Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/35828
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lan H.-Y. | en |
dc.contributor.author | Tang P.M.-K. | en |
dc.contributor.author | Nikolic-Paterson D.J. | en |
dc.date.accessioned | 2021-05-14T12:07:30Z | en |
dc.date.available | 2021-05-14T12:07:30Z | en |
dc.date.copyright | 2019 | en |
dc.date.created | 20190301 | en |
dc.date.issued | 2019-03-01 | en |
dc.identifier.citation | Nature Reviews Nephrology. 15 (3) (pp 144-158), 2019. Date of Publication: 01 Mar 2019. | en |
dc.identifier.issn | 1759-5061 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/35828 | en |
dc.description.abstract | Macrophages have important roles in immune surveillance and in the maintenance of kidney homeostasis; their response to renal injury varies enormously depending on the nature and duration of the insult. Macrophages can adopt a variety of phenotypes: at one extreme, M1 pro-inflammatory cells contribute to infection clearance but can also promote renal injury; at the other extreme, M2 anti-inflammatory cells have a reparative phenotype and can contribute to the resolution phase of the response to injury. In addition, bone marrow monocytes can differentiate into myeloid-derived suppressor cells that can regulate T cell immunity in the kidney. However, macrophages can also promote renal fibrosis, a major driver of progression to end-stage renal disease, and the CD206+ subset of M2 macrophages is strongly associated with renal fibrosis in both human and experimental diseases. Myofibroblasts are important contributors to renal fibrosis and recent studies provide evidence that macrophages recruited from the bone marrow can transition directly into myofibroblasts within the injured kidney. This process is termed macrophage-to-myofibroblast transition (MMT) and is driven by transforming growth factor-beta1 (TGFbeta1)-Smad3 signalling via a Src-centric regulatory network. MMT may serve as a key checkpoint for the progression of chronic inflammation into pathogenic fibrosis.Copyright © 2019, Springer Nature Limited. | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Nature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom) | en |
dc.relation.ispartof | Nature Reviews Nephrology | en |
dc.title | Macrophages: versatile players in renal inflammation and fibrosis. | en |
dc.type | Review | en |
dc.type.studyortrial | Review article (e.g. literature review, narrative review) | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41581-019-0110-2 | en |
dc.publisher.place | United Kingdom | en |
dc.identifier.pubmedid | 30692665 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30692665] | en |
dc.identifier.source | 626155345 | en |
dc.identifier.institution | (Tang, Lan) Department of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong (Tang) Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong (Nikolic-Paterson) Department of Nephrology, Monash Medical Centre and Monash University Centre for Inflammatory Diseases, Melbourne, VIC, Australia | en |
dc.description.address | H.-Y. Lan, Department of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong. E-mail: hylan@cuhk.edu.hk | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2019 Elsevier B.V., All rights reserved. | en |
dc.identifier.authoremail | Lan H.-Y.; hylan@cuhk.edu.hk | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Review | - |
crisitem.author.dept | Nephrology | - |
Appears in Collections: | Articles |
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.