Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/32258
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dc.contributor.authorNixon G.M.en
dc.contributor.authorGrimwood K.en
dc.contributor.authorJamsen K.M.en
dc.contributor.authorCarzino R.en
dc.contributor.authorRobertson C.F.en
dc.contributor.authorCarlin J.B.en
dc.contributor.authorArmstrong D.S.en
dc.contributor.authorHook S.M.en
dc.date.accessioned2021-05-14T10:55:32Zen
dc.date.available2021-05-14T10:55:32Zen
dc.date.copyright2005en
dc.date.created20051230en
dc.date.issued2012-10-18en
dc.identifier.citationPediatric Pulmonology. 40 (6) (pp 500-510), 2005. Date of Publication: December 2005.en
dc.identifier.issn8755-6863en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/32258en
dc.description.abstractControversy exists over whether the lower airway inflammation that characterizes cystic fibrosis (CF) is initiated primarily by the genetic defect. To determine if inflammation precedes infection, we examined bronchoalveolar lavage (BAL) fluid cytology, cytokines (interleukin (IL)-1beta, IL-4, IL-5, IL-6, IL-8, IL-10, and tumor necrosis factor-alpha), and free neutrophil elastase activity from 70 CF (aged 1.5-71 months) children detected by newborn screening and 19 (aged 2.0-48 months) controls with chronic stridor. CF subjects were selected and categorized as pristine (13 aged <=6 months, lacking prior respiratory symptoms and exposure to antibiotics, and without respiratory pathogens on BAL), infected (42 with viruses or >=105 colony-forming units/ml of pathogenic bacteria in BAL), and uninfected (15 aged >=6 months, asymptomatic, not taking antibiotics at bronchoscopy, and free of pathogens in their BAL). To further resolve if inflammation develops without infection, inflammatory mediators in paired annual BAL samples from 38 CF subjects were measured, and results were grouped according to whether BAL showed persistence (n = 6), acquisition (n = 8), clearance (n = 13), or absence (n = 11) of infection. While pristine, uninfected, and control subjects had similar BAL profiles, infected patients showed elevated inflammatory indices, including increased IL-10 (P < 0.001). Pristine subjects had the fewest signs of inflammation. Analysis of BAL pairs found differences between the four infection groups for changes in neutrophil percentages, IL-8 (P < 0.001), and free neutrophil elastase (P = 0.009). Infection was associated with elevated inflammatory mediators in BAL fluid. In contrast, minimal or reduced signs of inflammation accompanied absence of eradication of infection from BAL fluid. We conclude that in CF, infection initiates and sustains airway inflammation. © 2005 Wiley-Liss, Inc.en
dc.languageEnglishen
dc.languageenen
dc.publisherWiley-Liss Inc. (111 River Street, Hoboken NJ 07030-5774, United States)en
dc.titleLower airway inflammation in infants with cystic fibrosis detected by newborn screening.en
dc.typeArticleen
dc.identifier.affiliationPaediatric - Respiratory and Sleep (Melbourne Children's Sleep Centre)-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1002/ppul.20294en
dc.publisher.placeUnited Statesen
dc.identifier.pubmedid16208679 [http://www.ncbi.nlm.nih.gov/pubmed/?term=16208679]en
dc.identifier.source41720706en
dc.identifier.institution(Armstrong) Department of Paediatrics, Monash Medical Centre, Monash University, Clayton, Vic., Australia (Hook) Malaghan Institute of Medical Research, Wellington, New Zealand (Jamsen, Carlin) Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Parkville, Vic., Australia (Nixon, Carzino, Robertson) Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Vic., Australia (Grimwood) Department of Paediatrics and Child Health, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand (Grimwood) Department of Paediatrics and Child Health, Wellington School of Medicine and Health Sciences, PO Box 7343, Wellington, New Zealanden
dc.description.addressK. Grimwood, Department of Paediatrics and Child Health, Wellington School of Medicine and Health Sciences, PO Box 7343, Wellington, New Zealand. E-mail: grimwood@wnmeds.ac.nzen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2012 Elsevier B.V., All rights reserved.en
dc.subect.keywordsBronchoalveolar lavage Child Cystic fibrosis Cytokines IL-1beta IL-10 IL-6 IL-8 Infection Inflammation TNF-alphaen
dc.identifier.authoremailGrimwood K.; grimwood@wnmeds.ac.nzen
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
crisitem.author.deptPaediatric - Respiratory and Sleep (Melbourne Children's Sleep Centre)-
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