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Title: | The management of insulin resistance in polycystic ovary syndrome. | Authors: | Zoungas S.;Teede H.J. ;Hutchison S.K. | Institution: | (Teede, Hutchison, Zoungas) Jean Hailes Research Unit, Monash Institute, Health Services Research, Melbourne, Australia (Teede, Hutchison, Zoungas) Diabetes Unit, Southern Health, Melbourne, Australia | Issue Date: | 17-Oct-2012 | Copyright year: | 2007 | Publisher: | Elsevier Inc. (360 Park Avenue South, New York NY 10010, United States) | Place of publication: | United States | Publication information: | Trends in Endocrinology and Metabolism. 18 (7) (pp 273-279), 2007. Date of Publication: September 2007. | Abstract: | Polycystic ovary syndrome (PCOS) has reproductive and metabolic implications. Insulin resistance (IR), secondary to genetic and lifestyle factors, is integral in the pathogenesis, metabolic, clinical features and the long-term sequelae in the majority of people with PCOS. Therapeutic strategies targeting IR in PCOS ameliorate clinical features and might reduce long-term sequelae including diabetes. The mainstay for improving IR is lifestyle change; however, feasibility and sustainability remain concerns. In PCOS, metformin reduces IR, improves ovarian function, regulates cycles, lowers androgens, improves clinical hyperandrogenism and potentially improves fertility. Metformin is also likely to delay diabetes onset and has a role in PCOS in those at high risk of diabetes; however, further research is needed to clarify specific target subgroups and clinical indications. © 2007 Elsevier Ltd. All rights reserved. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.tem.2007.08.001 | PubMed URL: | 17698366 [http://www.ncbi.nlm.nih.gov/pubmed/?term=17698366] | ISSN: | 1043-2760 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/31793 | Type: | Review | Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
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