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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/33929
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dc.contributor.authorTurnidge J.D.en
dc.contributor.authorMidolo P.D.en
dc.contributor.authorLambert J.R.en
dc.date.accessioned2021-05-14T11:29:19Zen
dc.date.available2021-05-14T11:29:19Zen
dc.date.copyright1997en
dc.date.created19970423en
dc.date.issued2012-10-22en
dc.identifier.citationJournal of Antimicrobial Chemotherapy. 39 (3) (pp 331-337), 1997. Date of Publication: 1997.en
dc.identifier.issn0305-7453en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/33929en
dc.description.abstractThe bactericidal activity of the proton pump inhibitors omeprazole and lansoprazole alone and in combination with a beta-lactam or macrolide antibiotic were investigated in vitro. Time-kill curves against Helicobacter pylori NCTC 11637 and a recent clinical isolate revealed significant concentration-dependent killing with all drugs other than amoxycillin. Combinations of proton pump inhibitor and erythromycin showed synergic activity. In contrast, proton pump inhibitor plus amoxycillin showed additive activity against the clinical isolate only. Bactericidal investigations of anti-helicobacter drugs in vitro may suggest optimum treatment strategies for this common infectious disease.en
dc.languageEnglishen
dc.languageenen
dc.publisherOxford University Press (Great Clarendon Street, Oxford OX2 6DP, United Kingdom)en
dc.titleBactericidal activity and synergy studies of proton pump inhibitors and antibiotics against Helicobacter pylori in vitro.en
dc.typeArticleen
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1093/jac/39.3.331en
dc.publisher.placeUnited Kingdomen
dc.identifier.pubmedid9096182 [http://www.ncbi.nlm.nih.gov/pubmed/?term=9096182]en
dc.identifier.source27153793en
dc.identifier.institution(Midolo, Turnidge) Department of Microbiology, Monash Medical Centre, Melbourne, Vic., Australia (Lambert) Gastroenterology Research Group, Mornimton Peninsula Hospital, Melbourne, Vic., Australia (Midolo) Department of Microbiology, Monash Medical Centre, 246 Clayton Rd, Clayton, Vic. 3168, Australiaen
dc.description.addressP.D. Midolo, Dept. Microbiol. Infectious Diseases, Monash Medical Centre, 246 Clayton Rd., Clayton 3168, Vic, Australiaen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2012 Elsevier B.V., All rights reserved.en
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeArticle-
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