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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/34875
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dc.contributor.authorLevinger I.en
dc.contributor.authorByrnes E.en
dc.contributor.authorFlicker L.en
dc.contributor.authorDuque G.en
dc.contributor.authorYeap B.B.en
dc.contributor.authorScott D.en
dc.contributor.authorSmith C.en
dc.contributor.authorVoisin S.en
dc.contributor.authorAl Saedi A.en
dc.contributor.authorPhu S.en
dc.contributor.authorBrennan-Speranza T.en
dc.contributor.authorParker L.en
dc.contributor.authorEynon N.en
dc.contributor.authorHiam D.en
dc.contributor.authorYan X.en
dc.contributor.authorBlekkenhorst L.C.en
dc.contributor.authorLewis J.R.en
dc.contributor.authorSeeman E.en
dc.date.accessioned2021-05-14T11:46:26Zen
dc.date.available2021-05-14T11:46:26Zen
dc.date.copyright2020en
dc.date.created20191111en
dc.date.issued2019-11-11en
dc.identifier.citationBone. 130 (no pagination), 2020. Article Number: 115085. Date of Publication: January 2020.en
dc.identifier.issn8756-3282en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/34875en
dc.description.abstractPurpose: Osteocalcin (OC), an osteoblast-specific secreted protein expressed by mature osteoblasts, is used in clinical practice and in research as a marker of bone turnover. The carboxylated (cOC) and undercarboxylated (ucOC) forms may have a different biological function but age-specific reference ranges for these components are not established. Given the different physiological roles, development of reference ranges may help to identify people at risk for bone disease. Method(s): Blood was collected in the morning after an overnight fast from 236 adult men (18 to 92 years old) free of diabetes, antiresorptive, warfarin or glucocorticoid use. Serum was analyzed for total osteocalcin (tOC) and the ucOC fraction using the hydroxyapatite binding method. cOC, ucOC/tOC and cOC/tOC ratios were calculated. Reference intervals were established by polynomial quantile regression analysis. Result(s): The normal ranges for young men (<=30 years) were: tOC 17.9-56.8 ng/mL, ucOC 7.1-22.0 ng/mL, cOC 8.51-40.3 ng/mL (2.5th to 97.5th quantiles). Aging was associated with a "U" shaped pattern for tOC, cOC and ucOC levels. ucOC/tOC ratio was higher, while cOC/tOC ratio was lower in men of advanced age. Age explained ~31%, while body mass index explained ~4%, of the variance in the ratios. Conclusion(s): We have defined normal reference ranges for the OC forms in Australian men and demonstrated that the OC ratios may be better measures, than the absolute values, to identify the age-related changes on OC in men. These ratios may be incorporated into future research and clinical trials, and their associations with prediction of events, such as fracture or diabetes risk, should be determined.Copyright © 2019 Elsevier Inc.en
dc.languageEnglishen
dc.languageenen
dc.publisherElsevier Inc. (E-mail: usjcs@elsevier.com)en
dc.relation.ispartofBoneen
dc.titleOsteocalcin and its forms across the lifespan in adult men.en
dc.typeArticleen
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.bone.2019.115085en
dc.publisher.placeUnited Statesen
dc.identifier.pubmedid31622778 [http://www.ncbi.nlm.nih.gov/pubmed/?term=31622778]en
dc.identifier.source2003678312en
dc.identifier.institution(Smith, Voisin, Eynon, Hiam, Yan, Levinger) Institute for Health and Sport (iHeS), Victoria University, Melbourne, VIC, Australia (Smith, Al Saedi, Phu, Scott, Duque, Levinger) Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, VIC, Australia (Al Saedi, Phu, Duque, Levinger) Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia (Brennan-Speranza) Department of Physiology and Bosch Institute for Medical Research, University of Sydney, New South Wales, Australia (Parker) Institute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, VIC, Australia (Eynon) Murdoch Childrens Research Institute, Melbourne, Australia (Scott) School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia (Blekkenhorst, Lewis) School of Medical and Health Sciences, Edith Cowan University, Perth, Australia (Blekkenhorst, Lewis, Flicker, Yeap) Medical School, University of Western Australia, Perth, Australia (Lewis) Centre for Kidney Research, Children's Hospital at Westmead School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australia (Seeman) University of Melbourne and the Department of Endocrinology, Austin Health and the Mary Mackillop Institute of Healthy Aging, Australian Catholic University, Melbourne, Australia (Byrnes) Department of Biochemistry, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth, Australia (Flicker) Western Australian Centre for Health & Ageing, University of Western Australia, Perth, Australia (Yeap) Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Australiaen
dc.description.addressI. Levinger, Institute for Health and Sport (iHeS), Victoria University, PO Box 14428, Melbourne, Australia. E-mail: itamar.levinger@vu.edu.auen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2019 Elsevier B.V., All rights reserved.en
dc.subect.keywordsAging Bone Bone turnover Osteocalcin Reference rangesen
dc.identifier.authoremailLevinger I.; itamar.levinger@vu.edu.auen
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
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