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DC Field | Value | Language |
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dc.contributor.author | Dragicevic G. | en |
dc.contributor.author | Best J.D. | en |
dc.contributor.author | Jenkins A. | en |
dc.contributor.author | Balazs N. | en |
dc.contributor.author | Rowley K.G. | en |
dc.contributor.author | O'Neal D.N. | en |
dc.contributor.author | Ansari M.Z. | en |
dc.date.accessioned | 2021-05-14T11:07:30Z | en |
dc.date.available | 2021-05-14T11:07:30Z | en |
dc.date.copyright | 2003 | en |
dc.date.created | 20030819 | en |
dc.date.issued | 2012-10-20 | en |
dc.identifier.citation | Diabetes Care. 26 (1) (pp 199-205), 2003. Date of Publication: 01 Jan 2003. | en |
dc.identifier.issn | 0149-5992 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/32813 | en |
dc.description.abstract | OBJECTIVE - To compare intimal-medial thickness (IMT) and pulse wave conduction velocity (PWCV) in unstenosed arteries of the lower limb in subjects with and without type 2 diabetes and to determine the contribution of a range of cardiovascular risk factors. RESEARCH DESIGN AND METHODS - IMT and PWCV were determined in lower-limb arteries of 79 subjects with diabetes and 77 euglycemic subjects. Plasma lipids were determined by enzymatic assays, and LDL particle size was measured by gradient gel electrophoresis. Lag time for copper-induced oxidation of LDL was determined. alpha-Tocopherol, retinol, and ascorbate levels were determined by high-performance liquid chromatography, soluble E-selectin by enzyme-linked immunosorbent assay, and fibrinogen and factor VII by automated assays. RESULTS - Subjects with diabetes had greater superficial femoral artery (SFA) IMT, popliteal artery (PA) IMT, and SFA PWCV (all P < 0.0001). In univariate analysis, IMT and PWCV correlated with increased waist-to-hip ratio, triglycerides, and fibrinogen and inversely with HDL cholesterol and LDL size. Ascorbate was inversely associated with IMT, and LDL lag time was inversely correlated with PWCV. Subjects with the greatest number of features of the metabolic syndrome had the highest IMT and PWCV. CONCLUSIONS - Adverse changes in the structure and function of unstenosed lower-limb arteries are present in type 2 diabetes and are associated with features of the metabolic syndrome. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | American Diabetes Association Inc. (1701 North Beauregard St., Alexandria VA 22311, United States) | en |
dc.title | A cross-sectional study of the effects of type 2 diabetes and other cardiovascular risk factors on structure and function of nonstenotic arteries of the lower limb. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.2337/diacare.26.1.199 | en |
dc.publisher.place | United States | en |
dc.identifier.pubmedid | 12502681 [http://www.ncbi.nlm.nih.gov/pubmed/?term=12502681] | en |
dc.identifier.source | 36929017 | en |
dc.identifier.institution | (O'Neal, Dragicevic, Rowley, Ansari, Jenkins, Best) University of Melbourne, Department of Medicine, St. Vincent's Hospital Melbourne, Fitzroy, Vic., Australia (Balazs) Monash Medical Centre, Department of Clinical Biochemistry, Clayton, Vic., Australia (Best) Department of Medicine, St.Vincent's Hospital Melbourne, Fitzroy, Vic. 3065, Australia | en |
dc.description.address | J.D. Best, Department of Medicine, St.Vincent's Hospital Melbourne, Fitzroy, Vic. 3065, Australia. E-mail: jdbest@unimelb.edu.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2012 Elsevier B.V., All rights reserved. | en |
dc.identifier.authoremail | Best J.D.; jdbest@unimelb.edu.au | en |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | Articles |
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