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Title: | Effects of chemotherapy-induced testicular damage on inhibin, gonadotropin, and testosterone secretion: A prospective longitudinal study. | Authors: | Parker A.C.;Wallace E.M. ;Wu F.C.W.;Groome N.P.;Riley S.C. | Monash Health Department(s): | Obstetrics and Gynaecology (Monash Women's) | Institution: | (Wallace) Dept. of Obstetrics and Gynaecology, Monash University, Clayton, Vic. 3168, Australia (Groome) Sch. of Biol. and Molecular Sciences, Oxford Brookes University, Oxford, United Kingdom (Riley) Dept. of Obstetrics and Gynaecology, University of Edinburgh, Edinburgh EH3 9EW, United Kingdom (Parker) Department of Haematology, University of Edinburgh, Western General Hospital, Manchester, United Kingdom (Wu) Department of Medicine, University of Manchester, Manchester Royal Infirmary, Manchester, United Kingdom (Wu) Department of Reproductive Medicine, St. Mary's Hospital, Manchester, United Kingdom (Wallace) Dept. of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia | Issue Date: | 22-Oct-2012 | Copyright year: | 1997 | Publisher: | Endocrine Society (8401 Connecticut Ave. Suite 900, Chevy Chase MD 20815, United States) | Place of publication: | United States | Publication information: | Journal of Clinical Endocrinology and Metabolism. 82 (9) (pp 3111-3115), 1997. Date of Publication: 1997. | Abstract: | To investigate the role of inhibin in the control of follicle- stimulating hormone (FSH) secretion, we have measured levels of immunereactive inhibin (ir-inhibin), inhibin B, Pro-alphaC containing inhibins, FSH, luteinizing hormone (LH), and testosterone in twelve men with hematological malignancies before, during, and after chemotherapy. Inhibin B levels fell significantly by i month from a mean +/- SE baseline level of 273.2 +/- 32.8 pg/mL, reaching a nadir of 52.6 +/- 15.3 pg/mL at 4 months (P < 0.0001). FSH levels increased within the first month from a baseline level of 3.9 +/- 0.6 IU/L, reaching a peak level of 22.4 +/- 3.3 IU/L at 4 months (P < 0.0001). FSH and inhibin B were significantly and inversely correlated (r = 0.69, P < 0.0001). Pro-alphaC containing inhibin levels increased significantly (P < 0.05) at 8 months and were significantly and positively correlated with FSH (r = 0.88, P = 0.002). LH levels increased significantly but to a much lesser extent than FSH, the increase becoming evident only 4 months after treatment commenced (P < 0.03). Levels of ir-inhibin and testosterone remained unchanged throughout the study. These data provide strong support to the hypothesis that inhibin B is the physiologically important form of inhibin in men, negatively regulating FSH secretion at the pituitary. Furthermore, they suggest that FSH stimulates inhibin alpha-subunit secretion by the testis. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1210/jcem.82.9.4238 | PubMed URL: | 9284754 [http://www.ncbi.nlm.nih.gov/pubmed/?term=9284754] | ISSN: | 0021-972X | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/33961 | Type: | Article |
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