Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/32066
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chadban S.J. | en |
dc.contributor.author | Nguyen D. | en |
dc.contributor.author | Ping F. | en |
dc.contributor.author | Mu W. | en |
dc.contributor.author | Hill P. | en |
dc.contributor.author | Atkins R.C. | en |
dc.date.accessioned | 2021-05-14T10:51:20Z | en |
dc.date.available | 2021-05-14T10:51:20Z | en |
dc.date.copyright | 2006 | en |
dc.date.created | 20060616 | en |
dc.date.issued | 2012-10-17 | en |
dc.identifier.citation | Nephrology. 11 (3) (pp 226-231), 2006. Date of Publication: June 2006. | en |
dc.identifier.issn | 1320-5358 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/32066 | en |
dc.description.abstract | Background: Diabetic nephropathy is a major global health problem. Progression to renal failure is common; however, the mechanisms are unknown. Experimental models suggest a role for macrophages. Therefore, macrophage accumulation and its relationship to the subsequent clinical course were studied. Method(s): A retrospective study of baseline histology and the subsequent clinical course over at least 5 years involving 20 consecutive patients with a histological and clinical diagnosis of diabetic nephropathy was performed. The relationship between macrophage accumulation in renal biopsy tissue (KP-1/anti-CD68+ cells), baseline measures of known predictors of progression (proteinuria, tubulointerstitial damage, myofibroblast accumulation) and progression over 5 years (plot of reciprocal of serum creatinine) was quantified. Result(s): Accumulation of macrophages was apparent in the glomeruli (2.8 + 0.7/gcs vs 1.0 + 0.2 for normals, P = not significant) and interstitium (296.9 + 63.3/mm2vs 19.0 + 1.3/mm2 for normals, P = 0.002) of patients with diabetic nephropathy. Glomerular macrophage number correlated with baseline serum creatinine (r = 0.548, P = 0.012) but not with progression of renal failure as glomerular macrophages were prevalent in early, but not advanced diabetic nephropathy. Interstitial macrophage accumulation correlated strongly with serum creatinine (r = 0.649, P = 0.002), proteinuria (r = 0.779, P < 0.0001), interstitial fibrosis (r = 0.774, P < 0.0001) and inversely with the slope of 1/serum creatinine (r = -0.531, P = 0.023). Conclusion(s): Macrophages accumulate within glomeruli and the interstitium in diabetic nephropathy and the intensity of the interstitial infiltrate is proportional to the rate of subsequent decline in renal function. These human data support animal studies that suggest a pathogenic role for the macrophage in diabetic nephropathy. © 2006 Asian Pacific Society of Nephrology. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Blackwell Publishing (550 Swanston Street, Carlton South VIC 3053, Australia) | en |
dc.title | Macrophage accumulation in human progressive diabetic nephropathy. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/j.1440-1797.2006.00576.x | en |
dc.publisher.place | Australia | en |
dc.identifier.pubmedid | 16756636 [http://www.ncbi.nlm.nih.gov/pubmed/?term=16756636] | en |
dc.identifier.source | 43829442 | en |
dc.identifier.institution | (Nguyen, Ping, Mu, Atkins, Chadban) Department of Nephrology, Monash Medical Centre, Clayton, Vic., Australia (Hill) Department of Anatomical Pathology, St. Vincent's Hospital, Fitzroy, Vic., Australia (Nguyen) Department of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam (Ping) Department of Nephrology, First University Hospital of WCUMS, Chengdu, Sichuan, China (Chadban) Transplantation, Royal Prince Alfred Hospital, Camperdown, NSW, Australia (Chadban) Transplantation, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia | en |
dc.description.address | S.J. Chadban, Transplantation, Royal Prince Alfred Hospital, Camperdown, NSW, Australia. E-mail: steve.chadban@cs.nsw.gov.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2012 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Diabetic nephropathy Human Macrophage Progression Proteinuria | en |
dc.identifier.authoremail | Chadban S.J.; steve.chadban@cs.nsw.gov.au | en |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | Articles |
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.