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Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Doan J. | en |
dc.contributor.author | Malhotra A. | en |
dc.contributor.author | Krishnamurthy M.B. | en |
dc.contributor.author | Kottayam R. | en |
dc.date.accessioned | 2021-05-14T11:56:40Z | en |
dc.date.available | 2021-05-14T11:56:40Z | en |
dc.date.copyright | 2020 | en |
dc.date.created | 20200617 | en |
dc.date.issued | 2020-06-17 | en |
dc.identifier.citation | Journal of Paediatrics and Child Health. 56 (5) (pp 757-763), 2020. Date of Publication: 01 May 2020. | en |
dc.identifier.issn | 1034-4810 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/35361 | en |
dc.description.abstract | Aim: To describe the presenting features and investigation findings in infants diagnosed with neonatal alloimmune neutropaenia (NAIN) within an Australian paediatric health network. The secondary aim was to describe the management and resolution of neutropaenia in infants with NAIN. Method(s): A retrospective cohort study was conducted at Monash Children's Hospital, Melbourne, Australia. Infants referred to the Victorian Transplantation and Immunogenetics Service for evaluation of NAIN were identified and medical records were reviewed. Descriptive statistical analysis of infants' clinical outcomes, investigation findings and management was performed. Result(s): Nine infants were diagnosed with NAIN between December 2004 and June 2017. Overall incidence of NAIN was around 1 per 10 000 births. Median gestational age was 38 (range 35-40) weeks and birthweight was 2920 (2300-4445) g. Median age at NAIN work-up was 7 (2-33) days. Prior to investigation for NAIN, median absolute neutrophil count was 0.2 (0.01-0.6) x 109 cells/L. The post-natal ward was the source of presentation in most infants (78%). All except one infant were admitted to a neonatal unit and commenced on intravenous antibiotics (89%). Six infants were asymptomatic but received antibiotics for risk of infection (75%). Granulocyte-colony stimulating factor was administered to 44% of infants due to neutropaenia with presumed or confirmed infection. NAIN resolved at median age of 32 (6-200) days. Conclusion(s): Infants with NAIN frequently presented with severe, unexpected neutropaenia without major infection. Intravenous antibiotic therapy and granulocyte-colony stimulating factor use was common in this cohort.Copyright © 2019 Paediatrics and Child Health Division (The Royal Australasian College of Physicians) | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Blackwell Publishing | en |
dc.relation.ispartof | Journal of Paediatrics and Child Health | en |
dc.subject.mesh | neutrophil count | - |
dc.subject.mesh | newborn | - |
dc.subject.mesh | newborn disease | - |
dc.subject.mesh | cefotaxime | - |
dc.subject.mesh | flucloxacillin | - |
dc.subject.mesh | gentamicin | - |
dc.subject.mesh | granulocyte antibody | - |
dc.subject.mesh | granulocyte colony stimulating factor | - |
dc.subject.mesh | penicillin G | - |
dc.subject.mesh | neonatal alloimmune neutropenia | - |
dc.subject.mesh | omphalitis/co | - |
dc.subject.mesh | incidental finding | - |
dc.subject.mesh | infection/co | - |
dc.subject.mesh | infection | - |
dc.subject.mesh | neutropenia/co | - |
dc.subject.mesh | antibiotic therapy | - |
dc.subject.mesh | asymptomatic disease | - |
dc.subject.mesh | Australian | - |
dc.subject.mesh | birth weight | - |
dc.subject.mesh | gestational age | - |
dc.subject.mesh | neutropenia | - |
dc.title | Neonatal alloimmune neutropaenia: Experience from an Australian paediatric health service. | en |
dc.type | Article | en |
dc.identifier.affiliation | Paediatric - Neonatal (Monash Newborn) | - |
dc.identifier.affiliation | Paediatric - Haematology-Oncology (Children's Cancer Centre) | - |
dc.type.studyortrial | Observational study (cohort, case-control, cross sectional or survey) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/jpc.14735 | - |
dc.publisher.place | Australia | en |
dc.identifier.pubmedid | 31858675 [http://www.ncbi.nlm.nih.gov/pubmed/?term=31858675] | en |
dc.identifier.source | 2003911177 | en |
dc.identifier.institution | (Doan, Krishnamurthy, Malhotra) Monash Newborn, Monash Children's Hospital, Melbourne, VIC, Australia (Kottayam) Children's Cancer Centre, Monash Children's Hospital, Melbourne, VIC, Australia (Malhotra) Department of Paediatrics, Monash University, Melbourne, VIC, Australia | en |
dc.description.address | A. Malhotra, Monash Newborn, Monash Children's Hospital, Melbourne, VIC, Australia. E-mail: atul.malhotra@monash.edu | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2020 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | antibiotics granulocyte-colony stimulating factor infection neutropenia newborn | en |
dc.identifier.authoremail | Malhotra A.; atul.malhotra@monash.edu | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Paediatric - Neonatal (Monash Newborn) | - |
Appears in Collections: | Articles |
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