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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/35896
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dc.contributor.authorPeters J.en
dc.contributor.authorKempster P.en
dc.contributor.authorAmukotuwa S.en
dc.contributor.authorDing C.en
dc.date.accessioned2021-05-14T12:09:08Zen
dc.date.available2021-05-14T12:09:08Zen
dc.date.copyright2019en
dc.date.created20191106en
dc.date.issued2019-11-06en
dc.identifier.citationJournal of Clinical Neuroscience. 69 (pp 279-280), 2019. Date of Publication: November 2019.en
dc.identifier.issn0967-5868en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/35896en
dc.description.abstractA 23-year old man was found to have a Chiari Type 1 malformation and cerebellar atrophy. While this association has previously been described, the remote cerebellar atrophy is difficult to explain. We believe the answer lies with our finding of signal hyperintensity on MR imaging at the level of the inferior olives. This suggest hypertrophic olivary degeneration, caused by trans-synaptic degeneration following disruption to the Guillain-Mollaret triangle. Propagation of this process to the cerebellar Purkinje cells occurs in some cases. We describe a case in support of this hypothesis and review previously published evidence.Copyright © 2019 Elsevier Ltden
dc.languageEnglishen
dc.languageenen
dc.publisherChurchill Livingstoneen
dc.relation.ispartofJournal of Clinical Neuroscienceen
dc.titleCerebellar atrophy with Chiari malformation: An example of trans-synaptic degeneration?.en
dc.typeArticleen
dc.type.studyortrialCase series or case report-
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.jocn.2019.08.005en
dc.publisher.placeUnited Kingdomen
dc.identifier.pubmedid31447362 [http://www.ncbi.nlm.nih.gov/pubmed/?term=31447362]en
dc.identifier.source2002662194en
dc.identifier.institution(Peters, Ding, Kempster) Neurosciences Department, Monash Medical Centre, Clayton, Australia (Amukotuwa) Department of Imaging, Monash Medical Centre, Clayton, Australia (Kempster) Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Australiaen
dc.description.addressJ. Peters, Monash Medical Centre Level 2, 246 Clayton Road, Clayton, Vic 3168, Australia. E-mail: James.Peters@monashhealth.orgen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2019 Elsevier B.V., All rights reserved.en
dc.subect.keywordsCerebellar atrophy Chiari malformation Hypertrophic olivary degeneration Trans-synaptic degenerationen
dc.identifier.authoremailPeters J.; James.Peters@monashhealth.orgen
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptNeurology-
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