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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | MacDonald P. | en |
dc.contributor.author | Testro A. | en |
dc.contributor.author | Pavlovic J. | en |
dc.contributor.author | Sullivan L.C. | en |
dc.contributor.author | Westall G.P. | en |
dc.contributor.author | Snell G.I. | en |
dc.contributor.author | Kummrow M. | en |
dc.contributor.author | Hiho S. | en |
dc.contributor.author | Hudson F. | en |
dc.contributor.author | Cantwell L. | en |
dc.contributor.author | Mulley W.R. | en |
dc.contributor.author | D'Orsogna L. | en |
dc.date.accessioned | 2021-05-14T12:03:47Z | en |
dc.date.available | 2021-05-14T12:03:47Z | en |
dc.date.copyright | 2019 | en |
dc.date.created | 20190507 | en |
dc.date.issued | 2019-05-07 | en |
dc.identifier.citation | American Journal of Transplantation. 19 (5) (pp 1577-1581), 2019. Date of Publication: May 2019. | en |
dc.identifier.issn | 1600-6135 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/35667 | en |
dc.description.abstract | Antibody-mediated rejection, whereby transplant recipient B cells and/or plasma cells produce alloreactive anti-human leukocyte antigen (HLA) antibodies, negatively influences transplant outcomes and is a major contributor to graft loss. An early humoral immune response is suggested by the production of anti-HLA donor-specific antibodies (DSA) that can be measured using solid phase assays. We report the early posttransplant coexistence of a shared anti-HLA antibody profile in 5 solid organ transplant recipients who received organs from the same donor. Retrospective analysis of the donor's serum confirmed the presence of the same anti-HLA profile, suggesting the transfer of donor-derived anti-HLA antibodies, or the cells that produce them, to multiple solid organ transplant recipients. The time frame and extent of transfer suggest a novel variant of the passenger lymphocyte syndrome. These findings have important implications for the consideration of all posttransplant antibody measurements, particularly the interpretation of non-DSAs in the sera of transplant recipients.Copyright © 2019 The American Society of Transplantation and the American Society of Transplant Surgeons | en |
dc.language | en | en |
dc.language | English | en |
dc.publisher | Blackwell Publishing Ltd | en |
dc.relation.ispartof | American Journal of Transplantation | en |
dc.title | Transfer of donor anti-HLA antibody expression to multiple transplant recipients: A potential variant of the passenger lymphocyte syndrome?. | en |
dc.type | Article | en |
dc.type.studyortrial | Case series or case report | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/ajt.15262 | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 30653828 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30653828] | en |
dc.identifier.source | 626361881 | en |
dc.identifier.institution | (Kummrow, Hiho, Hudson, Cantwell) Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, Melbourne, VIC, Australia (Hiho, Sullivan, Snell, Westall) Lung Transplant Service, Alfred Hospital, Melbourne, VIC, Australia (Mulley) Department of Nephrology, Monash Medical Centre, Clayton, VIC, Australia (D'Orsogna) Department of Clinical Immunology, Fiona Stanley Hospital, Perth, WA, Australia (Testro, Pavlovic) Liver Transplant Unit, Austin Hospital, Melbourne, VIC, Australia (MacDonald) Heart Transplant Service, St Vincent's Hospital, Sydney, NSW, Australia (Sullivan) Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia | en |
dc.description.address | G.I. Snell, Lung Transplant Service, Alfred Hospital, Melbourne, VIC, Australia. E-mail: G.Snell@alfred.org.au | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2019 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | clinical research/practice crossmatch histocompatibility lung (allograft) function/dysfunction lung transplantation/pulmonology major histocompatibility complex (MHC) organ transplantation in general rejection: antibody-mediated (ABMR) | en |
dc.identifier.authoremail | Snell G.I.; G.Snell@alfred.org.au | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
Appears in Collections: | Articles |
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