Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/33488
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTesch G.H.en
dc.contributor.authorNikolic-Paterson D.J.en
dc.contributor.authorLan H.Y.en
dc.date.accessioned2021-05-14T11:21:02Zen
dc.date.available2021-05-14T11:21:02Zen
dc.date.copyright1997en
dc.date.created19980404en
dc.date.issued1998-04-04en
dc.identifier.citationNephrology. 3 (4) (pp 501-507), 1997. Date of Publication: 1997.en
dc.identifier.issn1320-5358en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/33488en
dc.description.abstractMesangial cell proliferation is a harbinger of glomerulosclerosis, leading to end-stage renal failure. It is, therefore, important to identify the factors that promote mesangial cell proliferation in order gain a better understanding of the progression of glomerular disease. A number of human and animal studies of glomerulonephritis have shown that infiltrating macrophages are prominent within mesangial proliferative lesions, suggesting that macrophages participate directly in the mesangial proliferative response. In vitro studies support a role for macrophages in mesangial cell proliferation. Macrophage interaction with mesangial cells through the action of leuckocyte adhesion molecules facilitates mesangial cell proliferation. This may be mediated by macrophage production of a number of mesangial cell growth factors or by modulating the mesangial matrix to promote mesangial cell growth. Mesangial cells may play an active role in this process, since mesangial cell production of chemoattractant molecules may be a key event in inducing macrophage recruitment into the injured mesangium. Taken together, these data suggest that macrophages and mesangial cells work in a co- operative fashion in the development of mesangioproliferative disease.en
dc.languageEnglishen
dc.languageenen
dc.publisherBlackwell Publishingen
dc.relation.ispartofNephrologyen
dc.titleDo macrophages participate in mesangial cell proliferation?.en
dc.typeReviewen
dc.type.studyortrialReview article (e.g. literature review, narrative review)-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/j.1440-1797.1997.tb00233.xen
dc.publisher.placeAustraliaen
dc.identifier.source28109578en
dc.identifier.institution(Tesch, Nikolic-Paterson, Lan) Department of Nephrology, Monash Medical Centre, Clayton Road, Clayton, Vic., Australia (Tesch) Department of Nephrology, Monash Medical Centre, Clayton Road, Clayton, Vic. 3168, Australiaen
dc.description.addressG.H. Tesch, Department of Nephrology, Monash Medical Centre, Clayton Road, Clayton, Vic. 3168, Australiaen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2020 Elsevier B.V., All rights reserved.en
dc.subect.keywordsAdhesion molecules Chemokines Macrophage Macrophage migration inhibitory factor Mesangial cell Proliferationen
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeReview-
crisitem.author.deptNephrology-
Appears in Collections:Articles
Show simple item record

Page view(s)

24
checked on Feb 6, 2025

Google ScholarTM

Check


Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.