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DC Field | Value | Language |
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dc.contributor.author | Holdsworth S.R. | en |
dc.contributor.author | Kitching A.R. | en |
dc.contributor.author | Odobasic D. | en |
dc.contributor.author | Semple T.J. | en |
dc.date.accessioned | 2021-05-14T10:45:43Z | en |
dc.date.available | 2021-05-14T10:45:43Z | en |
dc.date.copyright | 2007 | en |
dc.date.created | 20070416 | en |
dc.date.issued | 2012-10-16 | en |
dc.identifier.citation | Journal of the American Society of Nephrology. 18 (3) (pp 760-770), 2007. Date of Publication: March 2007. | en |
dc.identifier.issn | 1046-6673 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/31795 | en |
dc.description.abstract | Myeloperoxidase (MPO) is an enzyme that is found in neutrophils and monocytes/macrophages. Intracellularly, it plays a major role in microbial killing, but extracellularly, it may cause host tissue damage. The role of endogenous MPO was studied during neuhophil-mediated (heterologous) and T helper 1 (Th1)/macrophage-mediated (autologous) phases of crescentic glomerulonephritis. Glomerulonephritis was induced in C57BL/6 wild-type (WT) and MPO-deficient (MPO-/-) mice by intravenous injection of sheep anti-mouse glomerular basement membrane globulin. MPO activity was increased in kidneys of WT mice during both the heterologous and autologous phases of glomerulonephritis. During the heterologous phase of glomerulonephritis, proteinuria was decreased, whereas glomerular neutrophil accumulation and F-selectin expression were enhanced in MPO-/- mice. In the autologous, crescentic phase of glomerulonephritis, MPO-/- mice had increased accumulation of CD4+ cells and macrophages in glomeruli compared with WT mice. However, no difference in renal injury (crescent formation, proteinuria, and serum creatinine levels) was observed. Neutrophils and macrophages from MPO-/- mice exhibited reduced production of reactive oxygen species. Assessment of systemic immunity to sheep globulin showed that MPO-/- mice had increased splenic CD4+ cell proliferation, cytokine production, and dermal delayed-type hypersensitivity, as well as enhanced levels of circulating IgG, IgG1, and IgG3. MPO-/- mice also had an augmented Th1:Th2 ratio compared with WT mice (IFN-gamma:IL-4 and IgG3:IgG1 ratios). These results suggest that endogenous MPO locally contributes to glomerular damage during neutrophil-mediated glomerulonephritis, whereas it attenuates initiation of the adaptive immune response inducing crescentic, autologous-phase glomerulonephritis by suppressing T cell proliferation, cytokine production, and Th1:Th2 ratio. Copyright © 2007 by the American Society of Nephrology. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | American Society of Nephrology (1725 I Street NW, Suite 510, Washington DC 20006, United States) | en |
dc.title | Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1681/ASN.2006040375 | en |
dc.publisher.place | United States | en |
dc.identifier.pubmedid | 17267745 [http://www.ncbi.nlm.nih.gov/pubmed/?term=17267745] | en |
dc.identifier.source | 46434493 | en |
dc.identifier.institution | (Odobasic, Kitching, Semple, Holdsworth) Centre for Inflammatory Diseases, Monash University, Department of Medicine, Clayton, Vic., Australia (Holdsworth) Department of Medicine, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia | en |
dc.description.address | S.R. Holdsworth, Department of Medicine, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia. E-mail: stephen.holdsworth@med.monash.edu.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2012 Elsevier B.V., All rights reserved. | en |
dc.identifier.authoremail | Holdsworth S.R.; stephen.holdsworth@med.monash.edu.au | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Immunology and Allergy | - |
crisitem.author.dept | Nephrology | - |
Appears in Collections: | Articles |
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