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dc.contributor.authorAeberli D.en
dc.contributor.authorLeech M.en
dc.contributor.authorMorand E.F.en
dc.date.accessioned2021-05-14T10:50:26Zen
dc.date.available2021-05-14T10:50:26Zen
dc.date.copyright2006en
dc.date.created20060912en
dc.date.issued2012-10-17en
dc.identifier.citationRheumatology. 45 (8) (pp 937-943), 2006. Date of Publication: August 2006.en
dc.identifier.issn1462-0324en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/32023en
dc.description.abstractGlucocorticoids (GCs) are widely used in the treatment of inflammatory diseases including rheumatoid arthritis (RA). Treatment with GC is associated with significant dose-dependent side-effects. The pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) has emerged in recent years as a candidate factor which could regulate GC sensitivity. MIF is induced by GC, and is able to override anti-inflammatory actions of GCs. In this review, we summarize the pro-inflammatory actions of MIF with respect to RA, describe the interactions between MIF and GC and examine new evidence, which identifies MIF as a specific target for steroid sparing. © 2006 Oxford University Press.en
dc.languageenen
dc.languageEnglishen
dc.publisherOxford University Press (Great Clarendon Street, Oxford OX2 6DP, United Kingdom)en
dc.titleMacrophage migration inhibitory factor and glucocorticoid sensitivity.en
dc.typeReviewen
dc.type.studyortrialReview article (e.g. literature review, narrative review)-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1093/rheumatology/kel142en
dc.publisher.placeUnited Kingdomen
dc.identifier.pubmedid16705047 [http://www.ncbi.nlm.nih.gov/pubmed/?term=16705047]en
dc.identifier.source44283046en
dc.identifier.institution(Aeberli, Leech, Morand) Centre for Inflammatory Diseases, Monash Institute for Medical Research, Monash Medical Centre, Locked Bag No 29, Clayton, VIC 3168, Australiaen
dc.description.addressE. Morand, Centre for Inflammatory Diseases, Monash Institute for Medical Research, Monash Medical Centre, Locked Bag No 29, Clayton, VIC 3168, Australia. E-mail: eric.morand@med.monash.edu.auen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2012 Elsevier B.V., All rights reserved.en
dc.subect.keywordsGlucocorticoids MIF Rheumatoid arthritis Steroid sparingen
dc.identifier.authoremailMorand E.F.; eric.morand@med.monash.edu.auen
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeReview-
crisitem.author.deptRheumatology-
crisitem.author.deptRheumatology-
crisitem.author.deptCentre for Inflammatory Diseases at Monash Health-
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