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DC Field | Value | Language |
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dc.contributor.author | Berger P.J. | en |
dc.contributor.author | Adamson T.M. | en |
dc.contributor.author | Blanch N. | en |
dc.contributor.author | Wilkinson M.H. | en |
dc.contributor.author | Cranage S. | en |
dc.date.accessioned | 2021-05-14T11:33:42Z | en |
dc.date.available | 2021-05-14T11:33:42Z | en |
dc.date.copyright | 1995 | en |
dc.date.created | 19951009 | en |
dc.date.issued | 2012-10-25 | en |
dc.identifier.citation | Pediatric Research. 38 (4) (pp 533-538), 1995. Date of Publication: 1995. | en |
dc.identifier.issn | 0031-3998 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/34170 | en |
dc.description.abstract | The progressive decrease in the periodic cycle duration (PCD) of periodic breathing with postnatal age in term infants has been previously reported by a number of authors and is thought to be associated with peripheral chemoreceptor maturation. We hypothesized that a similar decrease should be observed in preterm infants. Therefore, in this study we measured the changes in PCD with postnatal age in a small group of preterm (n = 4) infants followed longitudinally (36 afternoon nap studies) over the first 6 mo postnatally. PCD declined in these infants from 17.1 +/- 3.3 s (mean +/- 2 SD) at 9 d to 9.8 +/- 3.2 s (mean +/- 2 SD) at 105 d. The regression slope was - 0.072 s/d. Beyond 105 d there was no change in PCD up to 6 mo postnatally. We found no significant difference between active and quiet sleep. These results are similar to results previously published in term infants but apparently contradict recent data on a group of preterm infants. Possible reasons for this discrepancy are discussed. By examining long epochs of periodic breathing in these infants we also identified characteristic changes in PCD and V/A ratio, defined as the duration of the ventilatory period divided by the duration of the apneic interval, V/A ratio fell from the start of an epoch from 1.21 +/- 0.08 (mean +/- SEM) to a minimum of 0.62 +/- 0.03 and then increased again to 0.8 +/- 0.05 at the end of the epoch. We conclude that important maturational changes occur in the neonatal respiratory control system during the first 6 mo postnatally and that these changes are reflected in a fall in PCD of periodic breathing over this period. We also conclude that the characteristic changes which occur in V/A ratio and PCD are consistent with a role for chemical stimuli in the genesis of periodic breathing. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Lippincott Williams and Wilkins (351 West Camden Street, Baltimore MD 21201-2436, United States) | en |
dc.title | Changes in the temporal structure of periodic breathing with postnatal development in preterm infants. | en |
dc.type | Article | en |
dc.publisher.place | United States | en |
dc.identifier.pubmedid | 8559605 [http://www.ncbi.nlm.nih.gov/pubmed/?term=8559605] | en |
dc.identifier.source | 25285064 | en |
dc.identifier.institution | (Wilkinson, Cranage, Berger, Blanch, Adamson) Inst. of Reproduction/Development, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia | en |
dc.description.address | M.H. Wilkinson, Inst. of Reproduction/Development, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2012 Elsevier B.V., All rights reserved. | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
Appears in Collections: | Articles |
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