Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/31781
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu V. | en |
dc.contributor.author | Tan J.-B. | en |
dc.date.accessioned | 2021-05-14T10:45:23Z | en |
dc.date.available | 2021-05-14T10:45:23Z | en |
dc.date.copyright | 2007 | en |
dc.date.created | 20071003 | en |
dc.date.issued | 2012-10-17 | en |
dc.identifier.citation | World Journal of Pediatrics. 3 (3) (pp 170-186), 2007. Date of Publication: August 2007. | en |
dc.identifier.issn | 1708-8569 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/31781 | en |
dc.description.abstract | Background: With advances in neonatal intensive care, increasing numbers of preterm neonates are now surviving. In the past they would have died before there was time to develop chronic lung disease (CLD). Based on the definition of a neonate requiring any form of respiratory therapy (oxygen or assisted ventilation) at 36 weeks' post-menstrual age, the CLD rate in Australia is 52% in those <28 weeks and 12% in those 28-32 weeks gestation. The high CLD rate in the former group is due to their improved survival rates (one-year survival rate of infants born in the State of Victoria is 41% at 23 and 24 weeks, 73% at 25 weeks, and 88% at 26 weeks). Data sources: Randomized controlled trials (RCTs), including meta-analyses and Cochrane reviews on the prevention and treatment of CLD were identified in the published literature. Result(s): The following perinatal strategies were found to be effective in preventing or minimizing CLD: antenatal corticosteroids, postnatal surfactant, reduced oxygen saturation targeting at 89%-94%, early use of continuous positive airway pressure, synchronized ventilation, permissive hypercapnia ventilation strategy, high frequency oscillatory ventilation, closure of symptomatic patent ductus arteriosus with indomethacin, reduced fluid intake, and inhaled nitric oxide. Several anti-inflammatory and anti-oxidant agents have been found in RCTs to be effective, including vitamin A and recombinant human superoxide dismutase. Clinical management after the development of CLD includes appropriate oxygen and ventilation strategies, fluid restriction, and diuretic and bronchodilator therapy. Postnatal corticosteroid therapy is efficacious but its side-effect is increasing. The risk of cerebral palsy outweighs the benefit of therapy. Only in severe CLD, low-dose and short-course dexamethasone should be used. Conclusion(s): Ongoing basic and clinical research is required to identify perinatal and neonatal interventions that are effective in either preventing or treating CLD in preterm neonates. © 2007, World J Pediatr. All rights reserved. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Institute of Pediatrics of Zhejiang University (57 Zhugan Xiang, Hangzhou 310003, China) | en |
dc.title | Chronic lung disease in preterm neonates. | en |
dc.type | Article | en |
dc.type.studyortrial | Systematic review and/or meta-analysis | - |
dc.publisher.place | United States | en |
dc.identifier.source | 47288206 | en |
dc.identifier.institution | (Yu) Department of Pediatrics, Ritchie Centre for Baby Health Research, Monash University, 246 Clayton Road, Clayton, VIC 3168, Australia (Tan) Newborn Services, Monash Medical Centre, Clayton, VIC, Australia | en |
dc.description.address | V. Yu, Department of Paediatrics, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia. E-mail: victor.yu@med.monash.edu.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2012 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Bronchopulmonary dysplasia Chronic lung disease Neonatal intensive care Prematurity Respiratory failure | en |
dc.identifier.authoremail | Yu V.; victor.yu@med.monash.edu.au | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
Appears in Collections: | Articles |
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.