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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Campbell L.J. | en |
dc.contributor.author | Catalano J.V. | en |
dc.contributor.author | Arkell K. | en |
dc.contributor.author | Rayeroux K.C. | en |
dc.contributor.author | Cole-Sinclair M.F. | en |
dc.date.accessioned | 2021-05-14T11:12:11Z | en |
dc.date.available | 2021-05-14T11:12:11Z | en |
dc.date.copyright | 2002 | en |
dc.date.created | 20020730 | en |
dc.date.issued | 2012-10-18 | en |
dc.identifier.citation | British Journal of Haematology. 118 (1) (pp 243-245), 2002. Date of Publication: 2002. | en |
dc.identifier.issn | 0007-1048 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/33043 | en |
dc.description.abstract | Two acute promyelocytic leukaemia patients, treated with all-trans retinoic acid and combination chemotherapy, acquired a deletion of 11q within 12 months of diagnosis. One patient died in relapse, with both t(15;17) and del(11q) cell lines co-existing. Patient 2 remains in remission with del(11q) in 70% metaphases, despite normal marrow morphology. No deletion of the MLL gene was identified in the latter patient. The early appearance of a del(11q) is unusual, particularly without morphological evidence of myelodysplasia. We hypothesize that the del(11q) was therapy-induced but the absence of other genetic lesions has resulted in no accompanying morphological changes. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Blackwell Publishing Ltd (9600 Garsington Road, Oxford OX4 2XG, United Kingdom) | en |
dc.title | Appearance of del(11q) in two patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and combination chemotherapy. | en |
dc.type | Article | en |
dc.type.studyortrial | Case series or case report | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1046/j.1365-2141.2002.03553.x | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 12100154 [http://www.ncbi.nlm.nih.gov/pubmed/?term=12100154] | en |
dc.identifier.source | 34779543 | en |
dc.identifier.institution | (Campbell, Rayeroux, Arkell) Victorian Cancer Cytogenetics Service, St. Vincent's Hospital, Melbourne, Vic., Australia (Catalano) Department of Haematology, Monash Medical Centre, Melbourne, Vic., Australia (Cole-Sinclair) Department of Haematology, Alfred Hospital, Melbourne, Vic., Australia (Campbell) Victorian Cancer Cytogenetics Service, St. Vincent's Hospital Melbourne, PO Box 2900, Fitzroy, Vic. 3065, Australia | en |
dc.description.address | L.J. Campbell, Victorian Can. Cytogenetics Service, St. Vincent's Hospital Melbourne, PO Box 2900, Fitzroy, Vic. 3065, Australia. E-mail: campbelj@svhm.org.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2012 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | 11q deletion Acute promyelocytic leukaemia ATRA FISH Therapy-related | en |
dc.identifier.authoremail | Campbell L.J.; campbelj@svhm.org.au | en |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
Appears in Collections: | Articles |
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