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DC Field | Value | Language |
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dc.contributor.author | Kitching A.R. | en |
dc.contributor.author | Holdsworth S.R. | en |
dc.contributor.author | Tipping P.G. | en |
dc.date.accessioned | 2021-05-14T11:22:37Z | en |
dc.date.available | 2021-05-14T11:22:37Z | en |
dc.date.copyright | 1999 | en |
dc.date.created | 19990130 | en |
dc.date.issued | 2012-10-19 | en |
dc.identifier.citation | European Journal of Immunology. 29 (1) (pp 1-10), 1999. Date of Publication: 1999. | en |
dc.identifier.issn | 0014-2980 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/33571 | en |
dc.description.abstract | Glomerular crescent formation characterizes severe glomerulonephritis (GN). Evidence suggests that crescent formation results from a delayed-type hypersensitivity-like Th1 response. As IL-12 directs Th1 responses, we tested the hypothesis that IL-12 is important in crescentic GN. Neutralization of IL-12 attenuated crescent formation and cell-mediated injury in C57BL/6 mice sensitized to and challenged with sheep anti-mouse glomerular basement membrane (GBM) globulin. Recombinant IL-12 induced severe crescentic GN with enhanced Th1 responses in C57BL/6 mice in which non-crescentic GN was induced by injecting anti-GBM globulin into naive mice. BALB/c mice do not develop significant crescent formation in these models, due either to regulatory effects of IL-4, or to deficits in IL-12 production/responsiveness. Administering IL-12 to BALB/c mice with GN induced Th1 responses and crescent formation, whereas IL-4-deficient BALB/c mice did not develop cell-mediated crescentic injury when GN was induced in sensitized mice. These results establish a central role for IL-12 in severe crescentic GN. | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Wiley-VCH Verlag (P.O. Box 101161, Weinheim D-69451, Germany) | en |
dc.title | IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis. | en |
dc.type | Article | en |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1002/%28SICI%291521-4141%28199901%2929:01%3C1 | en |
dc.publisher.place | Germany | en |
dc.identifier.pubmedid | 9933080 [http://www.ncbi.nlm.nih.gov/pubmed/?term=9933080] | en |
dc.identifier.source | 29043516 | en |
dc.identifier.institution | (Kitching, Tipping, Holdsworth) Centre for Inflammatory Diseases, Monash University, Monash Medical Centre, Clayton, Vic., Australia (Kitching) Department of Medicine, Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, Vic. 3168, Australia | en |
dc.description.address | A.R. Kitching, Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia. E-mail: richard.kitching@med.monash.edu.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2012 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Glomerulonephritis IL-12 IL-4 Kidney glomerulus Th1 | en |
dc.identifier.authoremail | Kitching A.R.; richard.kitching@med.monash.edu.au | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Nephrology | - |
crisitem.author.dept | Immunology and Allergy | - |
Appears in Collections: | Articles |
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