Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/33499
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | De Kretser D. | en |
dc.contributor.author | Metcalf D. | en |
dc.contributor.author | Cory S. | en |
dc.contributor.author | Adams J.M. | en |
dc.contributor.author | Kontgen F. | en |
dc.contributor.author | Print C.G. | en |
dc.contributor.author | Loveland K.L. | en |
dc.contributor.author | Gibson L. | en |
dc.contributor.author | Meehan T. | en |
dc.contributor.author | Stylianou A. | en |
dc.contributor.author | Wreford N. | en |
dc.date.accessioned | 2021-05-14T11:21:16Z | en |
dc.date.available | 2021-05-14T11:21:16Z | en |
dc.date.copyright | 1998 | en |
dc.date.created | 19981107 | en |
dc.date.issued | 1998-11-07 | en |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America. 95 (21) (pp 12424-12431), 1998. Date of Publication: 13 Oct 1998. | en |
dc.identifier.issn | 0027-8424 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/33499 | en |
dc.description.abstract | Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the Bcl-2 family, which is widely expressed. To explore its physiological role, we have inactivated the bcl-w gene in the mouse by homologous recombination. Mice that lack Bcl-w were viable, healthy, and normal in appearance. Most tissues exhibited typical histology, and hematopoiesis was unaffected, presumably due to redundant function with other pro-survival family members. Although female reproductive function was normal, the males were infertile. The testes developed normally, and the initials prepubertal wave of spermatogenesis was largely unaffected. The seminiferous tubules of adult males, however, were disorganized, contained numerous apoptotic cells, and produced no mature sperm. Both Sertoli cells and germ cells of all types were reduced in number, the most mature germ cells being the most severely depleted. The bcl-w(-/-) mouse provides a unique model of failed spermatogenesis in the adult that may be relevant to some cases of human male sterility. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | National Academy of Sciences | en |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | en |
dc.subject | male | en |
dc.subject | animal cell | en |
dc.subject | apoptosis | en |
dc.subject | conference paper | en |
dc.subject | gene disruption | en |
dc.subject | germ cell | en |
dc.subject | male fertility | en |
dc.subject | mouse | en |
dc.subject | multigene family | en |
dc.subject | nonhuman | en |
dc.subject | priority journal | en |
dc.subject | protein expression | en |
dc.subject | rat | en |
dc.subject | Sertoli cell | en |
dc.subject | *spermatogenesis | en |
dc.subject | testis cell | en |
dc.subject | complementary DNA | en |
dc.subject | follitropin/ec [Endogenous Compound] | en |
dc.subject | luteinizing hormone/ec [Endogenous Compound] | en |
dc.subject | *protein bcl 2 | en |
dc.subject | RNA | en |
dc.title | Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1073/pnas.95.21.12424 | en |
dc.relation.url | Click here for full text options | en |
dc.publisher.place | United States | en |
dc.identifier.pubmedid | 9770502 [http://www.ncbi.nlm.nih.gov/pubmed/?term=9770502] | en |
dc.identifier.source | 28483781 | en |
dc.identifier.institution | (Print, Gibson, Metcalf, Kontgen, Adams, Cory) Walter Eliza Hall Inst. of Med. Res., Post Office, Royal Melbourne Hospital, Vic. 3050, Australia (Loveland, Meehan, Stylianou, Wreford, De Kretser) Monash Univ. Inst. Repro. and Devmt., Monash Medical Centre, 246 Clayton Road, Vic. 3168, Australia | en |
dc.description.address | S. Cory, Walter and Eliza Hall, Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Vic. 3050, Australia. E-mail: cory@wehi.edu.au | en |
dc.subject.keyword | priority journal | en |
dc.subject.keyword | protein expression | en |
dc.subject.keyword | rat | en |
dc.subject.keyword | Sertoli cell | en |
dc.subject.keyword | *spermatogenesis | en |
dc.subject.keyword | testis cell | en |
dc.subject.keyword | apoptosis | en |
dc.subject.keyword | animal cell | en |
dc.subject.keyword | conference paper | en |
dc.subject.keyword | gene disruption | en |
dc.subject.keyword | germ cell | en |
dc.subject.keyword | male | en |
dc.subject.keyword | male fertility | en |
dc.subject.keyword | mouse | en |
dc.subject.keyword | multigene family | en |
dc.subject.keyword | nonhuman | en |
dc.relation.libraryurl | LibKey Link | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2019 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Bcl-2 family Gene disruption Germ cells Sertoli cells Testis | en |
dc.identifier.authoremail | Cory S.; cory@wehi.edu.au | en |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | Articles |
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.