bisphosphonate for occurrence of ONJ. Design(s): Observational study at a tertiary children's hospital. Patient(s): A total of 42 paediatric patients with osteoporosis who received bisphosphonate infusions for a mean of 6.5 years (SD 2.7 years) were assessed clinically and radiographically for possible ONJ. Among 42, 37 patients had received disodium pamidronate 1 mg/kg/dose at a mean cumulative dose of 19.8 mg/kg and zoledronic acid (ZA) 0.05 mg/kg/dose at a mean cumulative dose of 0.49 mg/kg; four had received ZA and one received pamidronate alone. Invasive dental treatment during bisphosphonate treatment, a known risk factor for osteonecrosis, was specifically assessed. Result(s): In all patients assessed, including 11 who had invasive dental treatment, there were no cases of osteonecrosis. Conclusion(s): ONJ has so far not been demonstrated in this patient group. © 2008 The Authors.en
dc.languageenen
dc.languageEnglishen
dc.publisherBlackwell Publishing Ltd (9600 Garsington Road, Oxford OX4 2XG, United Kingdom)en
dc.titleBisphosphonate-associated osteonecrosis of the jaw: Does it occur in children?.en
dc.typeArticleen
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/j.1365-2265.2008.03189.xen
dc.publisher.placeUnited Kingdomen
dc.identifier.pubmedid18221397 [http://www.ncbi.nlm.nih.gov/pubmed/?term=18221397]en
dc.identifier.source351703958en
dc.identifier.institution(Brown) Monash Medical Centre, Clayton, VIC 3168, Australia (Brown, Zacharin) Department of Endocrinology and Diabetes, Royal Children's Hospital, Parkville, VIC 3052, Australia (Ramalingam) Department of Dentistry, Royal Children's Hospital, Parkville, VIC 3052, Australia (Zacharin) Department of Endocrinology and Diabetes, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, Australiaen
dc.description.addressM. R. Zacharin, Department of Endocrinology and Diabetes, Royal Children's Hospital, Flemington Road, Parkville, VIC 3052, Australia. E-mail: margaret.zacharin@rch.org.auen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2012 Elsevier B.V., All rights reserved.en
dc.identifier.authoremailZacharin M.R.; margaret.zacharin@rch.org.auen
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeArticle-
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